产品简要
公司名称 :
Alomone Labs
产品类型 :
抗体
产品名称 :
抗NMDAR1(GluN1)(细胞外)抗体
目录 :
AGC-001
规格 :
25微升, 50微升, 0.2毫升
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
更多信息或购买 :
文章摘录数: 12
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 小鼠; 1:100; 图 s2
Roshanravan H, Kim E, Dryer S. NMDA Receptors as Potential Therapeutic Targets in Diabetic Nephropathy: Increased Renal NMDA Receptor Subunit Expression in Akita Mice and Reduced Nephropathy Following Sustained Treatment With Memantine or MK-801. Diabetes. 2016;65:3139-50 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100; 图 9
Leshchyns ka I, Liew H, Shepherd C, Halliday G, Stevens C, Ke Y, et al. Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease. Nat Commun. 2015;6:8836 pubmed 出版商
Makuch M, Wilson R, Al Diwani A, Varley J, Kienzler A, Taylor J, et al. N-methyl-D-aspartate receptor antibody production from germinal center reactions: Therapeutic implications. Ann Neurol. 2018;83:553-561 pubmed 出版商
Jezequel J, Johansson E, Dupuis J, Rogemond V, Gréa H, Kellermayer B, et al. Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients. Nat Commun. 2017;8:1791 pubmed 出版商
Gobbo F, Marchetti L, Jacob A, Pinto B, Binini N, Pecoraro Bisogni F, et al. Activity-dependent expression of Channelrhodopsin at neuronal synapses. Nat Commun. 2017;8:1629 pubmed 出版商
Aloisi E, Le Corf K, Dupuis J, Zhang P, Ginger M, Labrousse V, et al. Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice. Nat Commun. 2017;8:1103 pubmed 出版商
Oh J, Rhee S, Silva A, Lee Y, Kim H. Noonan syndrome-associated SHP2 mutation differentially modulates the expression of postsynaptic receptors according to developmental maturation. Neurosci Lett. 2017;649:41-47 pubmed 出版商
Lesept F, Chevilley A, Jezequel J, Ladépêche L, Macrez R, Aimable M, et al. Tissue-type plasminogen activator controls neuronal death by raising surface dynamics of extrasynaptic NMDA receptors. Cell Death Dis. 2016;7:e2466 pubmed 出版商
Telezhkin V, Schnell C, Yarova P, Yung S, Cope E, Hughes A, et al. Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons. Am J Physiol Cell Physiol. 2016;310:C520-41 pubmed 出版商
Atkin G, Moore S, Lu Y, Nelson R, Tipper N, Rajpal G, et al. Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity. J Neurosci. 2015;35:6165-78 pubmed 出版商
Dupuis J, Ladépêche L, Seth H, Bard L, VARELA J, Mikasova L, et al. Surface dynamics of GluN2B-NMDA receptors controls plasticity of maturing glutamate synapses. EMBO J. 2014;33:842-61 pubmed 出版商
Mikasova L, de Rossi P, Bouchet D, Georges F, Rogemond V, Didelot A, et al. Disrupted surface cross-talk between NMDA and Ephrin-B2 receptors in anti-NMDA encephalitis. Brain. 2012;135:1606-21 pubmed 出版商
图像
图像 1 :
Alomone Labs AGC-001 图像 1
Western blot analysisof rat brain lysate: - 1. Anti-NMDAR1 (GluN1) (extracellular) Antibody(#AGC-001) (1:600).2. Anti-NMDAR1 (GluN1) (extracellular) Antibody preincubated with the negative control antigen.
图像 2 :
Alomone Labs AGC-001 图像 2
Peptide ETEKPRGYQMSTRLK(C) corresponding to amino acid residues385-399 of rat NMDA receptor 1 (AccessionP35439). Extracellular N-terminus.
图像 3 :
Alomone Labs AGC-001 图像 3
Immuno-colocalization of GluN1 and CALHM1 in mouse hippocampal CA1 region - Immunohistochemical staining of perfusion-fixed frozen mouse brain sectionsusingAnti-NMDAR1 (GluN1) (extracellular) Antibody(#AGC-001) (1:200) and Anti-CALHM1-ATTO-594 Antibody (#ACC-101-AR) (1:60). A. Sections were stained with Anti-NMDAR1 (GluN1) (extracellular)Antibody followed by goat-anti-rabbit-Cy2 (green). Staining reveals expression in neurons of the pyramidal layer (an arrow points at the layer). B. The same section was incubated with Anti-CALHM1-ATTO-594 Antibody (red). C. Merge of the two images demonstrates colocalization of GluN1 and CALHM1 in pyramidal neurons.
产品信息
供应商 :
Alomone Labs Ltd.
产品名 :
抗NMDAR1(GluN1)(细胞外)抗体
目录号 :
AGC-001
产品类型 :
抗体
规格 :
25微升, 50微升, 0.2毫升
同源 :
Human, mouse - identical.
同义词 :
NMDAR1 (GluN1), NMDA receptor 1, Ionotropic glutamate receptor subunit zeta1, N-methyl-D-aspartate receptor subunit 1, GRIN1
交叉活性 :
人类, 小鼠, 大鼠
应用 :
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Live Cell Imaging, Western Blot
抗体类型 :
多克隆
宿主 :
共轭标签/标签/标记 :
未共轭
SwissProt号 :
P35439
浓度 :
0.8毫克/毫升
格式 :
Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
缓冲液 :
磷酸盐缓冲液(PBS), pH值7.4
防腐剂 :
1% BSA, 0.05% NaN3
包装 :
冻干粉末
储存 :
The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
纯度 :
Affinity purified on immobilized antigen.
抗体亚型 :
兔IgG
免疫原 :
合成肽
克隆性 :
多克隆
区域/地区/末端 :
细胞外, N末端
免疫原序列 :
ETEKPRGYQMSTRLK(C), corresponding to amino acid residues 385-399 of rat NMDA receptor 1
类别 :
Ion Channels, Ligand-Gated Ion Channels, Glutamate Receptors
研究领域(s) :
Pain, Nociception, Somatosensory, Touch, Neuroscience, Epilepsy, Olfactory, Smell, Olfactory System, Taste, Gustatory System, Visual, Auditory, Auditory System, Hearing, Sensory System, Cancer, tumor, tumour, Neurological Diseases, Addiction, Reward, Depression, Huntington's Disease, Neurodegeneration, Neurodegenerative Disease
更多信息或购买 :
公司信息
Alomone Labs
Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201
info@alomone.com
http://www.alomone.com
972-2-587-2202
公司总部: 以色列
Alomone Labs公司成立于1989年,在离子通道、GPCR及神经信号通路研究等领域占据全球领先地位。