小鼠抗大鼠p75神经生长因子受体(细胞外)抗体

产品简要

公司名称 :

Alomone Labs

产品类型 :

抗体

产品名称 :

小鼠抗大鼠p75神经生长因子受体(细胞外)抗体

AN-170

规格 :

1 X 10 mcg

价格 :

357美元

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

未共轭

反应物种 :

人类, 大鼠

应用 :

免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-冰冻切片

更多信息或购买 :

Alomone Labs 产品网页

文章摘录数: 10

出版应用/物种/样本/稀释	参考文献
免疫组化-冰冻切片; 大鼠; 1:2000; 图 1f	Koike T, Tanaka S, Hirahara Y, Oe S, Kurokawa K, Maeda M, et al. Morphological characteristics of p75 neurotrophin receptor-positive cells define a new type of glial cell in the rat dorsal root ganglia. J Comp Neurol. 2019;527:2047-2060 pubmed 出版商
	Salvo E, Tu N, Scheff N, Dubeykovskaya Z, Chavan S, Aouizerat B, et al. TNFα promotes oral cancer growth, pain, and Schwann cell activation. Sci Rep. 2021;11:1840 pubmed 出版商
	Olianas M, Dedoni S, Onali P. Antidepressants induce profibrotic responses via the lysophosphatidic acid receptor LPA1. Eur J Pharmacol. 2020;873:172963 pubmed 出版商
	El Habta R, Kingham P, Backman L. Adipose stem cells enhance myoblast proliferation via acetylcholine and extracellular signal-regulated kinase 1/2 signaling. Muscle Nerve. 2018;57:305-311 pubmed 出版商
	Chen W, Sheng J, Guo J, Gao F, Zhao X, Dai J, et al. Tumor necrosis factor-Î± enhances voltage-gated Naâº currents in primary culture of mouse cortical neurons. J Neuroinflammation. 2015;12:126 pubmed 出版商
	Mitrofanova L, Gorshkov A, Lebedev D, Mikhaylov E. Evidence of specialized tissue in human interatrial septum: histological, immunohistochemical and ultrastructural findings. PLoS ONE. 2014;9:e113343 pubmed 出版商
	Hsu H, Tang N, Lin Y, Li T, Liu H, Hsieh C. Effect of electroacupuncture on rats with chronic constriction injury-induced neuropathic pain. ScientificWorldJournal. 2014;2014:129875 pubmed 出版商
	Tan J, Shepherd R. Aminoglycoside-induced degeneration of adult spiral ganglion neurons involves differential modulation of tyrosine kinase B and p75 neurotrophin receptor signaling. Am J Pathol. 2006;169:528-43 pubmed
	Kuwako K, Hosokawa A, Nishimura I, Uetsuki T, Yamada M, Nada S, et al. Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survival. J Neurosci. 2005;25:7090-9 pubmed
	Tcherpakov M, Bronfman F, Conticello S, Vaskovsky A, Levy Z, Niinobe M, et al. The p75 neurotrophin receptor interacts with multiple MAGE proteins. J Biol Chem. 2002;277:49101-4 pubmed

图像

图像 1 :

Western blot analysis of PC12 cell lysate (non-reduced): - 1. Mouse Anti-Rat p75 NGF Receptor (extracellular) Antibody (#AN-170), (1:2500).2. Mouse Anti-Rat p75 NGF Receptor (extracellular) Antibody (1:1500).3. Mouse Anti-Rat p75 NGF Receptor (extracellular) Antibody (1:150).

图像 2 :

Multiplex staining of Plexin-A2 and p75NTR in rat brain - Immunohistochemical staining of perfusion-fixed frozen rat brain sections using Anti-Plexin-A2 (extracellular) Antibody (#APR-082), (1:400) and Mouse Anti-Rat p75 NGF Receptor (extracellular) Antibody (#AN-170), (1:300). A. Sections of rat horizontal diagonal band (HDB) were stained for Plexin-A2 (green). B. Same sections were stained for p75NTR (red). C. Merge of the two images reveals cells expressing both Plexin-A2 and p75NTR (horizontal arrows), cells expressing only Plexin-A2 (upwards pointing arrows) or cells expressing only p75NTR (downwards pointing arrows) can also be observed. Cell nuclei are stained with DAPI (blue).

产品信息

SKU号 :

AN-170_1_10_mcg

ParentSKU :

AN-170

Taxonomy Node :

Primary Antibody>Extracellular>Non-Labeled

Action :

Insert

产品名称 :

小鼠抗大鼠p75神经生长因子受体(细胞外)抗体

产品描述 :

Mouse Anti-Rat p75 NGF Receptor (extracellular) Antibody (#AN-170) is a highly specific monoclonal antibody directed against p75NTR. The antibody can be used in western blot, immunohistochemistry, and indirect flow cytometry applications. It has been designed to recognize p75NTR from rat samples only.

Short Description :

A小鼠单克隆抗体大鼠神经营养因子受体p75NTR

同义词 :

p75 NGF Receptor, p75NTR, NGFR, CD271, TNFR superfamily member 16

靶标名 :

大鼠神经营养因子受体p75NTR

Primary Category (Old) :

Neurotrophic Factors and Receptors > Neurotrophin Receptors and Co-Receptors > Antibodies to Receptors and Co-Receptors

标记/共轭标签 :

未共轭

应用 :

IF, IFC, 免疫组化, 免疫印迹

宿主 :

小鼠

克隆性 :

单克隆

抗体亚型 :

IgG1

基因符号 :

神经生长因子受体

反应物种 :

大鼠(试验)

靶标/背景信息 :

p75NTR known as a cell surface receptor for NGF, BDNF, NT-3 and NT-4, is also a receptor for b-amyloid, and for the myelin axon repellant protein MAG.1,2,4,6 Binding of neurotrophins induces receptor dimerization followed by phosphorylation of receptor kinase residues and recruitment of intracellular proteins involved in signal transduction. p75NTR functions alone, or in functional complexes with the neurotrophin receptors trkA, trkB and trkC. p75NTR signals via interaction with different transducers such as TRAF6, IRAK, and RIP-2, activating NF-κB, JNK and p38, and inactivating rhoA.1,3,6 Receptor degradation is mediated by a metalloproteinase-dependent shedding of the extracellular domain. p75NTR binds all neurotrophins with similar nM affinity, but binds pro-neurotrophins with greater affinity, and is more potently activated by pro-neurotrophins.5 Overexpression of the intracellular domain in developing neurons induces apoptosis. NGF-dependent association of NRIF with p75NTR contributes to pro-apoptotic signaling.7,8 Beta-amyloid peptide binds p75NTR and stimulates pro apoptotic signaling by p75NTR, suggesting that the receptor may be relevant for Alzheimer's disease.9

免疫原 :

Solubilized proteins from PC12 membranes.

区域 :

intracellular

Loop :

Solubilized proteins from PC12 membranes.

序列 :

Solubilized proteins from PC12 membranes.

Primary Size (Size+Units) :

1 X 10 mcg

浓度 :

1毫克/毫升

浓度 :

1毫克/毫升

缓冲液 :

磷酸盐缓冲液(PBS)

pH值 :

pH值7.4

防腐剂 :

1% BSA, 0.05% NaN3 (% of reconstituted antibody)

Additive(s) :

Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.

格式(液体/冻干) :

冻干粉末

纯化来源(杂交瘤细胞, 腹水 :

亲和纯化来自文化杂交瘤细胞培养基

储存温度 :

-20°C

UniProt数据库 :

P07174

Top Related :

蚂蚁-007

储存和重组 :

Reconstitution: 1 X 10 mcg double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

包装规格 :

产品规格/规格 :

单位 :

mcg

标价美国[美元] :

357美元

更多信息或购买 :

Alomone Labs 产品网页

公司信息

Alomone Labs

Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201

info@alomone.com

http://www.alomone.com

972-2-587-2202

公司总部: 以色列

Alomone Labs公司成立于1989年，在离子通道、GPCR及神经信号通路研究等领域占据全球领先地位。