抗体

抗Kv1.6(KCNA6)抗体

APC-003

1 X 50 mcl

530美元

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-冰冻切片

APC-003

Primary Antibody>Intracellular>Non-Labeled

Insert

抗Kv1.6(KCNA6)抗体

Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of the rat KV1.6 channel. Anti-KV1.6 (KCNA6) Antibody (#APC-003) can be used in western blot, immunohistochemistry and immunocytochemistry applications. It has been designed to recognize KV1.6 from human, rat and mouse samples.

A Rabbit Polyclonal Antibody to KV1.6 (KCNA6) Channel

BLP-PC003

KV1.6 (KCNA6), Potassium voltage-gated channel subfamily A member 6, RCK2, Human brain potassium channel 2, HBK2

KV1.6 (KCNA6) Channel

Ion Channels > K+ Channels > Voltage-Gated K+ Channels > Antibodies to KV Channels

未共轭

免疫细胞化学, IF, 免疫组化, 免疫印迹

兔

多克隆

兔IgG

KCNA6

人类(试验);小鼠(试验);大鼠(试验)

Mouse - 67/68 amino acid residues identical; human - 63/68 amino acid residues identical.

KV1.6 is a mammalian voltage-dependent K+ channel, homologous to the Drosophila Shaker K+ channel. KV1.6 was first cloned from human brain.1 Eight Shaker-related genes exist in mammals constituting the KV1 subfamily of the large KV channel family of genes.2 A functional KV1 channel is either a membrane spanning homotetramer or heterotetramer, which is composed of members of the same subfamily. In addition several auxiliary subunits and intracellular proteins might interact with the channel and affect its function. The structure of KV1.6 channel is similar to all KV channels and includes six membrane spanning helices creating a voltage sensor domain and a pore domain.2 The channel is expressed in neurons and other supporting cells in the brain, in cardiac and smooth muscle tissue as well as in ovary and testis2 and its activity influences the membrane potential and excitability of expressing cells. KV1.6 channels are sensitive to low doses of TEA (7 mM) and high doses of 4-AP (1.5 mM), the “classical” non-selective potassium channel blockers. Several toxins from snakes, scorpions and sea anemones venoms are potent blockers (affecting the channels in the nanomolar range) of KV1.6 channels. Among these the most potent and selective are α-Dendrotoxin ((9-25 nM) and δ-Dendrotoxin (23 nM), Agitoxin-2 (0.036 nM), Hongotoxin-1 (6 nM), Margatoxin (5 nM) and Stichodactyla Toxin (0.16 nM).3

谷胱甘肽S-转移酶融合蛋白

intracellular

Intracellular, C-terminus

corresponding to amino acid residues 463-530 of rat KV1.6
NYFYHRETEQEEQGQYTHVTCGQPTPDLKATDNGLGKPD
FAEASRERRSSYLPTPHRAYAEKRMLTEV,
GST fusion protein with the sequence

corresponding to amino acid residues 463-530 of rat KV1.6 (Accession P17659). Intracellular, C-terminus.
NYFYHRETEQEEQGQYTHVTCGQPTPDLKATDNGLGKPD
FAEASRERRSSYLPTPHRAYAEKRMLTEV,
GST fusion protein with the sequence

1 X 50 mcl

0.3毫克/毫升

03毫克/毫升

磷酸盐缓冲液(PBS)

pH值7.4

1% BSA, 0.05% NaN3 (% of reconstituted antibody)

Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 5% sucrose, 0.025% NaN3.

冻干粉末

The serum was depleted of anti-GST antibodies by affinity chromatography on immobilized GST and then the IgG fraction was purified on immobilized antigen

-20°C

P17659

APC-010, APC-009, APC-162, APZ-005, APC-161

Reconstitution: 1 X 50 mcl double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

1

50

mcl

530美元