产品简要
公司名称 :
Alomone Labs
产品类型 :
抗体
产品名称 :
抗Kv1.2(KCNA2)抗体
目录 :
APC-010
规格 :
25微升, 50微升, 0.2毫升
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 45
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 小鼠; 图 4a
Bull S, Bin J, Beaumont E, Boutet A, Krimpenfort P, Sadikot A, et al. Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes. J Neurosci. 2014;34:9768-78 pubmed 出版商
  • 免疫组化; 小鼠; 1:200
Buchner D, Geisinger J, Glazebrook P, Morgan M, Spiezio S, Kaiyala K, et al. The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity. Mamm Genome. 2012;23:431-42 pubmed 出版商
Mo K, Wu S, Gu X, Xiong M, Cai W, Atianjoh F, et al. MBD1 Contributes to the Genesis of Acute Pain and Neuropathic Pain by Epigenetic Silencing of Oprm1 and Kcna2 Genes in Primary Sensory Neurons. J Neurosci. 2018;38:9883-9899 pubmed 出版商
Fu L, Lv Y, Zhong Y, He Q, Liu X, Du L. Tyrosine phosphorylation of Kv1.5 is upregulated in intrauterine growth retardation rats with exaggerated pulmonary hypertension. Braz J Med Biol Res. 2017;50:e6237 pubmed 出版商
Vivekananda U, Novak P, Bello O, Korchev Y, Krishnakumar S, Volynski K, et al. Kv1.1 channelopathy abolishes presynaptic spike width modulation by subthreshold somatic depolarization. Proc Natl Acad Sci U S A. 2017;114:2395-2400 pubmed 出版商
Wolff M, Czorlich P, Nagaraj C, Schnöbel Ehehalt R, Li Y, Kwapiszewska G, et al. Amitriptyline and carbamazepine utilize voltage-gated ion channel suppression to impair excitability of sensory dorsal horn neurons in thin tissue slice: An in vitro study. Neurosci Res. 2016;109:16-27 pubmed 出版商
Sobieski C, Jiang X, Crawford D, Mennerick S. Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro. J Neurosci. 2015;35:11105-17 pubmed 出版商
Jang S, Byun J, Jeon W, Choi S, Park J, Lee B, et al. Nuclear localization and functional characteristics of voltage-gated potassium channel Kv1.3. J Biol Chem. 2015;290:12547-57 pubmed 出版商
Lv Y, Tang L, Wei J, Xu X, Gu W, Fu L, et al. Decreased Kv1.5 expression in intrauterine growth retardation rats with exaggerated pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2013;305:L856-65 pubmed 出版商
Takahashi R, Yoshizawa T, Yunoki T, Tyagi P, Naito S, de Groat W, et al. Hyperexcitability of bladder afferent neurons associated with reduction of Kv1.4 α-subunit in rats with spinal cord injury. J Urol. 2013;190:2296-304 pubmed 出版商
Zoupi L, Markoullis K, Kleopa K, Karagogeos D. Alterations of juxtaparanodal domains in two rodent models of CNS demyelination. Glia. 2013;61:1236-49 pubmed 出版商
Hao J, Padilla F, Dandonneau M, Lavebratt C, Lesage F, Noel J, et al. Kv1.1 channels act as mechanical brake in the senses of touch and pain. Neuron. 2013;77:899-914 pubmed 出版商
Horn K, Glasgow S, Gobert D, Bull S, Luk T, Girgis J, et al. DCC expression by neurons regulates synaptic plasticity in the adult brain. Cell Rep. 2013;3:173-85 pubmed 出版商
Bin J, Leong S, Bull S, Antel J, Kennedy T. Oligodendrocyte precursor cell transplantation into organotypic cerebellar shiverer slices: a model to study myelination and myelin maintenance. PLoS ONE. 2012;7:e41237 pubmed 出版商
Cazzin C, Piccoli L, Massagrande M, Garbati N, Michielin F, Knaus H, et al. rKv1.2 overexpression in the central medial thalamic area decreases caffeine-induced arousal. Genes Brain Behav. 2011;10:817-27 pubmed 出版商
Gojkovic Bukarica L, Savic N, Peric M, Markovic Lipkovski J, Cirovic S, Kanjuh V, et al. Effect of potassium channel opener pinacidil on the contractions elicited electrically or by noradrenaline in the human radial artery. Eur J Pharmacol. 2011;654:266-73 pubmed 出版商
Savvaki M, Theodorakis K, Zoupi L, Stamatakis A, Tivodar S, Kyriacou K, et al. The expression of TAG-1 in glial cells is sufficient for the formation of the juxtaparanodal complex and the phenotypic rescue of tag-1 homozygous mutants in the CNS. J Neurosci. 2010;30:13943-54 pubmed 出版商
Irani S, Alexander S, Waters P, Kleopa K, Pettingill P, Zuliani L, et al. Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. Brain. 2010;133:2734-48 pubmed 出版商
Utsunomiya I, Tanabe S, Terashi T, Ikeno S, Miyatake T, Hoshi K, et al. Identification of amino acids in the pore region of Kv1.2 potassium channel that regulate its glycosylation and cell surface expression. J Neurochem. 2010;112:913-23 pubmed 出版商
Sun W, Smith D, Fu Y, Cheng J, Bryn S, Borgens R, et al. Novel potassium channel blocker, 4-AP-3-MeOH, inhibits fast potassium channels and restores axonal conduction in injured guinea pig spinal cord white matter. J Neurophysiol. 2010;103:469-78 pubmed 出版商
Hayashi Y, Takimoto K, Chancellor M, Erickson K, Erickson V, Kirimoto T, et al. Bladder hyperactivity and increased excitability of bladder afferent neurons associated with reduced expression of Kv1.4 alpha-subunit in rats with cystitis. Am J Physiol Regul Integr Comp Physiol. 2009;296:R1661-70 pubmed 出版商
Hsiao C, Kaur G, Vong A, Bawa H, Chandler S. Participation of Kv1 channels in control of membrane excitability and burst generation in mesencephalic V neurons. J Neurophysiol. 2009;101:1407-18 pubmed 出版商
Cox R, Lozinskaya I. Ca2+ channel inactivation in small mesenteric arteries of WKY and SHR. Am J Hypertens. 2008;21:406-12 pubmed 出版商
Susuki K, Baba H, Tohyama K, Kanai K, Kuwabara S, Hirata K, et al. Gangliosides contribute to stability of paranodal junctions and ion channel clusters in myelinated nerve fibers. Glia. 2007;55:746-57 pubmed
Rivera J, Chu P, Lewis T, Arnold D. The role of Kif5B in axonal localization of Kv1 K(+) channels. Eur J Neurosci. 2007;25:136-46 pubmed
Neshatian L, Leung Y, Kang Y, Gao X, Xie H, Tsushima R, et al. Distinct modulation of Kv1.2 channel gating by wild type, but not open form, of syntaxin-1A. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1233-42 pubmed
Kuba H, Ishii T, Ohmori H. Axonal site of spike initiation enhances auditory coincidence detection. Nature. 2006;444:1069-72 pubmed
Gautier M, Hyvelin J, De Crescenzo V, Eder V, Bonnet P. Heterogeneous Kv1 function and expression in coronary myocytes from right and left ventricles in rats. Am J Physiol Heart Circ Physiol. 2007;292:H475-82 pubmed
Kleopa K, Elman L, Lang B, Vincent A, Scherer S. Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestations. Brain. 2006;129:1570-84 pubmed
Fordyce C, Jagasia R, Zhu X, Schlichter L. Microglia Kv1.3 channels contribute to their ability to kill neurons. J Neurosci. 2005;25:7139-49 pubmed
Kuba H, Yamada R, Fukui I, Ohmori H. Tonotopic specialization of auditory coincidence detection in nucleus laminaris of the chick. J Neurosci. 2005;25:1924-34 pubmed
Wang J, Weigand L, Wang W, Sylvester J, Shimoda L. Chronic hypoxia inhibits Kv channel gene expression in rat distal pulmonary artery. Am J Physiol Lung Cell Mol Physiol. 2005;288:L1049-58 pubmed
Nakayama H, Oda Y. Common sensory inputs and differential excitability of segmentally homologous reticulospinal neurons in the hindbrain. J Neurosci. 2004;24:3199-209 pubmed
Karimi Abdolrezaee S, Eftekharpour E, Fehlings M. Temporal and spatial patterns of Kv1.1 and Kv1.2 protein and gene expression in spinal cord white matter after acute and chronic spinal cord injury in rats: implications for axonal pathophysiology after neurotrauma. Eur J Neurosci. 2004;19:577-89 pubmed
Rios J, Rubin M, St Martin M, Downey R, Einheber S, Rosenbluth J, et al. Paranodal interactions regulate expression of sodium channel subtypes and provide a diffusion barrier for the node of Ranvier. J Neurosci. 2003;23:7001-11 pubmed
Dodson P, Billups B, Rusznák Z, Szucs G, Barker M, Forsythe I. Presynaptic rat Kv1.2 channels suppress synaptic terminal hyperexcitability following action potential invasion. J Physiol. 2003;550:27-33 pubmed
Popratiloff A, Giaume C, Peusner K. Developmental change in expression and subcellular localization of two shaker-related potassium channel proteins (Kv1.1 and Kv1.2) in the chick tangential vestibular nucleus. J Comp Neurol. 2003;461:466-82 pubmed
Felix R, Serrano C, Trevi o C, Mu oz Garay C, Bravo A, Navarro A, et al. Identification of distinct K+ channels in mouse spermatogenic cells and sperm. Zygote. 2002;10:183-8 pubmed
Arroyo E, Xu T, Grinspan J, Lambert S, Levinson S, Brophy P, et al. Genetic dysmyelination alters the molecular architecture of the nodal region. J Neurosci. 2002;22:1726-37 pubmed
Chittajallu R, Chen Y, Wang H, Yuan X, Ghiani C, Heckman T, et al. Regulation of Kv1 subunit expression in oligodendrocyte progenitor cells and their role in G1/S phase progression of the cell cycle. Proc Natl Acad Sci U S A. 2002;99:2350-5 pubmed
Adamson C, Reid M, Davis R. Opposite actions of brain-derived neurotrophic factor and neurotrophin-3 on firing features and ion channel composition of murine spiral ganglion neurons. J Neurosci. 2002;22:1385-96 pubmed
Chung Y, Shin C, Kim M, Cha C. Immunohistochemical study on the distribution of six members of the Kv1 channel subunits in the rat basal ganglia. Brain Res. 2000;875:164-70 pubmed
Conforti L, Bodi I, Nisbet J, Millhorn D. O2-sensitive K+ channels: role of the Kv1.2 -subunit in mediating the hypoxic response. J Physiol. 2000;524 Pt 3:783-93 pubmed
Arroyo E, Xu Y, Zhou L, Messing A, Peles E, Chiu S, et al. Myelinating Schwann cells determine the internodal localization of Kv1.1, Kv1.2, Kvbeta2, and Caspr. J Neurocytol. 1999;28:333-47 pubmed
Nashmi R, Jones O, Fehlings M. Abnormal axonal physiology is associated with altered expression and distribution of Kv1.1 and Kv1.2 K+ channels after chronic spinal cord injury. Eur J Neurosci. 2000;12:491-506 pubmed
图像
图像 1 :
Alomone Labs APC-010 图像 1
Immuno-colocalization of KV1.2 and KV1.1 in mouse cerebellum - Immunohistochemical staining of mouse perfusion-fixed frozen brain sections usingAnti-KV1.2 (KCNA2) Antibody(#APC-010) (1:300) andAnti-KV1.1 (KCNA1) (extracellular)-ATTO-594 Antibody(#APC-161-AR) (1:100). A. KV1.2 staining followed by donkey-anti-rabbit-Cy2 (green). B. KV1.1 staining (red). C. Merge of the two images suggests considerable co-localization in the pinceau structures (up-pointing arrows). KV1.1 also appears in blood vessels (down-pointing arrows) where no KV1.2 expression is observed.
图像 2 :
Alomone Labs APC-010 图像 2
GST fusion protein with the sequence YHRETEGEEQAQYLQVTSCPKIPSSPDLKK SRSASTISKSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV corresponding to amino acid residues 417-499 of rat KV1.2 (AccessionP63142). Intracellular C-terminus.
图像 3 :
Alomone Labs APC-010 图像 3
Western blot analysisof rat brain membranes: - 1.Anti-KV1.2 (KCNA2)Antibody (#APC-010) (1:200).2. Anti-KV1.2 (KCNA2) Antibody preincubated with the negative control antigen.
产品信息
供应商 :
Alomone Labs Ltd.
产品名 :
抗Kv1.2(KCNA2)抗体
目录号 :
APC-010
产品类型 :
抗体
规格 :
25微升, 50微升, 0.2毫升
同源 :
Mouse, dog, human, - identical.
同义词 :
KV1.2 (KCNA2), Potassium voltage-gated channel subfamily A member 2, RBK2
交叉活性 :
人类, 小鼠, 大鼠
应用 :
免疫细胞化学, 免疫荧光, 免疫组化, 免疫印迹
抗体类型 :
多克隆
宿主 :
共轭标签/标签/标记 :
未共轭
SwissProt号 :
P63142
浓度 :
0.8毫克/毫升
格式 :
Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 5% sucrose, 0.025% NaN3.
缓冲液 :
磷酸盐缓冲液(PBS), pH值7.4
防腐剂 :
1% BSA, 5% 蔗糖, 0.025% NaN3
包装 :
冻干粉末
储存 :
The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
纯度 :
The serum was depleted of anti-GST antibodies by affinity chromatography on immobilized GST and then the IgG fraction was purified on immobilized antigen.
抗体亚型 :
兔IgG
免疫原 :
谷胱甘肽S-转移酶融合蛋白
克隆性 :
多克隆
区域/地区/末端 :
Intracellular, C-terminus
免疫原序列 :
corresponding to amino acid residues 417-499 of rat KV1.2
SRSASTISKSDYMEIQEGVNNSNEDFREENLKTANCTLA
NTNYVNITKMLTDV,
GST fusion protein with the sequence YHRETEGEEQAQYLQVTSCPKIPSSPDLKK
类别 :
Ion Channels, voltage-gated potassium channels, voltage-gated K+ Channels
研究领域(s) :
癫痫, 神经科学
更多信息或购买 :
公司信息
Alomone Labs
Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201
info@alomone.com
http://www.alomone.com
972-2-587-2202
公司总部: 以色列
Alomone Labs公司成立于1989年,在离子通道、GPCR及神经信号通路研究等领域占据全球领先地位。