抗Kv2.1抗体 | Alomone Labs APC-012 产品信息

产品简要

公司名称 :

Alomone Labs

产品类型 :

抗体

产品名称 :

抗Kv2.1抗体

APC-012

规格 :

1 X 50 mcl

价格 :

530美元

克隆性 :

多克隆

宿主 :

domestic rabbit

共轭标签 :

未共轭

反应物种 :

人类, 小鼠, 大鼠

应用 :

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀

更多信息或购买 :

Alomone Labs 产品网页

文章摘录数: 8

参考文献
Joseph L, Reyes M, Homan E, Gowen B, Avula U, Goulbourne C, et al. The mitochondrial calcium uniporter promotes arrhythmias caused by high-fat diet. Sci Rep. 2021;11:17808 pubmed 出版商
Lee M, Nahorski M, Hockley J, Lu V, Ison G, Pattison L, et al. Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel KV6.4 Subunit. Cell Rep. 2020;32:107941 pubmed 出版商
Greitzer Antes D, Xie L, Qin T, Xie H, Zhu D, Dolai S, et al. Kv2.1 clusters on β-cell plasma membrane act as reservoirs that replenish pools of newcomer insulin granule through their interaction with syntaxin-3. J Biol Chem. 2018;293:6893-6904 pubmed 出版商
Fu L, Lv Y, Zhong Y, He Q, Liu X, Du L. Tyrosine phosphorylation of Kv1.5 is upregulated in intrauterine growth retardation rats with exaggerated pulmonary hypertension. Braz J Med Biol Res. 2017;50:e6237 pubmed 出版商
Justice J, Schulien A, He K, Hartnett K, Aizenman E, Shah N. Disruption of KV2.1 somato-dendritic clusters prevents the apoptogenic increase of potassium currents. Neuroscience. 2017;354:158-167 pubmed 出版商
Regnier G, Bocksteins E, Van de Vijver G, Snyders D, Van Bogaert P. The contribution of Kv2.2-mediated currents decreases during the postnatal development of mouse dorsal root ganglion neurons. Physiol Rep. 2016;4: pubmed 出版商
Wolff M, Czorlich P, Nagaraj C, SchnÃ¶bel Ehehalt R, Li Y, Kwapiszewska G, et al. Amitriptyline and carbamazepine utilize voltage-gated ion channel suppression to impair excitability of sensory dorsal horn neurons in thin tissue slice: An in vitro study. Neurosci Res. 2016;109:16-27 pubmed 出版商
Peltola M, Kuja Panula J, Liuhanen J, VÃµikar V, Piepponen P, Hiekkalinna T, et al. AMIGO-Kv2.1 Potassium Channel Complex Is Associated With Schizophrenia-Related Phenotypes. Schizophr Bull. 2016;42:191-201 pubmed 出版商

图像

图像 1 :

Western blot analysis of rat brain membranes: - 1. Anti-KV2.1 Antibody (#APC-012), (1:500).2. Anti-KV2.1 Antibody, preincubated with KV2.1 Blocking Peptide (BLP-PC012).

图像 2 :

Expression of KV2.1 channel in rat pancreas - Immunohistochemical staining of rat paraffin embedded pancreas sections using Anti-KV2.1 Antibody (#APC-012), (1:50), followed by goat anti-rabbit-AlexaFluor-555 secondary antibody. Endocrine (Islets of Langerhans) and exocrine areas of pancreas section are shown. Strong and highly specific KV2.1 staining is evident only in endocrine cells (red). Hoechst 33342 is used as the counterstain (blue).

图像 3 :

Western blot analysisof rat brain membranes: - 1.Anti-KV2.1Antibody (#APC-012) (1:500).2. Anti-KV2.1 Antibody preincubated with the control peptide antigen.

产品信息

SKU号 :

APC-012_1_50_mcl

ParentSKU :

APC-012

Taxonomy Node :

Primary Antibody>Intracellular>Non-Labeled

Action :

Insert

产品名称 :

抗Kv2.1抗体

产品描述 :

Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of the rat KV2.1 channel. Anti-KV2.1 Antibody (#APC-012) can be used in western blot, immunoprecipitation, immunocytochemistry, and immunohistochemistry applications. It has been designed to recognize KV2.1 from rat, human, and mouse samples.

Short Description :

A Rabbit Polyclonal Antibody to KV2.1 Channel

Negative Control :

BLP-PC012

同义词 :

KV2.1, KCNB1, DRK1, Delayed rectifier potassium channel 1, Potassium voltage-gated channel subfamily B member 1

靶标名 :

KV2.1 Channel

Primary Category (Old) :

Ion Channels > K+ Channels > Voltage-Gated K+ Channels > Antibodies to KV Channels

标记/共轭标签 :

未共轭

应用 :

免疫细胞化学, IF, 免疫组化, 免疫沉淀, 免疫印迹

宿主 :

兔

克隆性 :

多克隆

抗体亚型 :

兔IgG

基因符号 :

KCNB1

反应物种 :

人类(试验);小鼠(试验);大鼠(试验)

同源 :

Mouse - identical; human, rabbit - 15/17 amino acid residues identical.

靶标/背景信息 :

KV2.1 is a member of the voltage-gated K+ channel superfamily. Together with the closely related KV2.2 protein they form the KV2 subfamily also known as Shab.1 As with all KV channels, KV2.1 possesses the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. The functional KV channel is a tetramer that can either be a homotetramer or a heteromer of KV2.1 and KV2.2 subunits. Both KV2.1 and KV2.2 channels are known as delayed rectifiers that is, channels that are activated by changes in membrane potential (depolarization) but inactivate very slowly. The current they form is known as IK or IDR. Accessory subunits such as KChaP and the electrically silent a subunits KV8 and KV9 can modulate biochemical and biophysical properties of KV2.1.2 KV2.1 is widely expressed throughout the body including brain, lung, pancreas, skeletal muscle and pulmonary artery.2 The main function of KV2.1 is to maintain membrane potential and to modulate the electrical excitability in neurons and muscle. In rat pulmonary artery it probably mediates hypoxic pulmonary vasoconstriction together with the KV9.3 subunit.3 Several toxins from spider venoms are potent blockers (affecting the channels in the nanomolar range) of KV2.1 channels. Among these the most potent and selective are Stromatoxin-1 (#STS-350), (12.7 nM)4 and Hanatoxin (42 nM).4

免疫原 :

合成肽

区域 :

intracellular

Loop :

Intracellular, C-terminus

序列 :

(CY)HMLPGGGAHGSTRDQSI, corresponding to amino acid residues 841-857 of rat KV2.1

序列文本 :

Peptide (CY)HMLPGGGAHGSTRDQSI, corresponding to amino acid residues 841-857 of rat KV2.1 (Accession P15387). Intracellular, C-terminus.

Primary Size (Size+Units) :

1 X 50 mcl

浓度 :

1毫克/毫升

浓度 :

1毫克/毫升

缓冲液 :

磷酸盐缓冲液(PBS)

pH值 :

pH值7.4

防腐剂 :

1% BSA, 0.05% NaN3 (% of reconstituted antibody)

Additive(s) :

Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.

格式(液体/冻干) :

冻干粉末

纯化来源(杂交瘤细胞, 腹水 :

IgG fraction purified on immobilized Protein A

储存温度 :

-20°C

UniProt数据库 :

P15387

Top Related :

APC-004, APC-120, STG-200, APC-010, APC-009

储存和重组 :

Reconstitution: 1 X 50 mcl double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

包装规格 :

产品规格/规格 :

单位 :

mcl

标价美国[美元] :

530美元

更多信息或购买 :

Alomone Labs 产品网页

公司信息

Alomone Labs

Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201

info@alomone.com

http://www.alomone.com

972-2-587-2202

公司总部: 以色列

Alomone Labs公司成立于1989年，在离子通道、GPCR及神经信号通路研究等领域占据全球领先地位。