抗体

抗Kv4.3抗体

APC-017

1 X 25 mcl

425美元

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀

APC-017

Primary Antibody>Intracellular>Non-Labeled

Insert

抗Kv4.3抗体

Anti-KV4.3 Antibody (#APC-017) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot, immunoprecipitation, immunocytochemistry, and immunohistochemistry applications. It has been designed to recognize KV4.3 from human, rat, and mouse samples.

A Rabbit Polyclonal Antibody to KV4.3 Channel

BLP-PC017

KV4.3, Voltage-gated K+ channel subfamily D member 3, KCND3

KV4.3 Channel

Ion Channels > K+ Channels > Voltage-Gated K+ Channels > Antibodies to KV Channels

未共轭

免疫细胞化学, IF, 免疫组化, 免疫沉淀, 免疫印迹

兔

多克隆

兔IgG

KCND3

人类(试验);小鼠(试验);大鼠(试验)

Rat, rabbit - identical; mouse - 16/17 amino acid residues identical.

KV4.3 is a voltage-dependent K+ channel that belongs to the Shal channel subfamily and includes two other members: KV4.1 and KV4.2. KV4.3 possesses the signature structure of the voltage-dependent K+ channels; six membrane-spanning domains with intracellular N and C termini. As with other members of the voltage-gated K+ channel superfamily, the functional channel is a tetramer that can be composed of more than one member of the Shal subfamily, i.e. heterotetramers of KV4.1 and KV4.2. The KV4 channels are characterized by activation at subthreshold membrane potentials, rapid inactivation and fast recovery from inactivation compared with other voltage-dependent K+ channels. This type of current is known as transient A-type K+ currents.1 The biophysical properties of the KV4.3 subunit can be modified by its association with auxiliary β subunits such as the KChIP family that increases current densities and accelerates both the inactivation and the recovery time. KV4.3 is highly expressed in the brain where it has a key role in shaping the action potential and firing frequency of neurons. In the heart, together with KV4.2, it underlies the fast inactivating and recovering cardiac transient outward current Ito.2,3 The channel is also expressed in smooth muscle cells of several organs such as myometrium, lung and colon where its function has not been completely elucidated. Several toxins from spider venoms are potent blockers (affecting the channels in the nanomolar range) of KV4.3 channels. Among these the most potent and selective are Phrixotoxin-1 (#STP-700) (28 nM) and Phrixotoxin-2 (#STP-710) (71 nM).4

合成肽

intracellular

Intracellular, C-terminus

(C)NEALELTGTPEEEHMGK, corresponding to amino acid residues 451-468 of human KV4.3

Peptide (C)NEALELTGTPEEEHMGK, corresponding to amino acid residues 451-468 of human KV4.3 (Accession O60577). Intracellular, C-terminus.

1 X 25 mcl

0.8毫克/毫升

08毫克/毫升

磷酸盐缓冲液(PBS)

pH值7.4

1% BSA, 0.05% NaN3 (% of reconstituted antibody)

Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.

冻干粉末

Affinity purified on immobilized antigen

-20°C

O60577

APC-023, APC-022, ACC-003, ASC-005, APC-007

Reconstitution: 1 X 25 mcl double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

1

25

mcl

425美元