抗KCNMA1(KCa1.1)(1097-1196)抗体 | Alomone Labs APC-021 产品信息

产品简要

公司名称 :

Alomone Labs

产品类型 :

抗体

产品名称 :

抗KCNMA1(KCa1.1)(1097-1196)抗体

APC-021

规格 :

1 X 25 mcl

价格 :

425美元

克隆性 :

多克隆

宿主 :

domestic rabbit

共轭标签 :

未共轭

反应物种 :

人类, 小鼠, 大鼠

应用 :

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀

更多信息或购买 :

Alomone Labs 产品网页

文章摘录数: 25

出版应用/物种/样本/稀释	参考文献
免疫细胞化学; 小鼠; 1:100; 图 3 免疫印迹; 小鼠; 1:1000; 图 1	Li Y, Hu H, Butterworth M, Tian J, Zhu M, O Neil R. Expression of a Diverse Array of Ca2+-Activated K+ Channels (SK1/3, IK1, BK) that Functionally Couple to the Mechanosensitive TRPV4 Channel in the Collecting Duct System of Kidney. PLoS ONE. 2016;11:e0155006 pubmed 出版商
免疫沉淀; 小鼠; 图 1 免疫细胞化学; 人类; 2 ug/ml; 图 2	Singh H, Li M, Hall L, Chen S, Sukur S, Lu R, et al. MaxiK channel interactome reveals its interaction with GABA transporter 3 and heat shock protein 60 in the mammalian brain. Neuroscience. 2016;317:76-107 pubmed 出版商
	Ohya S, Kajikuri J, Endo K, Kito H, Elboray E, Suzuki T. Ca2+ -activated K+ channel KCa 1.1 as a therapeutic target to overcome chemoresistance in three-dimensional sarcoma spheroid models. Cancer Sci. 2021;112:3769-3783 pubmed 出版商
	Sung C, Chen M, Lin Y, Lin Y, Lin Y, Yang S, et al. Urinary Extracellular Vesicles for Renal Tubular Transporters Expression in Patients With Gitelman Syndrome. Front Med (Lausanne). 2021;8:679171 pubmed 出版商
	Fu X, An Y, Wang H, Li P, Lin J, Yuan J, et al. Deficiency of Klc2 Induces Low-Frequency Sensorineural Hearing Loss in C57BL/6 J Mice and Human. Mol Neurobiol. 2021;: pubmed 出版商
	Xu X, Li Y, Wu Y, Xu Y, Weng R, Wang C, et al. Upregulation of spinal ASIC1 by miR-485 mediates enterodynia in adult offspring rats with prenatal maternal stress. CNS Neurosci Ther. 2021;27:244-255 pubmed 出版商
	Bai J, Xue N, Lawal O, Nyati A, Santos Sacchi J, Navaratnam D. Calcium-induced calcium release in proximity to hair cell BK channels revealed by PKA activation. Physiol Rep. 2020;8:e14449 pubmed 出版商
	Chen S, Feng X, Chen X, Zhuang Z, Xiao J, Fu H, et al. 14-3-3γ, a novel regulator of the large-conductance Ca2+-activated K+ channel. Am J Physiol Renal Physiol. 2020;319:F52-F62 pubmed 出版商
	Zhao H, Xue Q, Li C, Wang Q, Han S, Zhou Y, et al. Upregulation of Beta4 subunit of BKCa channels in the anterior cingulate cortex contributes to mechanical allodynia associated anxiety-like behaviors. Mol Brain. 2020;13:22 pubmed 出版商
	Yang X, Wang G, Cao T, Zhang L, Ma Y, Jiang S, et al. Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia. J Biol Chem. 2019;294:12921-12932 pubmed 出版商
	Barone C, Douma S, Reijntjes D, Browe B, K ppl C, Klump G, et al. Altered cochlear innervation in developing and mature naked and Damaraland mole rats. J Comp Neurol. 2019;527:2302-2316 pubmed 出版商
	Lu T, Chai Q, Jiao G, Wang X, Sun X, Furuseth J, et al. Downregulation of BK channel function and protein expression in coronary arteriolar smooth muscle cells of type 2 diabetic patients. Cardiovasc Res. 2019;115:145-153 pubmed 出版商
	Goswami S, Ponnalagu D, Hussain A, Shah K, Karekar P, Gururaja Rao S, et al. Expression and Activation of BKCa Channels in Mice Protects Against Ischemia-Reperfusion Injury of Isolated Hearts by Modulating Mitochondrial Function. Front Cardiovasc Med. 2018;5:194 pubmed 出版商
	Wolter S, Möhrle D, Schmidt H, Pfeiffer S, Zelle D, Eckert P, et al. GC-B Deficient Mice With Axon Bifurcation Loss Exhibit Compromised Auditory Processing. Front Neural Circuits. 2018;12:65 pubmed 出版商
	Li Y, Hu H, O Neil R. Caveolae facilitate TRPV4-mediated Ca2+ signaling and the hierarchical activation of Ca2+-activated K+ channels in K+-secreting renal collecting duct cells. Am J Physiol Renal Physiol. 2018;315:F1626-F1636 pubmed 出版商
	Pritchard H, Pires P, Yamasaki E, Thakore P, Earley S. Nanoscale remodeling of ryanodine receptor cluster size underlies cerebral microvascular dysfunction in Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 2018;115:E9745-E9752 pubmed 出版商
	Pritchard H, Gonzales A, Pires P, Drumm B, Ko E, Sanders K, et al. Microtubule structures underlying the sarcoplasmic reticulum support peripheral coupling sites to regulate smooth muscle contractility. Sci Signal. 2017;10: pubmed 出版商
	Zhang Y, Zhang Z, Xiao S, Tien J, Le S, Le T, et al. Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning. Neuron. 2017;95:1103-1111.e4 pubmed 出版商
	Baker D, Pryce G, Visintin C, Sisay S, Bondarenko A, Vanessa Ho W, et al. Big conductance calcium-activated potassium channel openers control spasticity without sedation. Br J Pharmacol. 2017;174:2662-2681 pubmed 出版商
	Zaman T, de Oliveira C, Smoka M, Narla C, Poulter M, Schmid S. BK Channels Mediate Synaptic Plasticity Underlying Habituation in Rats. J Neurosci. 2017;37:4540-4551 pubmed 出版商
	Nystoriak M, Nieves Cintrón M, Patriarchi T, Buonarati O, Prada M, Morotti S, et al. Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Sci Signal. 2017;10: pubmed 出版商
	Ren J, Xin F, Liu P, Zhao H, Zhang S, Han P, et al. Role of BKCa in Stretch-Induced Relaxation of Colonic Smooth Muscle. Biomed Res Int. 2016;2016:9497041 pubmed 出版商
	Velázquez Marrero C, Burgos A, García J, Palacio S, Marrero H, Bernardo A, et al. Alcohol Regulates BK Surface Expression via Wnt/?-Catenin Signaling. J Neurosci. 2016;36:10625-10639 pubmed
	Perry M, Rajendran V, MacLennan K, Sandle G. Segmental differences in upregulated apical potassium channels in mammalian colon during potassium adaptation. Am J Physiol Gastrointest Liver Physiol. 2016;311:G785-G793 pubmed 出版商
	Zhang J, Li M, Zhang Z, Zhu R, Olcese R, Stefani E, et al. The mitochondrial BKCa channel cardiac interactome reveals BKCa association with the mitochondrial import receptor subunit Tom22, and the adenine nucleotide translocator. Mitochondrion. 2017;33:84-101 pubmed 出版商

图像

图像 1 :

Western blot analysis of rat brain membranes: - 1. Anti-KCNMA1 (KCa1.1) (1097-1196) Antibody (#APC-021), (1:200).2. Anti-KCNMA1 (KCa1.1) (1097-1196) Antibody, preincubated with KCNMA1 (KCa1.1) (1097-1196) Blocking Peptide (#BLP-PC021).

图像 2 :

SHSSHSSQSSSKKSSSVHSIPSTANRPNRPKSRESRDKQNATRMTRMGQAEKKWFTDEPDNAYPRNIQIKPMSTHMANQINQYKSTSSLIPPIREVEDEC corresponding to residues 1097-1196 of mouse KCNMA1variant 2 (AccessionQ08460-2). Intracellular C-terminus.

图像 3 :

Expression of KCa1.1 in mouse SAN cells. - Immunocytochemical staining of mouse sinoatrial cells (SANCs) using Anti-KCNMA1 (KCa1.1) (1097-1196) Antibody (#APC-021). BK channel expression (red) overlaps with that of HCN4 (green). No detection of KCa1.1 was observed with the secondary antibody.Adapted from Lai M.H. et al. (2014) with permission of the American Physiological Society.

产品信息

SKU号 :

APC-021_1_25_mcl

ParentSKU :

APC-021

Taxonomy Node :

Primary Antibody>Intracellular>Non-Labeled

Action :

Insert

产品名称 :

抗KCNMA1(KCa1.1)(1097-1196)抗体

产品描述 :

Anti-KCNMA1 (KCa1.1) (1097-1196) Antibody (#APC-021) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot, immunoprecipitation, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize KCNMA1 from human, mouse, and rat samples.

Short Description :

A Rabbit Polyclonal Antibody to KCNMA1 (KCa1.1) Channel

Negative Control :

BLP-PC021

同义词 :

KCNMA1 (KCa1.1), Large conductance calcium-activated potassium channel subfamily M subunit alpha-1, BKCa alpha, Maxi K+, Slo1

靶标名 :

KCNMA1 (KCa1.1) Channel

Primary Category (Old) :

Ion Channels > K+ Channels > Ca2+-Activated K+ Channels > Antibodies to KCa Channels

标记/共轭标签 :

未共轭

应用 :

免疫细胞化学, IF, 免疫组化, 免疫沉淀, 免疫印迹

宿主 :

兔

克隆性 :

多克隆

抗体亚型 :

兔IgG

基因符号 :

KCNMA1

反应物种 :

小鼠(试验);大鼠(试验)

同源 :

Chicken - 91/99 amino acid residues identical; rabbit - 88/99 amino acid residues identical; turtle - 87/99 amino acid residues identical.

靶标/背景信息 :

The KCa1.1 channel (also known as KCNMA1, BKCa, Maxi K+ or slo) is part of a structurally diverse group of K+ channels that are activated by an increase in intracellular Ca2+. KCa1.1 shows a large single channel conductance when recorded electrophysiologically and hence its name. It differs from the rest of the subfamily members in that it can be activated by both an increase in intracellular Ca2+ and by membrane depolarization. In addition, the KCa1.1 channel structurally differs from the other Ca2+-dependent K+ channels. While the latter group has a topology that resembles that of the voltage-dependent K+ channels, the KCa1.1 channel has an extracellular N-terminus domain as well as an additional transmembrane domain. KCa1.1 is expressed in virtually all cell types where it causes hyperpolarization and helps to connect intracellular Ca2+ signaling pathways and membrane excitability. Indeed, KCa1.1 channels play a crucial role in smooth muscle contractility, neuronal spike shaping and neurotransmitter release.

免疫原 :

谷胱甘肽S-转移酶融合蛋白

区域 :

intracellular

Loop :

Intracellular, C-terminus

序列 :

corresponding to residues 1097-1196 of mouse KCNMA1 variant 2
SHSSHSSQSSSKKSSSVHSIPSTANRPNRPKSRESRDKQ
NATRMTRMGQAEKKWFTDEPDNAYPRNIQIKPMSTHMAN
QINQYKSTSSLIPPIREVEDEC,

序列文本 :

corresponding to residues 1097-1196 of mouse KCNMA1 variant 2 (Accession Q08460-2). Intracellular, C-terminus.
sequenceSHSSHSSQSSSKKSSSVHSIPSTANRPNRPK
SRESRDKQNATRMTRMGQAEKKWFTDEPDNAYPRNIQIK
PMSTHMANQINQYKSTSSLIPPIREVEDEC,
GST fusion protein with the

Primary Size (Size+Units) :

1 X 25 mcl

浓度 :

0.4毫克/毫升

浓度 :

04毫克/毫升

缓冲液 :

磷酸盐缓冲液(PBS)

pH值 :

pH值7.4

防腐剂 :

1% BSA, 0.05% NaN3 (% of reconstituted antibody)

Additive(s) :

Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.

格式(液体/冻干) :

冻干粉末

纯化来源(杂交瘤细胞, 腹水 :

The serum was depleted of anti-GST antibodies by affinity chromatography on immobilized GST and then the IgG fraction was purified on immobilized antigen

储存温度 :

-20°C

UniProt数据库 :

Q08460-2

Top Related :

APC-107, APC-036, ACC-005, ACC-003, APC-151

储存和重组 :

Reconstitution: 1 X 25 mcl double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

包装规格 :

产品规格/规格 :

单位 :

mcl

标价美国[美元] :

425美元

更多信息或购买 :

Alomone Labs 产品网页

公司信息

Alomone Labs

Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201

info@alomone.com

http://www.alomone.com

972-2-587-2202

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Alomone Labs公司成立于1989年，在离子通道、GPCR及神经信号通路研究等领域占据全球领先地位。