抗KCNQ1抗体 | Alomone Labs APC-022 产品信息

产品简要

公司名称 :

Alomone Labs

产品类型 :

抗体

产品名称 :

抗KCNQ1抗体

APC-022

规格 :

1 X 25 mcl

价格 :

425美元

克隆性 :

多克隆

宿主 :

domestic rabbit

共轭标签 :

未共轭

反应物种 :

人类, 小鼠, 大鼠

应用 :

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-冰冻切片

更多信息或购买 :

Alomone Labs 产品网页

文章摘录数: 17

出版应用/物种/样本/稀释	参考文献
免疫组化-冰冻切片; 人类; 1:100; 图 8	Liu W, Edin F, Blom H, Magnusson P, Schrott Fischer A, Glueckert R, et al. Super-resolution structured illumination fluorescence microscopy of the lateral wall of the cochlea: the Connexin26/30 proteins are separately expressed in man. Cell Tissue Res. 2016;365:13-27 pubmed 出版商
	Kabakov A, Sengun E, Lu Y, Roder K, Bronk P, Baggett B, et al. Three-Week-Old Rabbit Ventricular Cardiomyocytes as a Novel System to Study Cardiac Excitation and EC Coupling. Front Physiol. 2021;12:672360 pubmed 出版商
	Gou X, Hu T, Gou Y, Li C, Yi M, Jia M. Specific protein kinase C isoform exerts chronic inhibition on the slowly activating delayed-rectifier potassium current by affecting channel trafficking. Channels (Austin). 2021;15:262-272 pubmed 出版商
	Carll A, Salatini R, Pirela S, Wang Y, Xie Z, Lorkiewicz P, et al. Inhalation of printer-emitted particles impairs cardiac conduction, hemodynamics, and autonomic regulation and induces arrhythmia and electrical remodeling in rats. Part Fibre Toxicol. 2020;17:7 pubmed 出版商
	Tian C, Johnson K. TBX1 is required for normal stria vascularis and semicircular canal development. Dev Biol. 2020;457:91-103 pubmed 出版商
	Inagaki A, Hayashi M, Andharia N, Matsuda H. Involvement of butyrate in electrogenic K+ secretion in rat rectal colon. Pflugers Arch. 2019;471:313-327 pubmed 出版商
	Zankov D, Salloum F, Jiang M, Tseng G. Chronic in vivo angiotensin II administration differentially modulates the slow delayed rectifier channels in atrial and ventricular myocytes. Heart Rhythm. 2019;16:108-116 pubmed 出版商
	Lv Y, Wang Y, Zhu X, Zhang H. Aldosterone downregulates delayed rectifier potassium currents through an angiotensin type 1 receptor-dependent mechanism. Am J Transl Res. 2018;10:1413-1421 pubmed
	Lai Y, Li N, Lawrence W, Wang S, Levine A, Burchhardt D, et al. Myocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy. Epilepsia Open. 2018;3:213-223 pubmed 出版商
	Meisel E, Tobelaim W, Dvir M, Haitin Y, Peretz A, Attali B. Inactivation gating of Kv7.1 channels does not involve concerted cooperative subunit interactions. Channels (Austin). 2018;12:89-99 pubmed 出版商
	Masuda K, Takanari H, Morishima M, Ma F, Wang Y, Takahashi N, et al. Testosterone-mediated upregulation of delayed rectifier potassium channel in cardiomyocytes causes abbreviation of QT intervals in rats. J Physiol Sci. 2018;68:759-767 pubmed 出版商
	Kanner S, Morgenstern T, Colecraft H. Sculpting ion channel functional expression with engineered ubiquitin ligases. elife. 2017;6: pubmed 出版商
	Tommiska J, Känsäkoski J, Skibsbye L, Vaaralahti K, Liu X, Lodge E, et al. Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis. Nat Commun. 2017;8:1289 pubmed 出版商
	Piccini I, Fehrmann E, Frank S, Müller F, Greber B, Seebohm G. Adrenergic Stress Protection of Human iPS Cell-Derived Cardiomyocytes by Fast Kv7.1 Recycling. Front Physiol. 2017;8:705 pubmed 出版商
	Moreno C, Oliveras A, Bartolucci C, Munoz C, de la Cruz A, Peraza D, et al. D242N, a KV7.1 LQTS mutation uncovers a key residue for IKs voltage dependence. J Mol Cell Cardiol. 2017;110:61-69 pubmed 出版商
	Bientinesi R, Mancuso C, Martire M, Bassi P, Sacco E, Currò D. KV7 channels in the human detrusor: channel modulator effects and gene and protein expression. Naunyn Schmiedebergs Arch Pharmacol. 2017;390:127-137 pubmed 出版商
	Opthof T, Remme C, Jorge E, Noriega F, Wiegerinck R, Tasiam A, et al. Cardiac activation-repolarization patterns and ion channel expression mapping in intact isolated normal human hearts. Heart Rhythm. 2017;14:265-272 pubmed 出版商

图像

图像 1 :

Western blot analysis of rat heart membranes: - 1. Anti-KCNQ1 Antibody (#APC-022), (1:200). 2. Anti-KCNQ1 Antibody, preincubated with KCNQ1 Blocking Peptide (#BLP-PC022).

图像 2 :

Expression of KCNQ1 (KV7.1) and KCNQ5 (KV7.5) in rat smooth muscle cells. - Immunocytochemical staining of rat smooth muscle cells from LCA and RCA using Anti-KCNQ1 Antibody (#APC-022) and Anti-KCNQ5 Antibody (#APC-155) shows that the expression of both channels is higher in LCA than in RCA.Adapted from Morales-Cano D. et al. (2015) with permission of the European Society of Cardiology.

产品信息

SKU号 :

APC-022_1_25_mcl

ParentSKU :

APC-022

Taxonomy Node :

Primary Antibody>Intracellular>Non-Labeled

Action :

Insert

产品名称 :

抗KCNQ1抗体

产品描述 :

Anti-KCNQ1 Antibody (#APC-022) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot, immunoprecipitaion, immunohistochemistry and immunocytochemistry applications. It has been designed to recognize KV7.1 channel from rat, human, and mouse samples.

Short Description :

A Rabbit Polyclonal Antibody to KCNQ1 (KV7.1) Channel

Negative Control :

BLP-PC022

同义词 :

KCNQ1, KV7.1, Voltage-gated potassium channel QKT subfamily member 1, KvLQT1

靶标名 :

KCNQ1 (KV7.1) Channel

Primary Category (Old) :

Ion Channels > K+ Channels > Voltage-Gated K+ Channels > Antibodies to KV Channels

标记/共轭标签 :

未共轭

应用 :

免疫细胞化学, IF, 免疫组化, 免疫沉淀, 免疫印迹

宿主 :

兔

克隆性 :

多克隆

抗体亚型 :

兔IgG

基因符号 :

KCNQ1

反应物种 :

人类(试验);小鼠(试验);大鼠(试验)

同源 :

Rat, mouse - 14/16 amino acid residues identical.

靶标/背景信息 :

KCNQ1 (KV7.1) is part of a voltage-gated K+ family that includes 5 other members (KCNQ1-5). The channel has been intensively studied since it was found that together with MinK (Isk) it underlay the cardiac Iks current that controls the duration of the action potential of the human heart. Indeed mutations on either KV7.1 or MinK can be responsible for long QT syndrome, a cardiac disorder that causes arrhythmias and sudden death. Although KV7.1 expression and function has been mainly investigated in relation with cardiac function the channel is widely distributed in epithelial tissues. There it has been implicated in physiological functions such as the regulation of acid secretion in the stomach and Cl- secretion into the colon.

免疫原 :

合成肽

区域 :

intracellular

Loop :

Intracellular, C-terminus

序列 :

(C)TYEQLTVPRRGPDEGS, corresponding to amino acid residues 661-676 of human KCNQ1

序列文本 :

Peptide (C)TYEQLTVPRRGPDEGS, corresponding to amino acid residues 661-676 of human KCNQ1 (Accession P51787). Intracellular, C-terminus.

Primary Size (Size+Units) :

1 X 25 mcl

浓度 :

0.75毫克/毫升

浓度 :

075毫克/毫升

缓冲液 :

磷酸盐缓冲液(PBS)

pH值 :

pH值7.4

防腐剂 :

1% BSA, 0.05% NaN3 (% of reconstituted antibody)

Additive(s) :

Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.

格式(液体/冻干) :

冻干粉末

纯化来源(杂交瘤细胞, 腹水 :

Affinity purified on immobilized antigen

储存温度 :

-20°C

UniProt数据库 :

P51787

Top Related :

APC-062, ACC-003, ASC-005, APC-017, APC-163

储存和重组 :

Reconstitution: 1 X 25 mcl double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

包装规格 :

产品规格/规格 :

单位 :

mcl

标价美国[美元] :

425美元

更多信息或购买 :

Alomone Labs 产品网页

公司信息

Alomone Labs

Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201

info@alomone.com

http://www.alomone.com

972-2-587-2202

公司总部: 以色列

Alomone Labs公司成立于1989年，在离子通道、GPCR及神经信号通路研究等领域占据全球领先地位。