抗Kv4.2抗体 | Alomone Labs APC-023 产品信息

产品简要

公司名称 :

Alomone Labs

产品类型 :

抗体

产品名称 :

抗Kv4.2抗体

APC-023

规格 :

1 X 25 mcl

价格 :

425美元

克隆性 :

多克隆

宿主 :

domestic rabbit

共轭标签 :

未共轭

反应物种 :

人类, 小鼠, 大鼠

应用 :

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀

更多信息或购买 :

Alomone Labs 产品网页

文章摘录数: 10

参考文献
Kim K, Jeong H, Kim Y, Lee S, Kim Y, Kim H, et al. Calbindin regulates Kv4.1 trafficking and excitability in dentate granule cells via CaMKII-dependent phosphorylation. Exp Mol Med. 2021;53:1134-1147 pubmed 出版商
Pluteanu F, Seidl M, Hamer S, Scholz B, Müller F. Inward Rectifier K+ Currents Contribute to the Proarrhythmic Electrical Phenotype of Atria Overexpressing Cyclic Adenosine Monophosphate Response Element Modulator Isoform CREM-IbΔC-X. J Am Heart Assoc. 2020;9:e016144 pubmed 出版商
S xe1 nchez Aguilera A, Monedero G, Colino A, Vicente Torres M. Development of Action Potential Waveform in Hippocampal CA1 Pyramidal Neurons. Neuroscience. 2020;442:151-167 pubmed 出版商
Kim K, Lee S, Yoon S, Kim Y, Jeong H, Lee S, et al. Kv4.1, a Key Ion Channel For Low Frequency Firing of Dentate Granule Cells, Is Crucial for Pattern Separation. J Neurosci. 2020;40:2200-2214 pubmed 出版商
Carll A, Salatini R, Pirela S, Wang Y, Xie Z, Lorkiewicz P, et al. Inhalation of printer-emitted particles impairs cardiac conduction, hemodynamics, and autonomic regulation and induces arrhythmia and electrical remodeling in rats. Part Fibre Toxicol. 2020;17:7 pubmed 出版商
Welch M, Forster L, Atlas S, Baro D. SUMOylating Two Distinct Sites on the A-type Potassium Channel, Kv4.2, Increases Surface Expression and Decreases Current Amplitude. Front Mol Neurosci. 2019;12:144 pubmed 出版商
Alfaro Ruiz R, Aguado C, Martín Belmonte A, Moreno Martínez A, Lujan R. Expression, Cellular and Subcellular Localisation of Kv4.2 and Kv4.3 Channels in the Rodent Hippocampus. Int J Mol Sci. 2019;20: pubmed 出版商
Day S, Yang W, Ewin S, Zhou X, Ma T. Glucagon-like peptide-1 cleavage product GLP-1 (9-36) amide enhances hippocampal long-term synaptic plasticity in correlation with suppression of Kv4.2 expression and eEF2 phosphorylation. Hippocampus. 2017;27:1264-1274 pubmed 出版商
Liu X, Zhang Y, Du W, Liang H, He H, Zhang L, et al. MiR-223-3p as a Novel MicroRNA Regulator of Expression of Voltage-Gated K+ Channel Kv4.2 in Acute Myocardial Infarction. Cell Physiol Biochem. 2016;39:102-14 pubmed 出版商
Wolff M, Czorlich P, Nagaraj C, SchnÃ¶bel Ehehalt R, Li Y, Kwapiszewska G, et al. Amitriptyline and carbamazepine utilize voltage-gated ion channel suppression to impair excitability of sensory dorsal horn neurons in thin tissue slice: An in vitro study. Neurosci Res. 2016;109:16-27 pubmed 出版商

图像

图像 1 :

Western blot analysis of rat brain membranes: - 1. Anti-KV4.2 Antibody (#APC-023), (1:200).2. Anti-KV4.2 Antibody, preincubated with Kv4.2 Blocking Peptide (#BLP-PC023).

图像 2 :

Peptide (C)SNQLQSSEDEPAFVSK corresponding to amino acid residues 454-469 of rat KV4.2 (AccessionQ63881). Intracellular C-terminus.

图像 3 :

Alomone Labs A-794278inhibits mGluR1-mediated Ca2+mobilization in U2OS cells. - Dose-response ofA-794278(#A-435) normalized inhibition of human mGluR1-mediated L-glutamate-evoked Ca2+mobilization. Cells were loaded with calcium-sensitive dye incubated with a range of A-794278 concentrations and stimulated with 5 M L-glutamate (EC80). Changes in intracellular Ca2+following stimulation were detected as changes in maximum relative fluorescence (RLU) using FLIPRTETRA?. IC50was determined at 4.16 nM.

产品信息

SKU号 :

APC-023_1_25_mcl

ParentSKU :

APC-023

Taxonomy Node :

Primary Antibody>Intracellular>Non-Labeled

Action :

Insert

产品名称 :

抗Kv4.2抗体

产品描述 :

Anti-KV4.2 Antibody (#APC-023) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunoprecipitation, immunocytochemistry, and immunohistochemistry applications. It has been designed to recognize KV4.2 from human, rat, and mouse samples.

Short Description :

A Rabbit Polyclonal Antibody to KV4.2 Channel

Negative Control :

BLP-PC023

同义词 :

KV4.2, Voltage-gated potassium channel subfamily D member 2, KCND2, Shal1, RK5

靶标名 :

KV4.2 Channel

Primary Category (Old) :

Ion Channels > K+ Channels > Voltage-Gated K+ Channels > Antibodies to KV Channels

标记/共轭标签 :

未共轭

应用 :

免疫细胞化学, IF, 免疫组化, 免疫沉淀, 免疫印迹

宿主 :

兔

克隆性 :

多克隆

抗体亚型 :

兔IgG

基因符号 :

KCND2

反应物种 :

人类(试验);小鼠(试验);大鼠(试验)

同源 :

Mouse, human - 15/16 amino acid residues identical.

靶标/背景信息 :

KV4.2 is a voltage-dependent K+ channel that belongs to the Shal channel subfamily and includes two other members: KV4.1 and KV4.3.1 KV4.2 possesses the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. As with other members of the voltage-gated K+ channel superfamily, the functional channel is a tetramer that can be composed of more than one member of the Shal subfamily, i.e. heterotetramers of KV4.1 and KV4.3. The KV4 channels are characterized by activation at subthreshold membrane potentials, inactivate rapidly and recover from inactivation quickly compared with other voltage-dependent K+ channels. This type of current is known as transient A-type K+ currents. For example, depolarization-activated K+ currents in rat neostriatal cholinergic interneurons are predominantly of the A-type and attributable to coexpression of KV4.2 and KV4.1 subunits.2 The biophysical properties of the KV4.2 subunit can be modified by its association with auxiliary β subunits such as the KChIP family that increase KV4.2 current densities and accelerates both the inactivation and the recovery time. KV4.2 is also highly expressed in the heart where together with KV4.3 underlie the fast inactivating and recovering cardiac transient outward current Ito.3 Several toxins from spider venoms are potent blockers (affecting the channels in the nanomolar range) of KV4.2 channels. Among these the most potent and selective are Stromatoxin-1 (#STS-350), (1.2nM), Phrixotoxin-1 (#STP-700), (5 nM), Phrixotoxin-2 (#STP-710), (34 nM) and Heteropodatoxin-2 (#STH-340), (100 nM).4

免疫原 :

合成肽

区域 :

intracellular

Loop :

Intracellular, C-terminus

序列 :

(C)SNQLQSSEDEPAFVSK, corresponding to amino acid residues 454-469 of rat KV4.2

序列文本 :

Peptide (C)SNQLQSSEDEPAFVSK, corresponding to amino acid residues 454-469 of rat KV4.2 (Accession Q63881). Intracellular, C-terminus.

Primary Size (Size+Units) :

1 X 25 mcl

浓度 :

0.6毫克/毫升

浓度 :

06毫克/毫升

缓冲液 :

磷酸盐缓冲液(PBS)

pH值 :

pH值7.4

防腐剂 :

1% BSA, 0.05% NaN3 (% of reconstituted antibody)

Additive(s) :

Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.

格式(液体/冻干) :

冻干粉末

纯化来源(杂交瘤细胞, 腹水 :

Affinity purified on immobilized antigen

储存温度 :

-20°C

UniProt数据库 :

Q63881

Top Related :

APC-017, ASC-005, APC-007, ACC-003, APC-022

储存和重组 :

Reconstitution: 1 X 25 mcl double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

包装规格 :

产品规格/规格 :

单位 :

mcl

标价美国[美元] :

425美元

更多信息或购买 :

Alomone Labs 产品网页

公司信息

Alomone Labs

Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201

info@alomone.com

http://www.alomone.com

972-2-587-2202

公司总部: 以色列

Alomone Labs公司成立于1989年，在离子通道、GPCR及神经信号通路研究等领域占据全球领先地位。