产品简要
公司名称 :
Alomone Labs
产品类型 :
抗体
产品名称 :
抗Kir2.1/KCNJ2抗体
目录 :
APC-026
规格 :
1 X 25 mcl
价格 :
425美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
Alomone Labs 产品网页
文章摘录数: 14
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 1:400; 图 4a
Vila A, Shihabeddin E, Zhang Z, Santhanam A, Ribelayga C, O BRIEN J. Synaptic Scaffolds, Ion Channels and Polyamines in Mouse Photoreceptor Synapses: Anatomy of a Signaling Complex. Front Cell Neurosci. 2021;15:667046 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5s1a
Lieberman O, Frier M, McGuirt A, Griffey C, Rafikian E, Yang M, et al. Cell-type-specific regulation of neuronal intrinsic excitability by macroautophagy. elife. 2020;9: pubmed 出版商
Simon Chica A, Fern xe1 ndez M, W xfc lfers E, Lother A, Hilgendorf I, Seemann G, et al. Novel insights into the electrophysiology of murine cardiac macrophages: relevance of voltage-gated potassium channels. Cardiovasc Res. 2022;118:798-813 pubmed 出版商
Kabakov A, Sengun E, Lu Y, Roder K, Bronk P, Baggett B, et al. Three-Week-Old Rabbit Ventricular Cardiomyocytes as a Novel System to Study Cardiac Excitation and EC Coupling. Front Physiol. 2021;12:672360 pubmed 出版商
Liu M, Liu H, Parthiban P, Kang G, Shi G, Feng F, et al. Inhibition of the unfolded protein response reduces arrhythmia risk after myocardial infarction. J Clin Invest. 2021;131: pubmed 出版商
Sengupta S, Rothenberg K, Li H, Hoffman B, Bursac N. Altering integrin engagement regulates membrane localization of Kir2.1 channels. J Cell Sci. 2019;132: pubmed 出版商
Fischer R, Roux A, Wareham L, Sappington R. Pressure-dependent modulation of inward-rectifying K+ channels: implications for cation homeostasis and K+ dynamics in glaucoma. Am J Physiol Cell Physiol. 2019;317:C375-C389 pubmed 出版商
Guan Y, Gao X, Tang Q, Huang L, Gao S, Yu S, et al. Nucleoporin 107 facilitates the nuclear export of Scn5a mRNA to regulate cardiac bioelectricity. J Cell Mol Med. 2019;23:1448-1457 pubmed 出版商
Xia P, Li L, Qi R, Shi J, Ju W, Chen M. Electrical and histological remodeling of the pulmonary vein in 2K1C hypertensive rats: Indication of initiation and maintenance of atrial fibrillation. Anatol J Cardiol. 2018;19:169-175 pubmed 出版商
Sun Y, Timofeyev V, Dennis A, Bektik E, Wan X, Laurita K, et al. A Singular Role of IK1 Promoting the Development of Cardiac Automaticity during Cardiomyocyte Differentiation by IK1 -Induced Activation of Pacemaker Current. Stem Cell Rev. 2017;13:631-643 pubmed 出版商
Caballero R, Utrilla R, Amorós I, Matamoros M, Pérez Hernández M, Tinaquero D, et al. Tbx20 controls the expression of the KCNH2 gene and of hERG channels. Proc Natl Acad Sci U S A. 2017;114:E416-E425 pubmed 出版商
Rubi L, Koenig X, Kubista H, Todt H, Hilber K. Decreased inward rectifier potassium current IK1 in dystrophin-deficient ventricular cardiomyocytes. Channels (Austin). 2017;11:101-108 pubmed 出版商
Li Q, Cui P, Miao Y, Gao F, Li X, Qian W, et al. Activation of group I metabotropic glutamate receptors regulates the excitability of rat retinal ganglion cells by suppressing Kir and I h. Brain Struct Funct. 2017;222:813-830 pubmed 出版商
Murata Y, Yasaka T, Takano M, Ishihara K. Neuronal and glial expression of inward rectifier potassium channel subunits Kir2.x in rat dorsal root ganglion and spinal cord. Neurosci Lett. 2016;617:59-65 pubmed 出版商
图像
图像 1 :
Alomone Labs APC-026 图像 1
Western blot analysis of rat heart (lanes 1 and 3) and rat brain (lanes 2 and 4) membranes: - 1,2. Anti-Kir2.1/KCNJ2 Antibody (#APC-026), (1:200).3,4. Anti-Kir2.1/KCNJ2 Antibody, preincubated with Kir2.1/KCNJ2 Blocking Peptide (#BLP-PC026).
图像 2 :
Alomone Labs APC-026 图像 2
Peptide (C)NGVPESTSTDTPPDIDLHN corresponding to amino acid residues 392-410 of human Kir2.1 (AccessionP48049). Intracellular C-terminus.
图像 3 :
Alomone Labs APC-026 图像 3
Peptide (C)NGVPESTSTDTPPDIDLHN corresponding to amino acid residues 392-410 of human Kir2.1 (AccessionP48049). Intracellular C-terminal part.
产品信息
SKU号 :
APC-026_1_25_mcl
ParentSKU :
APC-026
Taxonomy Node :
Primary Antibody>Intracellular>Non-Labeled
Action :
Insert
产品名称 :
抗Kir2.1/KCNJ2抗体
产品描述 :
Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of human Kir2.1 channel. Anti-Kir2.1/KCNJ2 Antibody (#APC-026) can be used in western blot, immunoprecipitation, immunocytochemistry, immunohistochemistry, and flow cytometry applications. It has been designed to recognize Kir2.1 from human, rat, and mouse samples.
Short Description :
A Rabbit Polyclonal Antibody to Kir2.1 (KCNJ2) Channel
Negative Control :
BLP-PC026
同义词 :
Kir2.1(KCNJ2), 内向整流钾离子通道2, IRK1, HIRK1, LQT7, SQT3
靶标名 :
Kir2.1 (KCNJ2) Channel
Primary Category (Old) :
Ion Channels > K+ Channels > Inward Rectifier K+ Channels > Antibodies to Kir Channels
标记/共轭标签 :
未共轭
应用 :
免疫细胞化学, IF, IFC, 免疫组化, 免疫沉淀, 免疫印迹
宿主 :
兔
克隆性 :
多克隆
抗体亚型 :
兔IgG
基因符号 :
KCNJ2
反应物种 :
人类(试验);小鼠(试验);大鼠(试验)
同源 :
Rabbit, bovine, pig, guinea pig - identical; rat, mouse - 17/19 amino acid residues identical; chicken - 15/19 amino acid residues identical.
靶标/背景信息 :
Kir2.1 is a member of the family of inward rectifying K+ channels. The family includes 15 members that are structurally and functionally different from the voltage-dependent K+ channels.1  The family’s topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels the functional unit for the Kir channels is composed of four subunits that can assemble as either homo- or heterotetramers. Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis. Kir2.1 is a member of the Kir2.x subfamily that includes four members (Kir2.1- Kir2.4) that are characterized by strong inward rectification and high constitutive activity. Kir2.1 is expressed in a variety of tissues including the heart, brain, vascular smooth muscle cells and skeletal muscles. In the heart, Kir2.1 is a molecular component of the IK1 current that is responsible for setting the resting membrane potential, preventing membrane hyperpolarization due to Na+ pump activity, influencing propagation velocity, altering the electrical space constant, and promoting late phase repolarization.2 In fact, mutations in Kir2.1 channels have been linked to a form of long QT syndrome (LQT7) known as Andersen's syndrome that is characterized by cardiac arrhythmias, periodic paralysis, and dysmorphic features.3
免疫原 :
合成肽
区域 :
intracellular
Loop :
Intracellular, C-terminal domain
序列 :
(C)NGVPESTSTDTPPDIDLHN, corresponding to amino acid residues 392-410 of human Kir2.1
序列文本 :
Peptide (C)NGVPESTSTDTPPDIDLHN, corresponding to amino acid residues 392-410 of human Kir2.1 (Accession P48049). Intracellular, C-terminal part.
Primary Size (Size+Units) :
1 X 25 mcl
浓度 :
0.6毫克/毫升
浓度 :
06毫克/毫升
缓冲液 :
磷酸盐缓冲液(PBS)
pH值 :
pH值7.4
防腐剂 :
1% BSA, 0.05% NaN3 (% of reconstituted antibody)
Additive(s) :
Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
格式(液体/冻干) :
冻干粉末
纯化来源(杂交瘤细胞, 腹水 :
Affinity purified on immobilized antigen
储存温度 :
-20°C
UniProt数据库 :
P48049
Top Related :
ASC-005, ACC-003, APC-042, APC-159, APC-032
储存和重组 :
Reconstitution: 1 X 25 mcl double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 × g 5 min).
包装规格 :
1
产品规格/规格 :
25
单位 :
mcl
标价美国[美元] :
425美元
更多信息或购买 :
Alomone Labs 产品网页
公司信息
Alomone Labs
Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201
info@alomone.com
http://www.alomone.com
972-2-587-2202
公司总部: 以色列
Alomone Labs公司成立于1989年，在离子通道、GPCR及神经信号通路研究等领域占据全球领先地位。