抗体

抗Kir2.3(KCNJ4)抗体

APC-032

1 X 50 mcl

530美元

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学

APC-032

Primary Antibody>Intracellular>Non-Labeled

Insert

抗Kir2.3(KCNJ4)抗体

Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of the rat Kir2.3 channel. Anti-Kir2.3 (KCNJ4) Antibody (#APC-032) can be used in western blot, immunocytochemistry, and immunohistochemistry applications. It has been designed to recognize Kir2.3 from human, rat, and mouse samples.

A Rabbit Polyclonal Antibody to Kir2.3 (KCNJ4) Channel

BLP-PC032

Kir2.3(KCNJ4), 内向整流钾离子通道4, BIR11, IRK3, HIRK2, HRK1

Kir2.3 (KCNJ4) Channel

Ion Channels > K+ Channels > Inward Rectifier K+ Channels > Antibodies to Kir Channels

未共轭

免疫细胞化学, IF, 免疫组化, 免疫印迹

兔

多克隆

兔IgG

KCNJ4

人类(试验);小鼠(试验);大鼠(试验)

Mouse - identical; guinea pig - 19/20 amino acid residues identical; hamster, human, Xenopus - 18/20 amino acid residues identical.

Kir2.3 is a member of the family of inward rectifying K+ channels. The family includes 15 members that are structurally and functionally different from the voltage-dependent K+ channels. The family’s topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels the functional unit for the Kir channels is composed of four subunit that can assembly as either homo or heterotetramers. Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis. Kir2.3 is a member of the Kir2.x subfamily that includes four members (Kir2.1- Kir2.4) that are characterized by strong inward rectification and high constitutive activity. Kir2.3 is expressed in a variety of tissues including heart and brain. 2 In the heart, Kir2.3 forms heteromers with Kir2.1 and underlay the IK1 current (at least in some species) that is responsible for setting the resting membrane potential, preventing membrane hyperpolarization due to Na+ pump activity, influencing propagation velocity, altering the electrical space constant, and promoting late phase repolarization.1,2

合成肽

intracellular

Intracellular, C-terminal domain

(C)EFGS HLDLE RMQAA TLPLD N, corresponding to amino acid residues 418-437 of rat Kir2.3

Peptide (C)EFGS HLDLE RMQAA TLPLD N, corresponding to amino acid residues 418-437 of rat Kir2.3 (Accession P52190). Intracellular, C-terminal part.

1 X 50 mcl

0.8毫克/毫升

08毫克/毫升

磷酸盐缓冲液(PBS)

pH值7.4

1% BSA, 0.05% NaN3 (% of reconstituted antibody)

Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.

冻干粉末

Affinity purified on immobilized antigen

-20°C

P52190

APC-026, ACC-003, APC-042, APC-005, APC-058

Reconstitution: 1 X 50 mcl double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 × g 5 min).

1

50

mcl

530美元