抗Kir4.1(KCNJ10)抗体 | Alomone Labs APC-035 产品信息

产品简要

公司名称 :

Alomone Labs

产品类型 :

抗体

产品名称 :

抗Kir4.1(KCNJ10)抗体

APC-035

规格 :

1 X 25 mcl

价格 :

425美元

克隆性 :

多克隆

宿主 :

domestic rabbit

共轭标签 :

未共轭

反应物种 :

人类, 小鼠, 大鼠

应用 :

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片

更多信息或购买 :

Alomone Labs 产品网页

文章摘录数: 54

出版应用/物种/样本/稀释	参考文献
免疫细胞化学; 人类; 1:1000; 图 6d	Umans R, Pollock C, Mills W, Clark K, Pan Y, Sontheimer H. Using Zebrafish to Elucidate Glial-Vascular Interactions During CNS Development. Front Cell Dev Biol. 2021;9:654338 pubmed 出版商
免疫组化; 小鼠; 1:1000; 图 1a	Poli G, Hasan S, Belia S, Cenciarini M, Tucker S, Imbrici P, et al. Kcnj16 (Kir5.1) Gene Ablation Causes Subfertility and Increases the Prevalence of Morphologically Abnormal Spermatozoa. Int J Mol Sci. 2021;22: pubmed 出版商
免疫组化-冰冻切片; 小鼠; 1:200; 图 7s1a	Benz F, Wichitnaowarat V, Lehmann M, Germano R, Mihova D, Macas J, et al. Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice. elife. 2019;8: pubmed 出版商
免疫组化; 小鼠; 1:300; 图 5	Ingham N, Carlisle F, Pearson S, Lewis M, Buniello A, Chen J, et al. S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse. Sci Rep. 2016;6:28964 pubmed 出版商
免疫组化-石蜡切片; 人类; 4 ug/ml; 图 3	Koeppen A, Ramirez R, Becker A, Mazurkiewicz J. Dorsal root ganglia in Friedreich ataxia: satellite cell proliferation and inflammation. Acta Neuropathol Commun. 2016;4:46 pubmed 出版商
免疫组化-冰冻切片; 人类; 1:500; 图 7	Liu W, Edin F, Blom H, Magnusson P, Schrott Fischer A, Glueckert R, et al. Super-resolution structured illumination fluorescence microscopy of the lateral wall of the cochlea: the Connexin26/30 proteins are separately expressed in man. Cell Tissue Res. 2016;365:13-27 pubmed 出版商
免疫组化-冰冻切片; 大鼠; 1:600; 图 4a 免疫印迹; 大鼠; 1:800; 图 2a	Najafi E, Stoodley M, Bilston L, Hemley S. Inwardly rectifying potassium channel 4.1 expression in post-traumatic syringomyelia. Neuroscience. 2016;317:23-35 pubmed 出版商
	Hyndman K, Isaeva E, Palygin O, Mendoza L, Rodan A, Staruschenko A, et al. Role of collecting duct principal cell NOS1β in sodium and potassium homeostasis. Physiol Rep. 2021;9:e15080 pubmed 出版商
	Muto Y, Wilson P, Ledru N, Wu H, Dimke H, Waikar S, et al. Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney. Nat Commun. 2021;12:2190 pubmed 出版商
	Smith K, Murphy P, Jagger D. Divergent membrane properties of mouse cochlear glial cells around hearing onset. J Neurosci Res. 2021;99:679-698 pubmed 出版商
	Götz S, Bribian A, López Mascaraque L, Gotz M, Grothe B, Kunz L. Heterogeneity of astrocytes: Electrophysiological properties of juxtavascular astrocytes before and after brain injury. Glia. 2021;69:346-361 pubmed 出版商
	Padmashri R, Ren B, Oldham B, Jung Y, Gough R, Dunaevsky A. Modeling human-specific interlaminar astrocytes in the mouse cerebral cortex. J Comp Neurol. 2021;529:802-810 pubmed 出版商
	Takano T, Wallace J, Baldwin K, Purkey A, Uezu A, Courtland J, et al. Chemico-genetic discovery of astrocytic control of inhibition in vivo. Nature. 2020;588:296-302 pubmed 出版商
	Bucher F, Aguilar E, Marra K, Rapp J, Arnold J, Diaz Aguilar S, et al. CNTF Prevents Development of Outer Retinal Neovascularization Through Upregulation of CxCl10. Invest Ophthalmol Vis Sci. 2020;61:20 pubmed 出版商
	Sheng L, Stewart T, Yang D, Thorland E, Soltys D, Aro P, et al. Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson's disease pathogenesis. Acta Neuropathol Commun. 2020;8:102 pubmed 出版商
	Wu P, Su X, Gao Z, Zhang D, Duan X, Xiao Y, et al. Renal Tubule Nedd4-2 Deficiency Stimulates Kir4.1/Kir5.1 and Thiazide-Sensitive NaCl Cotransporter in Distal Convoluted Tubule. J Am Soc Nephrol. 2020;31:1226-1242 pubmed 出版商
	Limbad C, Oron T, Alimirah F, Davalos A, Tracy T, Gan L, et al. Astrocyte senescence promotes glutamate toxicity in cortical neurons. PLoS ONE. 2020;15:e0227887 pubmed 出版商
	Tian C, Johnson K. TBX1 is required for normal stria vascularis and semicircular canal development. Dev Biol. 2020;457:91-103 pubmed 出版商
	Korrapati S, Taukulis I, Olszewski R, Pyle M, Gu S, Singh R, et al. Single Cell and Single Nucleus RNA-Seq Reveal Cellular Heterogeneity and Homeostatic Regulatory Networks in Adult Mouse Stria Vascularis. Front Mol Neurosci. 2019;12:316 pubmed 出版商
	Miwa T, Minoda R, Ishikawa Y, Kajii T, Orita Y, Ohyama T. Role of Dach1 revealed using a novel inner ear-specific Dach1-knockdown mouse model. Biol Open. 2019;8: pubmed 出版商
	Liu T, Li G, Noble K, Li Y, Barth J, Schulte B, et al. Age-dependent alterations of Kir4.1 expression in neural crest-derived cells of the mouse and human cochlea. Neurobiol Aging. 2019;80:210-222 pubmed 出版商
	Fischer R, Roux A, Wareham L, Sappington R. Pressure-dependent modulation of inward-rectifying K+ channels: implications for cation homeostasis and K+ dynamics in glaucoma. Am J Physiol Cell Physiol. 2019;317:C375-C389 pubmed 出版商
	Luo Q, Xiao Y, Alex A, Cummins T, Bhatwadekar A. The Diurnal Rhythm of Insulin Receptor Substrate-1 (IRS-1) and Kir4.1 in Diabetes: Implications for a Clock Gene Bmal1. Invest Ophthalmol Vis Sci. 2019;60:1928-1936 pubmed 出版商
	Kinboshi M, Shimizu S, Mashimo T, Serikawa T, Ito H, Ikeda A, et al. Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats. Int J Mol Sci. 2019;20: pubmed 出版商
	Rao S, Katoozi S, Skauli N, Froehner S, Ottersen O, Adams M, et al. Targeted deletion of β1-syntrophin causes a loss of Kir 4.1 from Müller cell endfeet in mouse retina. Glia. 2019;67:1138-1149 pubmed 出版商
	Shandra O, Winemiller A, Heithoff B, Muñoz Ballester C, George K, Benko M, et al. Repetitive Diffuse Mild Traumatic Brain Injury Causes an Atypical Astrocyte Response and Spontaneous Recurrent Seizures. J Neurosci. 2019;39:1944-1963 pubmed 出版商
	Wood T, Barry J, Yang Z, Cepeda C, Levine M, Gray M. Mutant huntingtin reduction in astrocytes slows disease progression in the BACHD conditional Huntington's disease mouse model. Hum Mol Genet. 2019;28:487-500 pubmed 出版商
	Skowrońska K, Obara Michlewska M, Czarnecka A, Dabrowska K, Zielinska M, Albrecht J. Persistent Overexposure to N-Methyl-D-Aspartate (NMDA) Calcium-Dependently Downregulates Glutamine Synthetase, Aquaporin 4, and Kir4.1 Channel in Mouse Cortical Astrocytes. Neurotox Res. 2019;35:271-280 pubmed 出版商
	Cerrato V, Parmigiani E, Figueres Oñate M, Betizeau M, Aprato J, Nanavaty I, et al. Multiple origins and modularity in the spatiotemporal emergence of cerebellar astrocyte heterogeneity. PLoS Biol. 2018;16:e2005513 pubmed 出版商
	Schirmer L, Mobius W, Zhao C, Cruz Herranz A, Ben Haim L, Cordano C, et al. Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity. elife. 2018;7: pubmed 出版商
	Yu X, Taylor A, Nagai J, GOLSHANI P, Evans C, Coppola G, et al. Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior. Neuron. 2018;99:1170-1187.e9 pubmed 出版商
	Mukai T, Kinboshi M, Nagao Y, Shimizu S, Ono A, Sakagami Y, et al. Antiepileptic Drugs Elevate Astrocytic Kir4.1 Expression in the Rat Limbic Region. Front Pharmacol. 2018;9:845 pubmed 出版商
	Malik S, Lambert E, Zhang J, Wang T, Clark H, Cypress M, et al. Potassium conservation is impaired in mice with reduced renal expression of Kir4.1. Am J Physiol Renal Physiol. 2018;315:F1271-F1282 pubmed 出版商
	Zhang D, Gao Z, Vio C, Xiao Y, Wu P, Zhang H, et al. Bradykinin Stimulates Renal Na+ and K+ Excretion by Inhibiting the K+ Channel (Kir4.1) in the Distal Convoluted Tubule. Hypertension. 2018;72:361-369 pubmed 出版商
	Wang M, Su X, Wu P, Gao Z, Wang W, Staub O, et al. Kir5.1 regulates Nedd4-2-mediated ubiquitination of Kir4.1 in distal nephron. Am J Physiol Renal Physiol. 2018;315:F986-F996 pubmed 出版商
	Kelley K, Ben Haim L, Schirmer L, Tyzack G, Tolman M, Miller J, et al. Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength. Neuron. 2018;98:306-319.e7 pubmed 出版商
	Larson V, Mironova Y, Vanderpool K, Waisman A, Rash J, Agarwal A, et al. Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility. elife. 2018;7: pubmed 出版商
	Sharlin D, Ng L, Verrey F, Visser T, Liu Y, Olszewski R, et al. Deafness and loss of cochlear hair cells in the absence of thyroid hormone transporters Slc16a2 (Mct8) and Slc16a10 (Mct10). Sci Rep. 2018;8:4403 pubmed 出版商
	Kitaura H, Shirozu H, Masuda H, Fukuda M, Fujii Y, Kakita A. Pathophysiological Characteristics Associated With Epileptogenesis in Human Hippocampal Sclerosis. EBioMedicine. 2018;29:38-46 pubmed 出版商
	Thompson K, Chen J, Luo Q, Xiao Y, Cummins T, Bhatwadekar A. Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells. PLoS ONE. 2018;13:e0193280 pubmed 出版商
	Cui Y, Yang Y, Ni Z, Dong Y, Cai G, Foncelle A, et al. Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression. Nature. 2018;554:323-327 pubmed 出版商
	Sato M, Higuchi T, Nin F, Ogata G, Sawamura S, Yoshida T, et al. Hearing Loss Controlled by Optogenetic Stimulation of Nonexcitable Nonglial Cells in the Cochlea of the Inner Ear. Front Mol Neurosci. 2017;10:300 pubmed 出版商
	Liu W, Schrott Fischer A, Glueckert R, Benav H, Rask Andersen H. The Human "Cochlear Battery" - Claudin-11 Barrier and Ion Transport Proteins in the Lateral Wall of the Cochlea. Front Mol Neurosci. 2017;10:239 pubmed 出版商
	Chai H, Diaz Castro B, Shigetomi E, Monte E, Octeau J, Yu X, et al. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron. 2017;95:531-549.e9 pubmed 出版商
	Silva J, Lopes A, Talbot J, Cecílio N, Rossato M, Silva R, et al. Neuroimmune-Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia. J Neurosci. 2017;37:6408-6422 pubmed 出版商
	Marangoni D, Yong Z, Kjellstrom S, Vijayasarathy C, A Sieving P, Bush R. Rearing Light Intensity Affects Inner Retinal Pathology in a Mouse Model of X-Linked Retinoschisis but Does Not Alter Gene Therapy Outcome. Invest Ophthalmol Vis Sci. 2017;58:1656-1664 pubmed 出版商
	Puissant M, Mouradian G, Liu P, Hodges M. Identifying Candidate Genes that Underlie Cellular pH Sensitivity in Serotonin Neurons Using Transcriptomics: A Potential Role for Kir5.1 Channels. Front Cell Neurosci. 2017;11:34 pubmed 出版商
	Blankenstein K, Borschewski A, Labes R, Paliege A, Boldt C, McCormick J, et al. Calcineurin inhibitor cyclosporine A activates renal Na-K-Cl cotransporters via local and systemic mechanisms. Am J Physiol Renal Physiol. 2017;312:F489-F501 pubmed 出版商
	Shibata S, Miwa T, Wu H, Levitt P, Ohyama T. Hepatocyte Growth Factor-c-MET Signaling Mediates the Development of Nonsensory Structures of the Mammalian Cochlea and Hearing. J Neurosci. 2016;36:8200-9 pubmed 出版商
	Lopez I, Ishiyama G, Hosokawa S, Hosokawa K, Acuna D, Linthicum F, et al. Immunohistochemical techniques for the human inner ear. Histochem Cell Biol. 2016;146:367-87 pubmed 出版商
	Vacca O, Charles Messance H, El Mathari B, Sene A, Barbe P, Fouquet S, et al. AAV-mediated gene therapy in Dystrophin-Dp71 deficient mouse leads to blood-retinal barrier restoration and oedema reabsorption. Hum Mol Genet. 2016;25:3070-3079 pubmed
	Battefeld A, Klooster J, Kole M. Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity. Nat Commun. 2016;7:11298 pubmed 出版商
	Zhang C, Su X, Bellner L, Lin D. Caveolin-1 regulates corneal wound healing by modulating Kir4.1 activity. Am J Physiol Cell Physiol. 2016;310:C993-C1000 pubmed 出版商
	Brasko C, Hawkins V, De La Rocha I, Butt A. Expression of Kir4.1 and Kir5.1 inwardly rectifying potassium channels in oligodendrocytes, the myelinating cells of the CNS. Brain Struct Funct. 2017;222:41-59 pubmed 出版商

图像

图像 1 :

Western blot analysis of rat brain membranes: - 1. Anti-Kir4.1 (KCNJ10) Antibody (#APC-035), (1:400).2. Anti-Kir4.1 (KCNJ10) Antibody, preincubated with Kir4.1/KCNJ10 Blocking Peptide (#BLP-PC035).

图像 2 :

Peptide (C)KLEESLREQAEKEGSALSVR corresponding to amino acid residues 356-375 of rat Kir4.1 (AccessionP49655). Intracellular C-terminus.

产品信息

SKU号 :

APC-035_1_25_mcl

ParentSKU :

APC-035

Taxonomy Node :

Primary Antibody>Intracellular>Non-Labeled

Action :

Insert

产品名称 :

抗Kir4.1(KCNJ10)抗体

产品描述 :

Anti-Kir4.1 (KCNJ10) Antibody (#APC-035) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunoprecipitation, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize Kir4.1 potassium channel from rat, mouse, and human samples.

Short Description :

A Rabbit Polyclonal Antibody to Kir4.1 (KCNJ10) Channel

Negative Control :

BLP-PC035

同义词 :

Kir4.1, ATP-sensitive inward rectifier potassium channel 10, KAB-2, BIR10, BIRK1, Kir1.2, Potassium channel Inwardly rectifying subfamily J member 10

靶标名 :

Kir4.1 (KCNJ10) Channel

Primary Category (Old) :

Ion Channels > K+ Channels > Inward Rectifier K+ Channels > Antibodies to Kir Channels

标记/共轭标签 :

未共轭

应用 :

免疫细胞化学, IF, 免疫组化, 免疫沉淀, 免疫印迹

宿主 :

兔

克隆性 :

多克隆

抗体亚型 :

兔IgG

基因符号 :

KCNJ10

反应物种 :

人类(试验);小鼠(试验);大鼠(试验)

同源 :

Human, mouse - identical.

靶标/背景信息 :

Kir4.1 is a member of the inward rectifying K+ channel family. The family includes 15 members that are structurally and functionally different from the voltage-dependent K+ channels. The family’s topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels the functional unit for the Kir channels is composed of four subunit that can assembly as either homo or heteromers. Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis. Kir4.1 is a member of the Kir4 subfamily that includes one other member: Kir4.2. Kir4.1 can co-assemble with Kir4.2 but also with other Kir channels such as Kir2.1 and Kir5.1. The Kir4 subfamily has been classified as weak rectifiers with intermediate conductance. Kir4.1, encoded by KCNJ10, is mainly expressed in brain, specifically in glia cells, but also in retina, ear and kidney.1,2 It has been proposed that Kir4.1 has an essential role in glial K+ buffering, a process that re-uptakes the K+ released during neuronal activity into the intracellular interstitial space. Loss of Kir4.1 causes retinal defects and loss of endochoclear potential.3

免疫原 :

合成肽

区域 :

intracellular

Loop :

Intracellular, C-terminus

序列 :

(C)KLEE SLREQ AEKEG SALSV R, corresponding to amino acid residues 356-375 of rat Kir4.1

序列文本 :

Peptide (C)KLEE SLREQ AEKEG SALSV R, corresponding to amino acid residues 356-375 of rat Kir4.1 (Accession P49655). Intracellular, C-terminus.

Primary Size (Size+Units) :

1 X 25 mcl

浓度 :

0.8毫克/毫升

浓度 :

08毫克/毫升

缓冲液 :

磷酸盐缓冲液(PBS)

pH值 :

pH值7.4

防腐剂 :

1% BSA, 0.05% NaN3 (% of reconstituted antibody)

Additive(s) :

Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.

格式(液体/冻干) :

冻干粉末

纯化来源(杂交瘤细胞, 腹水 :

Affinity purified on immobilized antigen

储存温度 :

-20°C

UniProt数据库 :

P49655

Top Related :

AQP-004, APC-165, APC-123, AGP-012, AGC-022

储存和重组 :

Reconstitution: 1 X 25 mcl double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

包装规格 :

产品规格/规格 :

单位 :

mcl

标价美国[美元] :

425美元

更多信息或购买 :

Alomone Labs 产品网页

公司信息

Alomone Labs

Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201

info@alomone.com

http://www.alomone.com

972-2-587-2202

公司总部: 以色列

Alomone Labs公司成立于1989年，在离子通道、GPCR及神经信号通路研究等领域占据全球领先地位。