产品简要
公司名称 :
Alomone Labs
产品类型 :
抗体
产品名称 :
抗KCNQ4抗体
目录 :
APC-164
规格 :
1 X 25 mcl
价格 :
425美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
更多信息或购买 :
文章摘录数: 5
参考文献
Perez Flores M, Lee J, Park S, Zhang X, Sihn C, Ledford H, et al. Cooperativity of Kv7.4 channels confers ultrafast electromechanical sensitivity and emergent properties in cochlear outer hair cells. Sci Adv. 2020;6:eaba1104 pubmed 出版商
Inagaki A, Hayashi M, Andharia N, Matsuda H. Involvement of butyrate in electrogenic K+ secretion in rat rectal colon. Pflugers Arch. 2019;471:313-327 pubmed 出版商
Paz R, Tubert C, Stahl A, Díaz A, Etchenique R, Murer M, et al. Inhibition of striatal cholinergic interneuron activity by the Kv7 opener retigabine and the nonsteroidal anti-inflammatory drug diclofenac. Neuropharmacology. 2018;137:309-321 pubmed 出版商
Li L, Sun H, Ding J, Niu C, Su M, Zhang L, et al. Selective targeting of M-type potassium Kv 7.4 channels demonstrates their key role in the regulation of dopaminergic neuronal excitability and depression-like behaviour. Br J Pharmacol. 2017;174:4277-4294 pubmed 出版商
Goodwill A, Fu L, Noblet J, Casalini E, Sassoon D, Berwick Z, et al. KV7 channels contribute to paracrine, but not metabolic or ischemic, regulation of coronary vascular reactivity in swine. Am J Physiol Heart Circ Physiol. 2016;310:H693-704 pubmed 出版商
图像
图像 1 :
Alomone Labs APC-164 图像 1
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain membranes: - 1,2. Anti-KCNQ4 Antibody (#APC-164), (1:200).3,4. Anti-KCNQ4 Antibody, preincubated with KCNQ4 Blocking Peptide (#BLP-PC164).
图像 2 :
Alomone Labs APC-164 图像 2
Expression of KCNQ4 (KV7.4) in rat lateral dorsal raphe nucleus - Immunohistochemical staining of perfusion-fixed frozen rat brain sections using Anti-KCNQ4 Antibody (#APC-164), (1:400), followed by biotin-labeled anti-rabbit antibody and streptavidin-ATTO Fluor-594 (red). Staining appears in soma of neuronal profiles (arrows). Nuclei are stained with DAPI (blue).
产品信息
SKU号 :
APC-164_1_25_mcl
ParentSKU :
APC-164
Taxonomy Node :
Primary Antibody>Intracellular>Non-Labeled
Action :
Insert
产品名称 :
抗KCNQ4抗体
产品描述 :
Anti-KCNQ4 Antibody (#APC-164) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize KV7.4 from rat, human, and mouse samples.
Short Description :
A Rabbit Polyclonal Antibody to KCNQ4 (KV7.4) Channel
Negative Control :
BLP-PC164
同义词 :
KCNQ4, KV7.4, Potassium voltage-gated channel subfamily KQT member 4, KQT-like 4, KvLQT4, DFNA2
靶标名 :
KCNQ4 (KV7.4) Channel
Primary Category (Old) :
Ion Channels > K+ Channels > Voltage-Gated K+ Channels > Antibodies to KV Channels
标记/共轭标签 :
未共轭
应用 :
IF, 免疫组化, 免疫印迹
宿主 :
克隆性 :
多克隆
抗体亚型 :
兔IgG
基因符号 :
KCNQ4
反应物种 :
人类(试验);小鼠(试验);大鼠(试验)
同源 :
Rat - identical; human - 12/14 amino acid residues identical.
靶标/背景信息 :
The KCNQ (KV7) family of channels consists of five members (KCNQ1, KCNQ2, KCNQ3, KCNQ4 and KCNQ5). KCNQ channels commonly display activation at voltages close to neuronal resting membrane potentials and are regulated by G-protein coupled receptor (GPCR) signaling, notably by muscarinic receptors1. The KCNQ4 (KV7.4) encodes a protein of 695 amino acid residues. The homology with other members of the KCNQ family ranges from 37 to 44% at the amino acid level. KCNQ4 protein contains six domains that span the plasma membrane, and a P-loop domain which forms the K+-selective channel pore. The fourth transmembrane domain contains the voltage sensor, which is responsible for the electrically driven conformational change that leads to channel opening. Functional channels are formed by a tetrameric assembly of KCNQ4 subunits, typically in homotetrameric form, but heterotetrameric co-assembly of different members is allowed2. KCNQ2-KCNQ5 are predominantly expressed in the peripheral and central nervous system, including hippocampal cells, cortical cells, and dorsal root ganglion3. In addition KCNQ4 is expressed in the heart and in the outer, but not in the inner, sensory hair cells of the cochlea4. It has been demonstrated that KCNQ4 mutations may be a relatively frequent cause of autosomal dominant hearing loss4.
免疫原 :
合成肽
区域 :
intracellular
Loop :
Intracellular, C-terminus
序列 :
(C)DRKTREKGDKGPSD, corresponding to amino acid residues 594-607 of mouse KCNQ4
序列文本 :
Peptide (C)DRKTREKGDKGPSD, corresponding to amino acid residues 594-607 of mouse KCNQ4 (Accession Q9JK97). Intracellular, C-terminus.
Primary Size (Size+Units) :
1 X 25 mcl
浓度 :
0.8毫克/毫升
浓度 :
08毫克/毫升
缓冲液 :
磷酸盐缓冲液(PBS)
pH值 :
pH值7.4
防腐剂 :
1% BSA, 0.05% NaN3 (% of reconstituted antibody)
Additive(s) :
Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
格式(液体/冻干) :
冻干粉末
纯化来源(杂交瘤细胞, 腹水 :
Affinity purified on immobilized antigen
储存温度 :
-20°C
UniProt数据库 :
Q9JK97
Top Related :
APC-155, APC-051, APC-050, APC-022, APC-129
储存和重组 :
Reconstitution: 1 X 25 mcl double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
包装规格 :
1
产品规格/规格 :
25
单位 :
mcl
标价美国[美元] :
425美元
更多信息或购买 :
公司信息
Alomone Labs
Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201
info@alomone.com
http://www.alomone.com
972-2-587-2202
公司总部: 以色列
Alomone Labs公司成立于1989年,在离子通道、GPCR及神经信号通路研究等领域占据全球领先地位。