抗体

抗前列腺素E受体EP4(PTGER4)抗体

APR-066

1 X 50 mcl

530美元

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

APR-066

Primary Antibody>Intracellular>Non-Labeled

Insert

抗前列腺素E受体EP4(PTGER4)抗体

Anti-Prostaglandin E Receptor EP4 (PTGER4) Antibody (#APR-066) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and indirect flow cytometry applications. It has been designed to recognize EP4 receptor from rat, mouse, and human samples.

A兔多克隆抗体类前列腺素EP4受体

BLP-PR066

前列腺素E受体EP4(PTGER4), 前列腺素E2受体EP4亚类, PGE2受体EP4亚类, 类前列腺素EP4受体

类前列腺素EP4受体

G-Protein Coupled Receptors > Prostanoid Receptors > Antibodies

未共轭

IFC, 免疫印迹

兔

多克隆

兔IgG

PTGER4

人类(试验);小鼠(试验);大鼠(试验)

Mouse, human – identical.

E-type prostanoid receptor 4 (EP4) is responsible for mediating the effects of prostaglandin E2 (PGE2), an endogenous molecule involved in several biological processes such as pain, fever, regulation of vascular tone, renal function, mucosal integrity, inflammation, angiogenesis and tumor growth. In turn, EP4 receptor is involved in anti-inflammatory, anti-thrombotic, vasoprotective effects, adverse tumor-promoting and pro-angiogenic roles1,2. EP4 mRNA expression is detected in the gastrointestinal tract, uterus, hematopoietic tissues and skin. High expression is also found in most immune cell types. The EP receptors activate various signaling pathways. EP4 is a Gs coupled receptor, which activates adenylate cyclase and activates intracellular cyclic adenylyl monophosphate (cAMP) production1,2. The EP receptors contain an aspartate in the second transmembrane domain, which is involved in receptor-ligand interaction and conserved cysteine residues in the second and third extracellular domains, which form a disulfide bonds critical for stabilizing the receptor and for ligand binding3.

合成肽

intracellular

Intracellular, C-terminus

(C)RKTVLSKAIEKIK, corresponding to amino acid residues 336-348 of rat prostanoid EP4 receptor

Peptide (C)RKTVLSKAIEKIK, corresponding to amino acid residues 336-348 of rat prostanoid EP4 receptor (Accession P43114). Intracellular, C-terminus.

1 X 50 mcl

0.8毫克/毫升

08毫克/毫升

磷酸盐缓冲液(PBS)

pH值7.4

1% BSA, 0.05% NaN3 (% of reconstituted antibody)

Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.

冻干粉末

Affinity purified on immobilized antigen

-20°C

P43114

APR-064, APR-063

Reconstitution: 1 X 50 mcl double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

1

50

mcl

530美元