产品简要
公司名称 :
Alomone Labs
产品类型 :
抗体
产品名称 :
抗水通道蛋白5抗体
目录 :
AQP-005
规格 :
1 X 25 mcl
价格 :
425美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
更多信息或购买 :
Alomone Labs 产品网页
文章摘录数: 33
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 小鼠; 图 3
Maimets M, Rocchi C, Bron R, Pringle S, Kuipers J, Giepmans B, et al. Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals. Stem Cell Reports. 2016;6:150-62 pubmed 出版商
Mo Y, Nakamura H, Tanaka T, Odani T, Perez P, Ji Y, et al. Lysosomal exocytosis of HSP70 stimulates monocytic BMP6 expression in Sjögren's syndrome. J Clin Invest. 2022;132: pubmed 出版商
Zhou B, Stueve T, Mihalakakos E, Miao L, Mullen D, Wang Y, et al. Comprehensive epigenomic profiling of human alveolar epithelial differentiation identifies key epigenetic states and transcription factor co-regulatory networks for maintenance of distal lung identity. BMC Genomics. 2021;22:906 pubmed 出版商
Kim J, Lee S, Park K. CXCR4 Regulates Temporal Differentiation via PRC1 Complex in Organogenesis of Epithelial Glands. Int J Mol Sci. 2021;22: pubmed 出版商
Peng X, Wu Y, Brouwer U, van Vliet T, Wang B, Demaria M, et al. Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche. Cell Death Dis. 2020;11:854 pubmed 出版商
Takashi Y, Tomita K, Kuwahara Y, Roudkenar M, Roushandeh A, Igarashi K, et al. Mitochondrial dysfunction promotes aquaporin expression that controls hydrogen peroxide permeability and ferroptosis. Free Radic Biol Med. 2020;161:60-70 pubmed 出版商
Weber J, Rajan S, Schremmer C, Chao Y, Krasteva Christ G, Kannler M, et al. TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema. JCI Insight. 2020;5: pubmed 出版商
Dall Aglio C, Mercati F, De Felice E, Tardella F, Kamphues J, Cappai M, et al. Influence of Different Feed Physical Forms on Mandibular Gland in Growing Pigs. Animals (Basel). 2020;10: pubmed 出版商
Kaihoko Y, Tsugami Y, Suzuki N, Suzuki T, Nishimura T, Kobayashi K. Distinct expression patterns of aquaporin 3 and 5 in ductal and alveolar epithelial cells in mouse mammary glands before and after parturition. Cell Tissue Res. 2020;380:513-526 pubmed 出版商
Kim J, Kim J, Choi M, Kim S, Kim Y, Choi J. Adipose-derived mesenchymal stem cells regenerate radioiodine-induced salivary gland damage in a murine model. Sci Rep. 2019;9:15752 pubmed 出版商
Suzuki A, Shim J, Ogata K, Yoshioka H, Iwata J. Cholesterol metabolism plays a crucial role in the regulation of autophagy for cell differentiation of granular convoluted tubules in male mouse submandibular glands. Development. 2019;146: pubmed 出版商
Thiemann R, Nelson D, Michael DiPersio C, Larsen M, LaFlamme S. Establishment of a Murine Pro-acinar Cell Line to Characterize Roles for FGF2 and α3β1 Integrins in Regulating Pro-acinar Characteristics. Sci Rep. 2019;9:10984 pubmed 出版商
Vining K, Lombaert I, Patel V, Kibbey S, Pradhan Bhatt S, Witt R, et al. Neurturin-containing laminin matrices support innervated branching epithelium from adult epithelial salispheres. Biomaterials. 2019;216:119245 pubmed 出版商
Tanaka J, Mabuchi Y, Hata K, Yasuhara R, Takamatsu K, Kujiraoka S, et al. Sox9 regulates the luminal stem/progenitor cell properties of salivary glands. Exp Cell Res. 2019;: pubmed 出版商
Shitara A, Malec L, Ebrahim S, Chen D, Bleck C, Hoffman M, et al. Cdc42 negatively regulates endocytosis during apical membrane maintenance in live animals. Mol Biol Cell. 2019;30:324-332 pubmed 出版商
Hosseini Z, Nelson D, Moskwa N, Larsen M. Generating Embryonic Salivary Gland Organoids. Curr Protoc Cell Biol. 2019;83:e76 pubmed 出版商
Tanaka J, Ogawa M, Hojo H, Kawashima Y, Mabuchi Y, Hata K, et al. Generation of orthotopically functional salivary gland from embryonic stem cells. Nat Commun. 2018;9:4216 pubmed 出版商
Song E, Min S, Oyelakin A, Smalley K, Bard J, Liao L, et al. Genetic and scRNA-seq Analysis Reveals Distinct Cell Populations that Contribute to Salivary Gland Development and Maintenance. Sci Rep. 2018;8:14043 pubmed 出版商
Shi Z, Ye W, Zhang J, Zhang F, Yu D, Yu H, et al. LipoxinA4 attenuates acute pancreatitis-associated acute lung injury by regulating AQP-5 and MMP-9 expression, anti-apoptosis and PKC/SSeCKS-mediated F-actin activation. Mol Immunol. 2018;103:78-88 pubmed 出版商
Shin H, Lee S, Hong H, Lim Y, Koh W, Lim J. Stem cell properties of human clonal salivary gland stem cells are enhanced by three-dimensional priming culture in nanofibrous microwells. Stem Cell Res Ther. 2018;9:74 pubmed 出版商
Zhou B, Flodby P, Luo J, Castillo D, Liu Y, Yu F, et al. Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. J Clin Invest. 2018;128:970-984 pubmed 出版商
Hosseini Z, Nelson D, Moskwa N, Sfakis L, Castracane J, Larsen M. FGF2-dependent mesenchyme and laminin-111 are niche factors in salivary gland organoids. J Cell Sci. 2018;131: pubmed 出版商
Farrell H, Bruce K, Lawler C, Oliveira M, Cardin R, Davis Poynter N, et al. Murine Cytomegalovirus Spreads by Dendritic Cell Recirculation. MBio. 2017;8: pubmed 出版商
Kida H, Takahashi T, Nakamura Y, Kinoshita T, Hara M, Okamoto M, et al. Pathogenesis of Lethal Aspiration Pneumonia in Mecp2-null Mouse Model for Rett Syndrome. Sci Rep. 2017;7:12032 pubmed 出版商
Sakai M, Matsushita T, Hoshino R, Ono H, Ikai K, Sakai T. Identification of the protective mechanisms of Lactoferrin in the irradiated salivary gland. Sci Rep. 2017;7:9753 pubmed 出版商
Bärnthaler T, Maric J, Platzer W, Konya V, Theiler A, Hasenöhrl C, et al. The Role of PGE2 in Alveolar Epithelial and Lung Microvascular Endothelial Crosstalk. Sci Rep. 2017;7:7923 pubmed 出版商
Zeng M, Szymczak M, Ahuja M, Zheng C, Yin H, Swaim W, et al. Restoration of CFTR Activity in Ducts Rescues Acinar Cell Function and Reduces Inflammation in Pancreatic and Salivary Glands of Mice. Gastroenterology. 2017;153:1148-1159 pubmed 出版商
Flodby P, Li C, Liu Y, Wang H, Rieger M, Minoo P, et al. Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation. Sci Rep. 2017;7:3473 pubmed 出版商
Rossi L, Nicoletti M, Carmosino M, Mastrofrancesco L, Di Franco A, Indrio F, et al. Urinary Excretion of Kidney Aquaporins as Possible Diagnostic Biomarker of Diabetic Nephropathy. J Diabetes Res. 2017;2017:4360357 pubmed 出版商
Choi J, Shin H, An H, Kim Y, Lim J. Radioprotective effects of Keratinocyte Growth Factor-1 against irradiation-induced salivary gland hypofunction. Oncotarget. 2017;8:13496-13508 pubmed 出版商
Marconett C, Zhou B, Sunohara M, Pouldar T, Wang H, Liu Y, et al. Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes. Am J Respir Cell Mol Biol. 2017;56:310-321 pubmed 出版商
Joo E, Lombaert I, Yamada K. Hyperacetylation of Microtubules in Mesenchymal Cells Increases Cytokeratin 14-Positive Epithelial Progenitors in Developing Salivary Glands. J Dent Res. 2016;95:1518-1527 pubmed
Liebler J, Marconett C, Juul N, Wang H, Liu Y, Flodby P, et al. Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung. Am J Physiol Lung Cell Mol Physiol. 2016;310:L114-20 pubmed 出版商
图像
图像 1 :
Alomone Labs AQP-005 图像 1
Western blot analysis of mouse salivary gland (1 and 3) and rat lung (2 and 4): - 1,2. Anti-Aquaporin 5 Antibody (#AQP-005), (1:200).3,4. Anti-Aquaporin 5 Antibody, preincubated with Aquaporin 5 Blocking Peptide (#BLP-QP005).
图像 2 :
Alomone Labs AQP-005 图像 2
Expression of AQP5 in rat lung - Immunohistochemical staining of rat lung sections using Anti-Aquaporin 5 Antibody (#AQP-005), (left panel). The strong staining in the alveoli (red brown) is consistent with type 1 pneumocytes (arrows). Counterstain of cell nuclei appears blue. A negative control is shown in the right panel.
图像 3 :
Alomone Labs AQP-005 图像 3
Western blot analysisof mouse salivary gland (1 and 3) and rat lung (2 and 4): - 12.Anti-Aquaporin 5Antibody (#AQP-005) (1:200).34. Anti-Aquaporin 5 Antibody preincubated with the control peptide antigen.
产品信息
SKU号 :
AQP-005_1_25_mcl
ParentSKU :
AQP-005
Taxonomy Node :
Primary Antibody>Intracellular>Non-Labeled
Action :
Insert
产品名称 :
抗水通道蛋白5抗体
产品描述 :
Anti-Aquaporin 5 Antibody (#AQP-005) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunocytochemistry and immunohistochemistry applications. It has been designed to recognize AQP5 from mouse, rat, and human samples.
Short Description :
A Rabbit Polyclonal Antibody to Aquaporin 5 Channel
Negative Control :
BLP-QP005
同义词 :
水通道蛋白5, AQP5
靶标名 :
Aquaporin 5 Channel
Primary Category (Old) :
Ion Channels > Aquaporins (Water Channels) > Antibodies to Aquaporins
标记/共轭标签 :
未共轭
应用 :
免疫细胞化学, IF, 免疫组化, 免疫印迹
宿主 :
兔
克隆性 :
多克隆
抗体亚型 :
兔IgG
基因符号 :
AQP5
反应物种 :
人类(试验);小鼠(试验);大鼠(试验)
同源 :
Mouse - identical; human - 10/16 amino acid residues identical.
靶标/背景信息 :
The importance of the aquaporin water channels was underscored by awarding the 2003 Nobel Prize in Chemistry to Peter Agre “for the discovery of water channels”. Today, eleven mammalian proteins that belong to the aquaporin family have been identified. The proteins present a conserved structure of six transmembrane domains with intracellular N- and C-termini.  Aquaporin 5 (AQP5) is expressed in secretory glands, lung and eye, where it works in modulating the rate of fluid release. Since a number of pathological conditions including pulmonary edema, respiratory distress syndrome and congestive heart failure are characterized by disrupted fluid transport, it has been suggested that modulation of the expression of AQP5 could be a novel modality of treatment of the above illnesses. Indeed, several studies have shown that AQP5 expression is downregulated in animal models of acute lung infection.
免疫原 :
合成肽
区域 :
intracellular
Loop :
Intracellular, C-terminus
序列 :
(C)DHREERKKTIELTAH corresponding to amino acid residues 251-265 of rat AQP5
序列文本 :
Peptide (C)DHREERKKTIELTAH corresponding to amino acid residues 251-265 of rat AQP5 (Accession number P47864). Intracellular, C-terminus.
Primary Size (Size+Units) :
1 X 25 mcl
浓度 :
0.4毫克/毫升
浓度 :
04毫克/毫升
缓冲液 :
磷酸盐缓冲液(PBS)
pH值 :
pH值7.4
防腐剂 :
1% BSA, 0.05% NaN3 (% of reconstituted antibody)
Additive(s) :
Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
格式(液体/冻干) :
冻干粉末
纯化来源(杂交瘤细胞, 腹水 :
Affinity purified on immobilized antigen
储存温度 :
-20°C
UniProt数据库 :
P47864
Top Related :
ACC-045, AAC-001, 蚂蚁-071, AQP-003, AQP-002
储存和重组 :
Reconstitution: 1 X 25 mcl double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
包装规格 :
1
产品规格/规格 :
25
单位 :
mcl
标价美国[美元] :
425美元
更多信息或购买 :
Alomone Labs 产品网页
公司信息
Alomone Labs
Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201
info@alomone.com
http://www.alomone.com
972-2-587-2202
公司总部: 以色列
Alomone Labs公司成立于1989年，在离子通道、GPCR及神经信号通路研究等领域占据全球领先地位。