产品简要
公司名称 :
American Research Products
产品类型 :
抗体
产品名称 :
Anti-CD44-Culture supernatant
目录 :
08-9406-1
规格 :
0.5毫升
价格 :
109.00美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定
更多信息或购买 :
产品信息
目录代码 :
08-9406-1
产品名称 :
Anti-CD44-Culture supernatant
宿主物种 :
小鼠
克隆性 :
单克隆
共轭 :
Culture Supernatant
产品类型 :
小鼠单克隆
规格 :
0.5毫升
标价 :
109.00美元
克隆 :
BRIC 222
抗体亚型 :
小鼠IgG1kappa照明链
产品描述 :
Mouse monoclonal antibody to human CD44 Culture supernatant. CD44 (also known as Pgp-1, ECMR III, Hermes antigen, p801, H- CAM) is a cell membrane glycoprotein of apparent molecular weight 80 kDa. The full amino acid sequence has been deduced from cDNA. It is heavily glycosylated with both N- and O- glycans. The extracellular part of CD44 comprises an N- terminal disulphide bonded domain and an O- glycosylated domain. CD44 carries the Ina and Inb blood group antigens2. There is a strong association between CD44 and the cytoskeleton. CD44 is thought to be involved in mediating cell:cell adhesion particularly lymphocyte- endothelial cell interactions important for lymphocyte migration from blood to lymph nodes and mucosal associated lymph organs. CD44 is a member of the hyaladherin family of hyaluronan-binding proteins, with a structure similar to selectins, and is the principal cell surface receptor for Hyaluronate3. Antibodies in CD44 may facilitate haemopoietic engraftment4. CD44 also functions as an adhesion, hyaluronan, fibronectin, osteopontin and MIP-1b receptor and as a co-stimulatory molecule. CD44 is found on a broad range of haemopoietic cells such as lymphoid cells, myeloid cells, fibroblasts, endothelial cells, epithelial cells, erythroid cells and the nervous system, but not platelets5. It is found on brain, heart, liver, thymus, kidney and colon epithelium. CD44 has been mapped to chromosome 11p13. There are approximately 10,000 CD44 molecules per erythrocyte.
特异性 :
BRIC 222 reacts by immunoblotting with a component of Mr 80kDa in nonreduced erythrocyte membranes. Epitope mapping correlates BRIC 222 with the Hermes 2 group of CD44 antibodies which is equivalent to epitope 16. This epitope appears to be associated with the N- terminal region of CD44. It inhibits T cell:erythrocyte rosette formation. BRIC 222 is a direct haemagglutinin. The erythrocyte antigen is pronase, rypsin, chymotrypsin and AET (2- aminoisothiouronium bromide) sensitive.
应用摘要 :
免疫印迹 , 酶联免疫吸附测定
储存 :
2-8°C for immediate use, or at -20°C (aliquot)
一般参考 :
1. Haynes, B.F. et al., (1989) Immunol. Today ,10, pp423-428 (Review).2. Spring, F.A., et al. (1988) Immunology ,64, pp 37-433. Aruffo, A., et al. (1990) Cell, 61, pp 1303-13134. Sandmaier, B.M. et al. (1990),76, pp 630-6355. Stoll, M. et al. (1989), in Leucocyte typing IV; White cell Differentiation Antigens, Ed. W. Knapp et al., Oxford University Press,pp6. Anstee DJ et al. (1991) Immunology, 74: 197-205 7. Spring et al. (1993) Proceedings of the fifth workshop and conference on white cell differentiation antigens, Boston, vol. 2p 1738-1740.
更多信息或购买 :
公司信息
American Research Products
135 Beaver Street, Suite 204
Waltham, MA 02452
info@arp1.com
www.arp1.com
800-832-2611 781-373-2182
公司总部: 美国