产品简要
公司名称 :
American Research Products
产品类型 :
蛋白
产品名称 :
IL-31
目录 :
19-C053
规格 :
10微克
价格 :
149.00美元
更多信息或购买 :
产品信息
目录代码 :
19-C053
产品名称 :
IL-31
产品类型 :
重组蛋白
规格 :
10微克
标价 :
149.00美元
产品描述 :
Human interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure.It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1.Human IL31 cDNA encodes a 164 amino acid precursor that contains a 23 aa signal peptide and a 141 aa mature protein. Human and mouse IL31 share 24% sequence identity in the mature region.IL 31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2). IL-31 signals via a heterodimeric receptor complex composed of a gp130 related molecule termed IL31RA (also GPL and GLMR) and a oncostatin M receptor (OSM Rbeta). The IL31 receptor is constitutively expressed by keratinocytes and upregulated by IFNgamma on monocytes. GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Studies have shown that IL31 induces severe pruritis (itching) and dermatitis in transgenic mice.
纯度 :
Greater than 95% as determined by reducing SDS-PAGE.
包装 :
Recombinant Human IL31 was lyophilized at 1mg/ml in 20mM PBS.
更多信息或购买 :
公司信息
American Research Products
135 Beaver Street, Suite 204
Waltham, MA 02452
info@arp1.com
www.arp1.com
800-832-2611 781-373-2182
公司总部: 美国