蛋白

TRAIL R2/TNFRSF10B

19-C326

10微克

99.00美元

TRAIL R2/TNFRSF10B

重组蛋白

10微克

99.00美元

TNFRSF10B,also known as DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2 and KILLER/DR5, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53.It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.

Greater than 95% as determined by reducing SDS-PAGE.

Recombinant Human TRAIL R2 was lyophilized at 1mg/ml in 20mM PBS.