产品简要
公司名称 :
Antibodies-online
产品类型 :
抗体
产品名称 :
anti-Integrin, alpha 4 (Antigen CD49D, alpha 4 Subunit of VLA-4 Receptor) (ITGA4) antibody (FITC)
目录 :
ABIN114227
规格 :
0.3毫克
价格 :
478.5美元
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
异硫氰酸荧光素
克隆名称 :
R1-2
反应物种 :
小鼠
应用 :
流式细胞仪, 流式细胞仪
更多信息或购买 :
Antibodies-online 产品网页
文章摘录数: 3
参考文献
Berlin C, Berg E, Briskin M, Andrew D, Kilshaw P, Holzmann B, et al. Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell. 1993;74:185-95 pubmed
Holzmann B, Weissman I. Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel. EMBO J. 1989;8:1735-41 pubmed
Holzmann B, McIntyre B, Weissman I. Identification of a murine Peyer's patch--specific lymphocyte homing receptor as an integrin molecule with an alpha chain homologous to human VLA-4 alpha. Cell. 1989;56:37-46 pubmed
图像
图像 1 :
Antibodies-online ABIN114227 图像 1
Rat anti CD49d (Integrin alpha 4 chain) R1-2
产品信息
目录代码 :
ABIN114227
产品名称 :
anti-Integrin, alpha 4 (Antigen CD49D, alpha 4 Subunit of VLA-4 Receptor) (ITGA4) antibody (FITC)
宿主物种 :
大鼠
克隆性 :
单克隆
共轭 :
异硫氰酸荧光素
抗原 :
CD49d/ITGA4
产品类型 :
Primary
规格 :
0.3毫克
标价美元 :
478.5美元
Pubmed号列表 :
2463092,2670559,7687523
图像 :
大鼠抗CD49d(整合素甲4链)R1-2
克隆 :
R1-2
抗体亚型 :
IgG2b
产品描述 :
Integrin alpha 4 (also called CD49d) is a 150 kDa protein that possesses a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain possessing multiple sites for phosphorylation. Integrin alpha 4 forms heterodimers with integrins beta 1 and beta 7. Integrin alpha 4 is expressed on leukocytes and leukocyte precursors, neural crest cells, and developing skeletal muscles and is essential for embryogenesis, hematopoiesis, and immune responses. The presence of integrin alpha 4 promotes cell migration and inhibits cell spreading and contractility. Integrin alpha 4 function has been implicated in the pathogenesis of multiple diseases including asthma, rheumatoid arthritis, Crohn's disease, ulcerative colitis, hepatitis C, and multiple sclerosis, and therefore, modulation of integrin alpha 4 function has become an important target for drug discovery.Synonyms: CD49 antigen-like family member D, Integrin alpha-4, Integrin alpha-IV, VLA-4, VLA4
免疫原 :
Peyers Patch HEV binding lymphoma line (TK1)
反应物种 :
Mouse (Murine)
缓冲液 :
PBS, 0.02 % NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.
浓度 :
0.1毫克/毫升
应用摘要 :
流式细胞仪(流式细胞仪)
UniProt数据库编号 :
Q00651
更多信息或购买 :
Antibodies-online 产品网页
公司信息
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
support@antibodies-online.com
www.antibodies-online.com
49-0-241-95-163-153
公司总部: 德国
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