抗体

anti-Fms-Related Tyrosine Kinase 4 (FLT4) (Extracellular Domain) antibody

ABIN115161

0.1毫克

412.5美元

单克隆

小鼠

nonconjugated

免疫印迹, 免疫组化, 酶免疫法, 免疫组化-冰冻切片

anti-Fms-Related Tyrosine Kinase 4 (FLT4) (Extracellular Domain) antibody

小鼠

单克隆

VEGFR-3 / Flt-4

Primary

0.1毫克

412.5美元

19564526,9563467

Western analysis (AP) using recombinant human soluble VEGFR-3/FLT-4 as target!

(3C3)9D9

IgG1

VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk 1) and VEGFR-3 (FLT-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of VEGFR-1 to -3 is almost exclusively restricted to hematopoietic precursor cells, vascular and lymphatic endothelial cells and to the monocyte/macrophage lineage. These receptors play essential roles in vasculogenesis, hematopoiesis, angiogenesis and lymphangiogenesis. The VEGFR-3 cDNA encodes a 1298 amino acid (aa) residue precursor protein with a 24 aa residue signal peptide. Mature VEGFR-3 is composed of a 751 aa residue extracellular domain, a 22 aa residue transmembrane domain and a 482 aa residue cytoplasmic domain. Both VEGF-C and VEGF-D have been shown to bind and activate VEGF R3 (Flt-4). The Flt-4 gene is widely expressed in the early embryo but becomes restricted to the lymphatic endothelial a latter stage of development. It is important for lymphangiogenesis.Synonyms: FLT4, Tyrosine-protein kinase receptor FLT4, VEGF Receptor 3, VEGFR3, Vascular endothelial growth factor receptor 3

Purified recombinant human Vascular Endothelial Growth Factor Receptor 3 (rh VEGFR-3/FLT-4) extracellular domain.

细胞外区域

人类

PBS pH 7.4 without preservatives or stabilizers

Enzyme Immunoassay (EIA),Immunohistochemistry (Frozen Sections) (IHC (fro)),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB)

P35916