产品简要
公司名称 :
Antibodies-online
产品类型 :
抗体
产品名称 :
抗胶质纤维酸性蛋白(GFAP)(pSer13)抗体
目录 :
ABIN1449159
规格 :
0.1毫克
价格 :
401.5美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
KT13
反应物种 :
人类
应用 :
免疫印迹, 免疫细胞化学
更多信息或购买 :
文章摘录数: 11
参考文献
Kawajiri A, Yasui Y, Goto H, Tatsuka M, Takahashi M, Nagata K, et al. Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase. Mol Biol Cell. 2003;14:1489-500 pubmed
Takemura M, Gomi H, Colucci Guyon E, Itohara S. Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice. J Neurosci. 2002;22:6972-9 pubmed
Takemura M, Nishiyama H, Itohara S. Distribution of phosphorylated glial fibrillary acidic protein in the mouse central nervous system. Genes Cells. 2002;7:295-307 pubmed
Nagata K, Izawa I, Inagaki M. A decade of site- and phosphorylation state-specific antibodies: recent advances in studies of spatiotemporal protein phosphorylation. Genes Cells. 2001;6:653-64 pubmed
Yasui Y, Amano M, Nagata K, Inagaki N, Nakamura H, Saya H, et al. Roles of Rho-associated kinase in cytokinesis; mutations in Rho-associated kinase phosphorylation sites impair cytokinetic segregation of glial filaments. J Cell Biol. 1998;143:1249-58 pubmed
Inagaki M, Inagaki N, Takahashi T, Takai Y. Phosphorylation-dependent control of structures of intermediate filaments: a novel approach using site- and phosphorylation state-specific antibodies. J Biochem. 1997;121:407-14 pubmed
Kosako H, Amano M, Yanagida M, Tanabe K, Nishi Y, Kaibuchi K, et al. Phosphorylation of glial fibrillary acidic protein at the same sites by cleavage furrow kinase and Rho-associated kinase. J Biol Chem. 1997;272:10333-6 pubmed
MacAulay C, Forbes D. Assembly of the nuclear pore: biochemically distinct steps revealed with NEM, GTP gamma S, and BAPTA. J Cell Biol. 1996;132:5-20 pubmed
Inagaki N, Ito M, Nakano T, Inagaki M. Spatiotemporal distribution of protein kinase and phosphatase activities. Trends Biochem Sci. 1994;19:448-52 pubmed
Nishizawa K, Yano T, Shibata M, Ando S, Saga S, Takahashi T, et al. Specific localization of phosphointermediate filament protein in the constricted area of dividing cells. J Biol Chem. 1991;266:3074-9 pubmed
Matsuoka Y, Nishizawa K, Yano T, Shibata M, Ando S, Takahashi T, et al. Two different protein kinases act on a different time schedule as glial filament kinases during mitosis. EMBO J. 1992;11:2895-902 pubmed
图像
图像 1 :
Antibodies-online ABIN1449159 图像 1
产品信息
目录代码 :
ABIN1449159
产品名称 :
抗胶质纤维酸性蛋白(GFAP)(pSer13)抗体
宿主物种 :
小鼠
克隆性 :
单克隆
抗原 :
GFAP
产品类型 :
Primary
规格 :
0.1毫克
标价美元 :
401.5美元
Pubmed号列表 :
8567730,12686604,12177195,11918673,11532025,9832553,9099667,9133607,7855885,1379174,1993680
克隆 :
KT13
抗体亚型 :
IgG1
产品描述 :
Intermediate filaments (IFs) constitute major components of the cytoskeleton and the nuclear envelope in most cell types. Unlike other cytoskeletons such as microtubules and actin filaments, the protein components of IFs vary in a cell-, tissue-, and differentiation-dependent manner. Although IFs were thought to be relatively stable compared with actin filaments and microtubules, intensive in vitro investigations revealed that site-specific phosphorylation by several kinases, such as protein kinase A (PKA), protein kinase C (PKC), Ca2+/Calmodulin kinase II (CaMKII), cdc2 kinase, and Rho-kinase alters dynamically their structure and induces filament disruption. Glial fibrillary acidic protein (GFAP) belongs to IF proteins. GFAP is a useful marker of mature astrocytes and mutation in the GFAP gene has recently been associated with Alexander disease. Inagaki et al. reported that GFAP was phosphorylated specifically at Thr-7, Ser-13, and Ser-34 by Rho-kinase and Aurora-B and all of these sites were phosphorylated at the cleavage furrow during cytokinesis.Synonyms: Glial Fibrillary Acidic Protein
免疫原 :
KLH-pG13肽
表位 :
pSer13
反应物种 :
人类
缓冲液 :
PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
浓度 :
1.0毫克/毫升
应用摘要 :
免疫荧光(IF), 免疫印迹(免疫印迹)
UniProt数据库编号 :
P14136
更多信息或购买 :
公司信息
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