抗体

抗激酶插入域受体(A类型III受体酪氨酸激酶)(激酶插入区受体)(pTyr1214)抗体

ABIN196769

50微升

280.5美元

多克隆

兔

nonconjugated

免疫印迹, 免疫组化, 免疫细胞化学

抗激酶插入域受体(A类型III受体酪氨酸激酶)(激酶插入区受体)(pTyr1214)抗体

兔

多克隆

CD309 / VEGFR-2 / Flk-1

Primary

50微升

280.5美元

14724572,11387210

VEGF receptor 2 is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2 and phosphotyrosine binding containing signalling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.Synonyms: FLK1, KDR, Kinase NYK, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, VEGF Receptor 2, VEGFR2, Vascular endothelial growth factor receptor 2

Synthetic phosphopeptide derived from human VEGFR2 around the phosphorylation site of tyrosine 1214 (F-H-YP-D-N).

pTyr1214

人类

PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.

1.0毫克/毫升

免疫荧光(IF), 免疫组化(石蜡包埋切片)(免疫组化(p)), 免疫印迹(免疫印迹)

P35968