产品简要
公司名称 :
Antibodies-online
产品类型 :
抗体
产品名称 :
抗肿瘤蛋白P53(TP53)(氨基酸378-393),(C末端),(pSer392)抗体
目录 :
ABIN238404
规格 :
0.1毫克
价格 :
324.5美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
FP3-2
反应物种 :
人类
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
文章摘录数: 6
| 参考文献 |
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Tanigawa S, Fujii M, Hou D. Stabilization of p53 is involved in quercetin-induced cell cycle arrest and apoptosis in HepG2 cells. Biosci Biotechnol Biochem. 2008;72:797-804 pubmed
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Blaydes J, Craig A, Wallace M, Ball H, Traynor N, Gibbs N, et al. Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways. Oncogene. 2000;19:3829-39 pubmed
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Taylor W, DePrimo S, Agarwal A, Agarwal M, Schonthal A, Katula K, et al. Mechanisms of G2 arrest in response to overexpression of p53. Mol Biol Cell. 1999;10:3607-22 pubmed
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Taylor W, Agarwal M, Agarwal A, Stacey D, Stark G. p53 inhibits entry into mitosis when DNA synthesis is blocked. Oncogene. 1999;18:283-95 pubmed
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Agarwal M, Agarwal A, Taylor W, Chernova O, Sharma Y, Stark G. A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides. Proc Natl Acad Sci U S A. 1998;95:14775-80 pubmed
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Agarwal M, Agarwal A, Taylor W, Stark G. p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc Natl Acad Sci U S A. 1995;92:8493-7 pubmed
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图像
图像 1 :
产品信息
目录代码 :
ABIN238404
产品名称 :
抗肿瘤蛋白P53(TP53)(氨基酸378-393),(C末端),(pSer392)抗体
宿主物种 :
小鼠
克隆性 :
单克隆
抗原 :
p53(TP53)
产品类型 :
Primary
规格 :
0.1毫克
标价美元 :
324.5美元
Pubmed号列表 :
10564259,18323654,7667317,9843965,9927185,10951576
克隆 :
FP3-2
抗体亚型 :
IgG1
产品描述 :
The tumour suppressor protein p53 is a key element of intracellular anticancer protection. It mediates cell cycle arrest or apoptosis in response to DNA damage or to starvation for pyrimidine nukleotides. It is up-regulated in response to these stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest, or proteins that trigger apoptosis, such as Bcl-2. The structure of p53 comprises N-terminal transactivation domain, central DNA-binding domain, oligomerisation domain, and C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization.Synonyms: Cellular tumor antigen p53, NY-CO-13, Phosphoprotein p53, Tumor suppressor p53
免疫原 :
KLH-conjugated phosphopeptide RHKKLMFKTEGPDS[P] corresponding to amino acids378-393 representing the C-terminus of Human p53.
表位 :
氨基酸378-393, C末端, pSer392
反应物种 :
人类
缓冲液 :
PBS, pH ~7.4, 15 mM Sodium Azide
浓度 :
1.0毫克/毫升
应用摘要 :
免疫组化(石蜡包埋切片)(免疫组化(p)), 免疫印迹(免疫印迹)
UniProt数据库编号 :
P04637
更多信息或购买 :
公司信息
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
support@antibodies-online.com
www.antibodies-online.com49-0-241-95-163-153
公司总部: 德国
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