抗体

anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (pSer129) antibody

ABIN358075

0.4毫升

357.5美元

多克隆

兔

nonconjugated

免疫印迹, 免疫组化, 酶免疫法

anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (pSer129) antibody

兔

多克隆

AKT1/PKB

Primary

0.4毫升

357.5美元

9690513,16397149,11696554,18669648

Ig

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.Synonyms: Akt-1, C-AKT, Protein kinase B, RAC-PK-alpha, RAC-alpha serine/threonine-protein kinase

This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S129 of human AKT1.

pSer129

人类

PBS with 0.09 % (W/V) Sodium Azide as preservative.

0.25毫克/毫升

酶免疫法(EIA), 免疫组化(石蜡包埋切片)(免疫组化(p)), 免疫印迹(免疫印迹)

P31749