产品简要
公司名称 :
Antibodies-online
产品类型 :
抗体
产品名称 :
anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (C-Term) antibody
目录 :
ABIN400791
规格 :
25微升
价格 :
253美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
18F10-E5
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫沉淀, 酶免疫法, 免疫组化-冰冻切片
更多信息或购买 :
Antibodies-online 产品网页
文章摘录数: 4
参考文献
Lawlor M, Alessi D. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?. J Cell Sci. 2001;114:2903-10 pubmed
Alessi D. Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture. Biochem Soc Trans. 2001;29:1-14 pubmed
Staal S. Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci U S A. 1987;84:5034-7 pubmed
Jones P, Jakubowicz T, Pitossi F, Maurer F, Hemmings B. Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. Proc Natl Acad Sci U S A. 1991;88:4171-5 pubmed
图像
图像 1 :
Antibodies-online ABIN400791 图像 1
产品信息
目录代码 :
ABIN400791
产品名称 :
anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (C-Term) antibody
宿主物种 :
小鼠
克隆性 :
单克隆
抗原 :
AKT1/PKB
产品类型 :
Primary
规格 :
25微升
标价美元 :
253美元
Pubmed号列表 :
1851997,3037531,11686294,11356119
克隆 :
18F10-E5
抗体亚型 :
IgG1
产品描述 :
AKT is a component of the PI-3 kinase pathway and is activated by phosphorylation at Ser 473 and Thr 308. AKT is a cytoplasmic protein also known as AKT1, Protein Kinase B (PKB) and rac (related to A and C kinases). AKT is a key regulator of many signal transduction pathways. AKT exhibits tight control over cell proliferation and cell viability. Overexpression or inappropriate activation of AKT is noted in many types of cancer. AKT mediates many of the downstream events of PI 3-kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3-kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, AKT dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus. AKT has two main roles: (i) inhibition of apoptosis, (ii) promotion of proliferation.Synonyms: Akt-1, C-AKT, Protein kinase B, RAC-PK-alpha, RAC-alpha serine/threonine-protein kinase
免疫原 :
Synthetic peptide corresponding to residues near the C terminal end of of Human AKT1protein
表位 :
C末端
反应物种 :
Human,Mouse (Murine)
缓冲液 :
0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide as preservative.
浓度 :
1.0 mg/mL (by UV absorbance at 280 nm)
应用摘要 :
Immunohistochemistry (Frozen Sections) (IHC (fro)),Enzyme Immunoassay (EIA),Immunoprecipitation (IP),Western Blotting (WB)
UniProt数据库编号 :
P31749
更多信息或购买 :
Antibodies-online 产品网页
公司信息
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
support@antibodies-online.com
www.antibodies-online.com
49-0-241-95-163-153
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