抗体

anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (pThr450) antibody

ABIN650890

400微升

291.5美元

多克隆

兔

nonconjugated

RB29255

anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (pThr450) antibody

兔

多克隆

AKT1

Primary

400微升

291.5美元

20808831

Dot blot analysis of anti-Phospho-AKT1-T450 Antibody Phospho-specific Pab (ABIN650890) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6 µg/mL.

RB29255

Ig

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]. Synonyms: RAC-alpha serine/threonine-protein kinase,AKT1,PKB, RAC

This AKT1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T450 of human AKT1.

pThr450

人类

PBS with 0.09 % (W/V) sodium azide

0.5毫克/毫升

Dot Blot (DB)

P31749