产品简要
公司名称 :
Antibodies-online
产品类型 :
抗体
产品名称 :
anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (AA 282-309), (Thr308) antibody
目录 :
ABIN654500
规格 :
400微升
价格 :
291.5美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
克隆名称 :
RB27685
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 流式细胞仪, 流式细胞仪
更多信息或购买 :
文章摘录数: 1
参考文献
Chen J, Gomes A, Monteiro L, Wong S, Wu L, Ng T, et al. Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer. PLoS ONE. 2010;5:e12293 pubmed 出版商
图像
图像 1 :
Antibodies-online ABIN654500 图像 1
AKT1 Antibody (Thr308) (ABIN654500) flow cytometric analysis of MDA-MB435 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
产品信息
目录代码 :
ABIN654500
产品名称 :
anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (AA 282-309), (Thr308) antibody
宿主物种 :
克隆性 :
多克隆
抗原 :
AKT1
产品类型 :
Primary
规格 :
400微升
标价美元 :
291.5美元
Pubmed号列表 :
20808831
图像 :
AKT1 Antibody (Thr308) (ABIN654500) flow cytometric analysis of MDA-MB435 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
克隆 :
RB27685
抗体亚型 :
Ig
产品描述 :
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]. Synonyms: AKT1,RAC-alpha serine/threonine-protein kinase,PKB, RAC
免疫原 :
This AKT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-309 AA from human AKT1.
表位 :
氨基酸282-309, Thr308
反应物种 :
人类
缓冲液 :
PBS with 0.09 % (W/V) sodium azide
浓度 :
0.5毫克/毫升
应用摘要 :
流式细胞仪(流式细胞仪), 免疫组化(石蜡包埋切片)(免疫组化(p)), 免疫印迹(免疫印迹)
UniProt数据库编号 :
P31749
更多信息或购买 :
公司信息
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
support@antibodies-online.com
www.antibodies-online.com
49-0-241-95-163-153
公司总部: 德国
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