产品简要
公司名称 :
Aviva Systems Biology
产品类型 :
抗体
产品名称 :
SHH抗体-N末端地区(ARP44235_P050)
目录 :
ARP44235
规格 :
100微升
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, , , , 斑马鱼
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
产品信息
SKU号 :
ARP44235
产品类型 :
多克隆抗体
类别 :
多克隆
名称 :
SHH抗体-N末端地区(ARP44235_P050)
规格 :
100微升
基因符号 :
SHH
alias symbols :
HHG1, HLP3, HPE3, SMMCI, TPT, TPTPS, MCOPCB5
nucleotide accession num :
NM_000193
protein accession num :
NP_000184
SwissProt号 :
Q15465
物种活性 :
牛, 狗, 山羊, 豚鼠, 马, 人类, 小鼠, 兔, 大鼠, 斑马鱼, 鸡
产品格式 :
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
肽序列 :
RCLLLVLVSSLLVCSGLACGPGRGFGKRRHPKKLTPLAY
KQFIPNVAEKT
Synthetic peptide located within the following region:
重组和储存 :
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
description of target :
SHH is a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE). It is also thought that mutations in its gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities.This gene, which is expressed only during embryogenesis, encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. In addition, it is thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities.
宿主 :
应用 :
免疫组化, 免疫印迹
同源 :
Cow: 93%; Dog: 100%; Goat: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
纯化 :
亲和纯化
克隆性 :
多克隆
免疫原 :
The immunogen is a synthetic peptide directed towards the N terminal region of human SHH
drywet surcharge :
Wet Ice
储存温度 :
-20C
更多信息或购买 :
公司信息
Aviva Systems Biology
7700 Ronson Road, Ste 100, San Diego, CA 92111
techsupport@avivasysbio.com
http://www.avivasysbio.com
1-858-552-6979
公司总部: 美国