抗体

肿瘤坏死因子受体超家族成员1A抗体-N末端地区(AVARP00034_P050)

AVARP00034

100微升

多克隆

domestic rabbit

未共轭

人类, 小鼠

免疫印迹, 免疫细胞化学

多克隆抗体

多克隆

肿瘤坏死因子受体超家族成员1A抗体-N末端地区(AVARP00034_P050)

100微升

肿瘤坏死因子受体超家族成员1A

CD120a, FPF, MGC19588, TBP1, 肿瘤坏死因子-R, 肿瘤坏死因子-R, 肿瘤坏死因子-R55, TNFAR, TNFR1, TNFR55, TNFR60, p55, p55-R, p60

NM_001065

NP_001056

P19438

豚鼠, 人类, 小鼠

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREK
RDSVCPQGKYI
Synthetic peptide located within the following region:

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

TNFRSF1A is the receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNFRSF1A contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

兔

IF, 免疫印迹

Guinea Pig: 84%; Human: 100%; Mouse: 92%

亲和纯化

多克隆

The immunogen is a synthetic peptide directed towards the N terminal region of human TNFRSF1A

Wet Ice

-20C