ELISA/assay

IL1B酶联免疫吸附试剂盒(人类)(OKBB00176)

OKBB00176

96试验

Application Kit

酶联免疫吸附试剂盒

IL1B酶联免疫吸附试剂盒(人类)(OKBB00176)

96试验

IL1B

IL-1I, 白细胞介素1b, 白细胞介素1I, 白细胞介素1β, IL1B

NM_000576.2

NP_000567.1

P01584

人类

Store as indicated in product manual.

Interleukin-1beta ( IL-1beta) is a potent stimulator of bone resorption whose gene is mapped to 2q14, and has been implicated in the pathogenesis of high bone turnover and osteoporosis. IL-1beta, a prominent microglia-derived cytokine, caused oligodendrocyte death in coculture with astrocytes and microglia, but not in pure culture of oligodendrocytes alone1. It also can cause nuclear export of a specific NCOR corepressor complex, resulting in derepression of a specific subset of nuclear factor-kappa-B (NFKB)-regulated genes2. Furthermore, Microenvironmental IL-1beta and, to a lesser extent, IL-1alpha are required for in vivo angiogenesis and invasiveness of different tumor cells3. Additional, the cooperation of IL-1beta and PDGFB induces contractile-to-synthetic phenotype modulation of human aortic smooth muscle cells in culture4. Moreover, the association with disease may be explained by the biologic properties of IL-1beta, which is an important proinflammatory cytokine and a powerful inhibitor of gastric acid secretion5.

酶联免疫吸附测定

No detectable cross-reactivity with any other cytokine.

< 0.15 pg/ml

There is no detectable cross-reactivity with other relevant proteins.

Wet Ice

4C