ELISA/assay

基质金属蛋白酶-2酶联免疫吸附试剂盒(人类)(OKBB00220)

OKBB00220

96试验

Application Kit

酶联免疫吸附试剂盒

基质金属蛋白酶-2酶联免疫吸附试剂盒(人类)(OKBB00220)

96试验

MMP2

CLG4, MONA, CLG4A, 基质金属蛋白酶-2, TBE-1, 基质金属蛋白酶-II

NM_001127891.2

NP_001121363.1

P08253

人类

Store as indicated in product manual.

Type IV collagenase, 72-kD, is officially designated matrix metalloproteinase-2 (MMP2). It is also known as gelatinase, 72-kD. MMP-2 plays an essential role in angiogenesis and arteriogenesis, two processes critical to restoration of tissue perfusion after ischemia. MMP-2 expression is increased in tissue ischemia, but the responsible mechanisms remain unknown.1 Matrix metalloproteinases (MMPs) catalyze extracellular matrix degradation. Control of their activity is a promising target for therapy of diseases characterized by abnormal connective tissue turnover. MMPs are expressed as latent proenzymes that are activated by proteolytic cleavage that triggers a conformational change in the propeptide (cysteine switch). The structure of proMMP-2 reveals how the propeptide shields the catalytic cleft and that the cysteine switch may operate through cleavage of loops essential for propeptide stability.2 The gene is localized to 16q21 using somatic cell hybrids and in situ hybridization.3 The standard product used in this kit is recombinant human MMP-2, consisting of 631 amino acids with the molecular mass of 71KDa. The detected MMP-2 includes zymogen and active enzyme.

酶联免疫吸附测定

< 10 pg/mL

Natural and recombinant human total MMP-2. There is no detectable cross-reactivity with other relevant proteins.

Wet Ice

4C