ELISA/assay

KRAS酶联免疫吸附试剂盒(人类)(OKCD01039)

OKCD01039

96 Wells

Application Kit

酶联免疫吸附试剂盒

KRAS酶联免疫吸附试剂盒(人类)(OKCD01039)

96 Wells

KRAS

c-Ki-ras, c-K-ras, C-K-RAS, GTPase KRas, Ki-Ras, KI-RAS, KRAS1, KRAS2, K-Ras 2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, NS, NS3, RASK2

NM_004985.4

NP_004976

P01116

人类

Store as indicated in product manual.

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF34-dependent manner (PubMed:2462336).Curated3 Publications p>Manually curated information for which there is published experimental evidence. /p> a href="/manual/evidences#ECO:269">More… /a> /p> Manual assertion based on experiment iniRef.2"Regulation of RAS oncogenicity by acetylation." Yang M.H., Nickerson S., Kim E.T., Liot C., Laurent G., Spang R., Philips M.R., Shan Y., Shaw D.E., Bar-Sagi D., Haigis M.C., Haigis K.M. Proc. Natl. Acad. Sci. U.S.A. 19:1843-1848(212) [PubMed] [Europe PMC] [Abstract]Cited for: ACETYLATION AT LYS-14, VARIANT VAL-12, FUNCTION, ENZYME REGULATION.Ref.21"Small molecule inhibition of the KRAS-PDE? interaction impairs oncogenic KRAS signalling." Zimmermann G., Papke B., Ismail S., Vartak N., Chandra A., Hoffmann M., Hahn S.A., Triola G., Wittinghofer A., Bastiaens P.I., Waldmann H. Nature 497:638-642(213) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PDE6D.Ref.22"A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype." Serra R.W., Fang M., Park S.M., Hutchinson L., Green M.R. Elife 3:E2313-E2313(214) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CHARACTERIZATION OF VARIANT COLON CANCER VAL-12.

酶联免疫吸附测定

Assay Methodology: Quantitative Sandwich Immunoassay

< 0.125 ng/mL

This assay has high sensitivity and excellent specificity for detection of V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS). No significant cross-reactivity or interference between V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) and analogues was observed.

Wet Ice

4C