ELISA/assay

MUSK酶联免疫吸附试剂盒(小鼠)(OKCD02738)

OKCD02738

96 Wells

Application Kit

酶联免疫吸附试剂盒

MUSK酶联免疫吸附试剂盒(小鼠)(OKCD02738)

96 Wells

MUSK

Mdk4, MDK4, MGC117677, Mlk, Muscle, skeletal receptor tyrosine-protein kinase, Muscle-specific kinase receptor, Muscle-specific tyrosine-protein kinase receptor, MuSK, Nsk1, Nsk2, Nsk3

NM_001037128.1

NP_001032205.1

Q61006

小鼠

Store as indicated in product manual.

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation.

Assay Methodology: Quantitative Sandwich ELISA

0.061 ng/mL

This assay has high sensitivity and excellent specificity for detection of Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK). No significant cross-reactivity or interference between Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) and analogues was observed.

Wet Ice

2-8C