产品简要
公司名称 :
碧迪BD
其他品牌 :
Transduction Laboratories, PharMingen, Difco
产品类型 :
抗体
产品名称 :
CD4
目录 :
553726
规格 :
0.5毫克
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
GK1.5
反应物种 :
人类, 小鼠
应用 :
免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-冰冻切片, 其他
更多信息或购买 :
文章摘录数: 65
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠
Neumann S, Campbell K, Woodall M, Evans M, Clarkson A, Young S. Obesity Has a Systemic Effect on Immune Cells in Naïve and Cancer-Bearing Mice. Int J Mol Sci. 2021;22: pubmed 出版商
  • 流式细胞仪; 小鼠; 1:400; 图 3c, s2b, s4d
Moreira T, Mangani D, Cox L, Leibowitz J, Lobo E, Oliveira M, et al. PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis. Nat Commun. 2021;12:4907 pubmed 出版商
  • 免疫组化; 小鼠; 1:200
Amoozgar Z, Kloepper J, Ren J, Tay R, Kazer S, Kiner E, et al. Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas. Nat Commun. 2021;12:2582 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3b
Yang C, Kwon D, Kim M, Im S, Lee Y. Commensal Microbiome Expands Tγδ17 Cells in the Lung and Promotes Particulate Matter-Induced Acute Neutrophilia. Front Immunol. 2021;12:645741 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:200; 图 7b
Borges P, Waclawiak I, Georgii J, Fraga Junior V, Barros J, Lemos F, et al. Adenosine Diphosphate Improves Wound Healing in Diabetic Mice Through P2Y12 Receptor Activation. Front Immunol. 2021;12:651740 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:200; 图 5a
Gao L, Li B, Wang J, Shen D, Yang M, Sun R, et al. Activation of Liver X Receptor α Sensitizes Mice to T-Cell Mediated Hepatitis. Hepatol Commun. 2020;4:1664-1679 pubmed 出版商
  • 流式细胞仪; 小鼠
Myers D, Abram C, Wildes D, Belwafa A, Welsh A, Schulze C, et al. Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity. Front Immunol. 2020;11:576310 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s3e
Luker A, Graham L, Smith T, Camarena C, Zellner M, Gilmer J, et al. The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer. BMC Immunol. 2020;21:8 pubmed 出版商
  • 免疫组化; 小鼠; 图 2e
Choi S, Bae H, Jeong S, Park I, Cho H, Hong S, et al. YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells. Nat Commun. 2020;11:519 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2a
Kotov J, Kotov D, Linehan J, Bardwell V, Gearhart M, Jenkins M. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. J Exp Med. 2019;216:1450-1464 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:100; 图 s2a, s2b
Aarts S, Seijkens T, Kusters P, Van Tiel C, Reiche M, den Toom M, et al. Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis. J Pathol. 2019;247:471-480 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s1c
Walsh S, Bastin D, Chen L, Nguyen A, Storbeck C, Lefebvre C, et al. Type I IFN blockade uncouples immunotherapy-induced antitumor immunity and autoimmune toxicity. J Clin Invest. 2019;129:518-530 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 7c
Wang H, D Souza C, Lim X, Kostenko L, Pediongco T, Eckle S, et al. MAIT cells protect against pulmonary Legionella longbeachae infection. Nat Commun. 2018;9:3350 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5b
White E, Gyulay G, Lhotak S, Szewczyk M, Chong T, Fuller M, et al. Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice. J Biol Chem. 2018;293:14689-14706 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 4g
Gisterå A, Klement M, Polyzos K, Mailer R, Duhlin A, Karlsson M, et al. LDL-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice. Circulation. 2018;: pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s18
Vendetti F, Karukonda P, Clump D, Teo T, Lalonde R, Nugent K, et al. ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation. J Clin Invest. 2018;128:3926-3940 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 4a
Kyung D, Sung H, Kim Y, Kim K, Cho S, Choi J, et al. Global transcriptome analysis identifies weight regain-induced activation of adaptive immune responses in white adipose tissue of mice. Int J Obes (Lond). 2018;42:755-764 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2b
  • 免疫组化; 小鼠; 图 5e
Stefani F, Eberstål S, Vergani S, Kristiansen T, Bengzon J. Low-dose irradiated mesenchymal stromal cells break tumor defensive properties in vivo. Int J Cancer. 2018;143:2200-2212 pubmed 出版商
  • 免疫组化; 小鼠; 图 1a
Westhorpe C, Norman M, Hall P, Snelgrove S, Finsterbusch M, Li A, et al. Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes. Nat Commun. 2018;9:747 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:200; 图 2a
Guimarães G, Gomes M, Campos P, Marinho F, de Assis N, Silveira T, et al. Immunoproteasome Subunits Are Required for CD8+ T Cell Function and Host Resistance to Brucella abortus Infection in Mice. Infect Immun. 2018;86: pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1a
Burrack A, Malhotra D, Dileepan T, Osum K, Swanson L, Fife B, et al. Cutting Edge: Allograft Rejection Is Associated with Weak T Cell Responses to Many Different Graft Leukocyte-Derived Peptides. J Immunol. 2018;200:477-482 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Torcellan T, Hampton H, Bailey J, Tomura M, Brink R, Chtanova T. In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors. Proc Natl Acad Sci U S A. 2017;114:5677-5682 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1d
Laffont S, Blanquart E, Savignac M, Cenac C, Laverny G, Metzger D, et al. Androgen signaling negatively controls group 2 innate lymphoid cells. J Exp Med. 2017;214:1581-1592 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s4c
Chowdhary V, Krogman A, Tilahun A, Alexander M, David C, Rajagopalan G. Concomitant Disruption of CD4 and CD8 Genes Facilitates the Development of Double Negative ?? TCR+ Peripheral T Cells That Respond Robustly to Staphylococcal Superantigen. J Immunol. 2017;198:4413-4424 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s1c
Berghoff S, Gerndt N, Winchenbach J, Stumpf S, Hosang L, Odoardi F, et al. Dietary cholesterol promotes repair of demyelinated lesions in the adult brain. Nat Commun. 2017;8:14241 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2a
Wei Y, Lu C, Chen J, Cui G, Wang L, Yu T, et al. High salt diet stimulates gut Th17 response and exacerbates TNBS-induced colitis in mice. Oncotarget. 2017;8:70-82 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5c
Yanagisawa H, Hashimoto M, Minagawa S, Takasaka N, Ma R, Moermans C, et al. Role of IL-17A in murine models of COPD airway disease. Am J Physiol Lung Cell Mol Physiol. 2017;312:L122-L130 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 6
Serr I, Fürst R, Ott V, Scherm M, Nikolaev A, Gökmen F, et al. miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity. Proc Natl Acad Sci U S A. 2016;113:E6659-E6668 pubmed
  • 流式细胞仪; 小鼠; 图 s1b
Coursey T, Bian F, Zaheer M, Pflugfelder S, Volpe E, de Paiva C. Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells. Mucosal Immunol. 2017;10:743-756 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 4a
Chow K, Delconte R, Huntington N, Tarlinton D, Sutherland R, Zhan Y, et al. Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells. J Immunol. 2016;197:2000-8 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5b
Keil M, Sonner J, Lanz T, Oezen I, Bunse T, Bittner S, et al. General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation. J Neuroimmunol. 2016;297:117-26 pubmed 出版商
  • 流式细胞仪; 小鼠
Kathania M, Khare P, Zeng M, Cantarel B, Zhang H, Ueno H, et al. Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-?t ubiquitination. Nat Immunol. 2016;17:997-1004 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s1b
De Grove K, Provoost S, Hendriks R, McKenzie A, Seys L, Kumar S, et al. Dysregulation of type 2 innate lymphoid cells and TH2 cells impairs pollutant-induced allergic airway responses. J Allergy Clin Immunol. 2017;139:246-257.e4 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s1a
Sujino T, London M, Hoytema van Konijnenburg D, Rendon T, Buch T, Silva H, et al. Tissue adaptation of regulatory and intraepithelial CD4? T cells controls gut inflammation. Science. 2016;352:1581-6 pubmed 出版商
  • 其他; 小鼠
Wen S, Dooner M, Cheng Y, Papa E, Del Tatto M, Pereira M, et al. Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells. Leukemia. 2016;30:2221-2231 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s8
Ueno M, Ueno Nakamura Y, Niehaus J, Popovich P, Yoshida Y. Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury. Nat Neurosci. 2016;19:784-7 pubmed 出版商
  • 流式细胞仪; 小鼠
Maelfait J, Roose K, Vereecke L, Mc Guire C, Sze M, Schuijs M, et al. A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection. PLoS Pathog. 2016;12:e1005410 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2b
Wei R, Hu Y, Dong F, Xu X, Hu A, Gao G. Hepatoma cell-derived leptin downregulates the immunosuppressive function of regulatory T-cells to enhance the anti-tumor activity of CD8+ T-cells. Immunol Cell Biol. 2016;94:388-99 pubmed 出版商
  • 流式细胞仪; 人类; 1:200
Riesenberg S, Groetchen A, Siddaway R, Bald T, Reinhardt J, Smorra D, et al. MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment. Nat Commun. 2015;6:8755 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 7
Black L, Srivastava R, Schoeb T, Moore R, Barnes S, KABAROWSKI J. Cholesterol-Independent Suppression of Lymphocyte Activation, Autoimmunity, and Glomerulonephritis by Apolipoprotein A-I in Normocholesterolemic Lupus-Prone Mice. J Immunol. 2015;195:4685-98 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Yu J, Hoffman S, Beal A, Dykon A, Ringenberg M, Hughes A, et al. MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses. PLoS ONE. 2015;10:e0127083 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3A
Shao L, Lie A, Zhang Y, Wong C, Kwong Y. Aberrant germinal center formation, follicular T-helper cells, and germinal center B-cells were involved in chronic graft-versus-host disease. Ann Hematol. 2015;94:1493-504 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
  • 免疫细胞化学; 小鼠; 图 4
Thiault N, Darrigues J, Adoue V, Gros M, Binet B, Pérals C, et al. Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors. Nat Immunol. 2015;16:628-34 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1a
Becker P, Hervouet C, Mason G, KWON S, Klavinskis L. Skin vaccination with live virus vectored microneedle arrays induce long lived CD8(+) T cell memory. Vaccine. 2015;33:4691-8 pubmed 出版商
  • 流式细胞仪; 小鼠
Sakala I, Chaudhri G, Eldi P, Buller R, Karupiah G. Deficiency in Th2 cytokine responses exacerbate orthopoxvirus infection. PLoS ONE. 2015;10:e0118685 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 7a
Mang Y, Zhao Z, Zeng Z, Wu X, Li Z, Zhang L. Efficient elimination of CD103-expressing cells by anti-CD103 antibody drug conjugates in immunocompetent mice. Int Immunopharmacol. 2015;24:119-27 pubmed 出版商
  • 流式细胞仪; 小鼠
Kim K, Skora A, Li Z, Liu Q, Tam A, Blosser R, et al. Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells. Proc Natl Acad Sci U S A. 2014;111:11774-9 pubmed 出版商
  • 流式细胞仪; 小鼠
Vegran F, Berger H, Boidot R, Mignot G, Bruchard M, Dosset M, et al. The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells. Nat Immunol. 2014;15:758-66 pubmed 出版商
  • 流式细胞仪; 小鼠
Gaughan A, Wang J, Pelletier R, Nadasdy T, Brodsky S, Roy S, et al. Key role for CD4 T cells during mixed antibody-mediated rejection of renal allografts. Am J Transplant. 2014;14:284-94 pubmed 出版商
  • 流式细胞仪; 小鼠
Hu Y, Xiao H, Shi T, Oppenheim J, Chen X. Progranulin promotes tumour necrosis factor-induced proliferation of suppressive mouse CD4? Foxp3? regulatory T cells. Immunology. 2014;142:193-201 pubmed 出版商
  • 流式细胞仪; 小鼠
Qu S, Ou Yang H, He Y, Li Z, Shi J, Song L, et al. Der p2 recombinant bacille Calmette-Guerin priming of bone marrow-derived dendritic cells suppresses Der p2-induced T helper17 function in a mouse model of asthma. Respirology. 2014;19:122-31 pubmed 出版商
  • 免疫组化; 小鼠
Weng T, Huang S, Yen M, Lin C, Chen Y, Lin C, et al. A novel cancer therapeutic using thrombospondin 1 in dendritic cells. Mol Ther. 2014;22:292-302 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠
Coffey F, Manser T. Expression of cellular FLIP by B cells is required for their participation in an immune response. J Immunol. 2010;184:4871-9 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1
Borsellino G, Kleinewietfeld M, Di Mitri D, Sternjak A, Diamantini A, Giometto R, et al. Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood. 2007;110:1225-32 pubmed
Wasiuk A, Testa J, Weidlick J, Sisson C, Vitale L, Widger J, et al. CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy. J Immunol. 2017;199:4110-4123 pubmed 出版商
Seifert A, Zeng S, Zhang J, Kim T, Cohen N, Beckman M, et al. PD-1/PD-L1 Blockade Enhances T-cell Activity and Antitumor Efficacy of Imatinib in Gastrointestinal Stromal Tumors. Clin Cancer Res. 2017;23:454-465 pubmed 出版商
Ko E, Lee Y, Kim K, Jung Y, Lee Y, Denning T, et al. Effects of MF59 Adjuvant on Induction of Isotype-Switched IgG Antibodies and Protection after Immunization with T-Dependent Influenza Virus Vaccine in the Absence of CD4+ T Cells. J Virol. 2016;90:6976-6988 pubmed 出版商
Hermes G, Ajioka J, Kelly K, Mui E, Roberts F, Kasza K, et al. Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection. J Neuroinflammation. 2008;5:48 pubmed 出版商
Yu Q, Park J, Doan L, Erman B, Feigenbaum L, Singer A. Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection. J Exp Med. 2006;203:165-75 pubmed
Cohen J, Trenado A, Vasey D, Klatzmann D, Salomon B. CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host disease. J Exp Med. 2002;196:401-6 pubmed
Panigada M, Porcellini S, Barbier E, Hoeflinger S, Cazenave P, Gu H, et al. Constitutive endocytosis and degradation of the pre-T cell receptor. J Exp Med. 2002;195:1585-97 pubmed
Li Y, Wang M, Li H, King K, Bassi R, Sun H, et al. Active immunization against the vascular endothelial growth factor receptor flk1 inhibits tumor angiogenesis and metastasis. J Exp Med. 2002;195:1575-84 pubmed
Chung D, Chitnis T, Panzo R, Kasper D, Sayegh M, Tzianabos A. CD4+ T cells regulate surgical and postinfectious adhesion formation. J Exp Med. 2002;195:1471-8 pubmed
Yamazaki T, Takeda K, Gotoh K, Takeshima H, Akira S, Kurosaki T. Essential immunoregulatory role for BCAP in B cell development and function. J Exp Med. 2002;195:535-45 pubmed
Foucras G, Gapin L, Coureau C, Kanellopoulos J, Guery J. Interleukin 4-producing CD4 T cells arise from different precursors depending on the conditions of antigen exposure in vivo. J Exp Med. 2000;191:683-94 pubmed
产品信息
Cat.# :
553726
品牌 :
BD Pharmingen
名称 :
CD4
格式 :
NA/LE
克隆 :
GK1.5
抗体亚型 :
大鼠IgG 2b
反应 :
Ms
浓度 :
1.0毫克/毫升
Apps :
FCM
规格 :
0.5毫克
状态 :
RUO
更多信息或购买 :
公司信息
碧迪BD
上海市南京西路1168号中信泰富广场30楼
http://www.bd.com/china
021-32104610