出版应用/物种/样本/稀释 | 参考文献 |
---|
- 免疫组化-冰冻切片; 小鼠; 1:50; 图 1d
| McMahon M, Contreras A, Holm M, Uechi T, Forester C, Pang X, et al. A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS. elife. 2019;8: pubmed 出版商
|
- 免疫组化-石蜡切片; 人类; 1:50; 图 1e
- 免疫印迹; 人类; 1:1000; 图 1g
| Gal H, Lysenko M, Stroganov S, Vadai E, Youssef S, Tzadikevitch Geffen K, et al. Molecular pathways of senescence regulate placental structure and function. EMBO J. 2019;38:e100849 pubmed 出版商
|
- 免疫组化-石蜡切片; 小鼠; 1:50; 图 6c, s2d
| Hari P, Millar F, Tarrats N, Birch J, Quintanilla A, Rink C, et al. The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype. Sci Adv. 2019;5:eaaw0254 pubmed 出版商
|
| Kucab J, Zou X, Morganella S, Joel M, Nanda A, Nagy E, et al. A Compendium of Mutational Signatures of Environmental Agents. Cell. 2019;177:821-836.e16 pubmed 出版商
|
- 免疫组化-冰冻切片; 小鼠; 1:200; 图 3i
| Ritschka B, Storer M, Mas A, Heinzmann F, Ortells M, Morton J, et al. The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration. Genes Dev. 2017;31:172-183 pubmed 出版商
|
| Kucab J, Hollstein M, Arlt V, Phillips D. Nutlin-3a selects for cells harbouring TP53 mutations. Int J Cancer. 2017;140:877-887 pubmed 出版商
|
| Schlierf A, Altmann E, Quancard J, Jefferson A, Assenberg R, Renatus M, et al. Targeted inhibition of the COP9 signalosome for treatment of cancer. Nat Commun. 2016;7:13166 pubmed 出版商
|
| Hoare M, Ito Y, Kang T, Weekes M, Matheson N, Patten D, et al. NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol. 2016;18:979-92 pubmed 出版商
|
| Dutta A, Le Magnen C, Mitrofanova A, Ouyang X, Califano A, Abate Shen C. Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation. Science. 2016;352:1576-80 pubmed 出版商
|
| Chesnokova V, Zonis S, Zhou C, Recouvreux M, Ben Shlomo A, Araki T, et al. Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A. 2016;113:E3250-9 pubmed 出版商
|
- 免疫印迹; 人类; 图 1
- 免疫印迹; 小鼠; 图 1
| Yosef R, Pilpel N, Tokarsky Amiel R, Biran A, Ovadya Y, Cohen S, et al. Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL. Nat Commun. 2016;7:11190 pubmed 出版商
|
| Ardini E, Menichincheri M, Banfi P, Bosotti R, De Ponti C, Pulci R, et al. Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications. Mol Cancer Ther. 2016;15:628-39 pubmed 出版商
|
| Kucab J, Zwart E, van Steeg H, Luijten M, Schmeiser H, Phillips D, et al. TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts. DNA Repair (Amst). 2016;39:21-33 pubmed 出版商
|
| Daou S, Hammond Martel I, Mashtalir N, Barbour H, Gagnon J, Iannantuono N, et al. The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer. J Biol Chem. 2015;290:28643-63 pubmed 出版商
|
| Wang J, Hua W, Huang S, Fan K, Takeshima L, Mao Y, et al. RASSF8 regulates progression of cutaneous melanoma through nuclear factor-κb. Oncotarget. 2015;6:30165-77 pubmed 出版商
|
| Trokovic R, Weltner J, Noisa P, Raivio T, Otonkoski T. Combined negative effect of donor age and time in culture on the reprogramming efficiency into induced pluripotent stem cells. Stem Cell Res. 2015;15:254-62 pubmed 出版商
|
| Moiseeva O, Lessard F, Acevedo Aquino M, Vernier M, Tsantrizos Y, Ferbeyre G. Mutant lamin A links prophase to a p53 independent senescence program. Cell Cycle. 2015;14:2408-21 pubmed 出版商
|
| Scala F, Brighenti E, Govoni M, Imbrogno E, Fornari F, Treré D, et al. Direct relationship between the level of p53 stabilization induced by rRNA synthesis-inhibiting drugs and the cell ribosome biogenesis rate. Oncogene. 2016;35:977-89 pubmed 出版商
|
- 免疫组化-石蜡切片; 小鼠; 1:200; 图 1
| Gergics P, Brinkmeier M, Camper S. Lhx4 deficiency: increased cyclin-dependent kinase inhibitor expression and pituitary hypoplasia. Mol Endocrinol. 2015;29:597-612 pubmed 出版商
|
| Cai K, Wang Y, Smith E, Smedberg J, Yang D, Yang W, et al. Global deletion of Trp53 reverts ovarian tumor phenotype of the germ cell-deficient white spotting variant (Wv) mice. Neoplasia. 2015;17:89-100 pubmed 出版商
|
| Raouf S, Weston C, Yucel N. Registered report: senescence surveillance of pre-malignant hepatocytes limits liver cancer development. elife. 2015;4: pubmed 出版商
|
| Wohak L, Krais A, Kucab J, Stertmann J, Øvrebø S, Seidel A, et al. Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism. Arch Toxicol. 2016;90:291-304 pubmed 出版商
|
| Mungamuri S, Wang S, Manfredi J, Gu W, Aaronson S. Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters. Oncogene. 2015;34:2461-70 pubmed 出版商
|
| Ramdzan Z, Vadnais C, Pal R, Vandal G, Cadieux C, Leduy L, et al. RAS transformation requires CUX1-dependent repair of oxidative DNA damage. PLoS Biol. 2014;12:e1001807 pubmed 出版商
|
| Berkenkamp B, Susnik N, Baisantry A, Kuznetsova I, Jacobi C, Sörensen Zender I, et al. In vivo and in vitro analysis of age-associated changes and somatic cellular senescence in renal epithelial cells. PLoS ONE. 2014;9:e88071 pubmed 出版商
|
| Parsons M, McCormick L, Janke L, Howard A, Bouchier Hayes L, Green D. Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice. Cell Death Differ. 2013;20:1174-82 pubmed 出版商
|
| Strauss G, Westhoff M, Fischer Posovszky P, Fulda S, Schanbacher M, Eckhoff S, et al. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ. 2008;15:332-43 pubmed
|
| Burocziova M, Burdova K, Martinikova A, Kaspárek P, Kleiblova P, Danielsen S, et al. Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon. Cell Death Dis. 2019;10:818 pubmed 出版商
|
| Wohak L, Baranski A, Krais A, Schmeiser H, Phillips D, Arlt V. The impact of p53 function on the metabolic activation of the carcinogenic air pollutant 3-nitrobenzanthrone and its metabolites 3-aminobenzanthrone and N-hydroxy-3-aminobenzanthrone in human cells. Mutagenesis. 2018;33:311-321 pubmed 出版商
|
| Chrysanthou S, Senner C, Woods L, Fineberg E, Okkenhaug H, Burge S, et al. A Critical Role of TET1/2 Proteins in Cell-Cycle Progression of Trophoblast Stem Cells. Stem Cell Reports. 2018;10:1355-1368 pubmed 出版商
|
| Vecino R, Burguete M, Jover Mengual T, Agulla J, Bobo Jiménez V, Salom J, et al. The MDM2-p53 pathway is involved in preconditioning-induced neuronal tolerance to ischemia. Sci Rep. 2018;8:1610 pubmed 出版商
|
| Glück S, Guey B, Gulen M, Wolter K, Kang T, Schmacke N, et al. Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence. Nat Cell Biol. 2017;19:1061-1070 pubmed 出版商
|
| Du W, Hu J, Du W, Klein O. Lineage tracing of epithelial cells in developing teeth reveals two strategies for building signaling centers. J Biol Chem. 2017;292:15062-15069 pubmed 出版商
|
| Yosef R, Pilpel N, Papismadov N, Gal H, Ovadya Y, Vadai E, et al. p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling. EMBO J. 2017;36:2280-2295 pubmed 出版商
|
| Lin H, Simon P, Ysla R, Zeichner S, Brewer G, Rabson A. RNA stability regulates human T cell leukemia virus type 1 gene expression in chronically-infected CD4 T cells. Virology. 2017;508:7-17 pubmed 出版商
|
| Hoppe Seyler K, Bossler F, Lohrey C, Bulkescher J, Rösl F, Jansen L, et al. Induction of dormancy in hypoxic human papillomavirus-positive cancer cells. Proc Natl Acad Sci U S A. 2017;114:E990-E998 pubmed 出版商
|
| Münst B, Thier M, Winnemöller D, Helfen M, Thummer R, Edenhofer F. Nanog induces suppression of senescence through downregulation of p27KIP1 expression. J Cell Sci. 2016;129:912-20 pubmed 出版商
|
| Morrissy A, Garzia L, Shih D, Zuyderduyn S, Huang X, Skowron P, et al. Divergent clonal selection dominates medulloblastoma at recurrence. Nature. 2016;529:351-7 pubmed 出版商
|
| Aguilar A, Sun W, Liu L, Lu J, McEachern D, Bernard D, et al. Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannich ring-opening-cyclization reaction mechanism in spiro-oxindoles. J Med Chem. 2014;57:10486-98 pubmed 出版商
|
| Duarte L, Young A, Wang Z, Wu H, Panda T, Kou Y, et al. Histone H3.3 and its proteolytically processed form drive a cellular senescence programme. Nat Commun. 2014;5:5210 pubmed 出版商
|
| Krais A, Mühlbauer K, Kucab J, Chinbuah H, Cornelius M, Wei Q, et al. Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts. Toxicol In Vitro. 2015;29:34-43 pubmed 出版商
|
| Tran D, Bergholz J, Zhang H, He H, Wang Y, Zhang Y, et al. Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence. Aging Cell. 2014;13:669-78 pubmed 出版商
|
| Wu J, Liang S, Bergholz J, He H, Walsh E, Zhang Y, et al. ?Np63? activates CD82 metastasis suppressor to inhibit cancer cell invasion. Cell Death Dis. 2014;5:e1280 pubmed 出版商
|
| Bohanon F, Wang X, Ding C, Ding Y, Radhakrishnan G, Rastellini C, et al. Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis. J Surg Res. 2014;190:55-63 pubmed 出版商
|
| Cassol C, Winer D, Liu W, Guo M, Ezzat S, Asa S. Tyrosine kinase receptors as molecular targets in pheochromocytomas and paragangliomas. Mod Pathol. 2014;27:1050-62 pubmed 出版商
|
| Benson E, Mungamuri S, Attie O, Kracikova M, Sachidanandam R, Manfredi J, et al. p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes. Oncogene. 2014;33:3959-69 pubmed 出版商
|
| Botchkina G, Zuniga E, Rowehl R, Park R, Bhalla R, Bialkowska A, et al. Prostate cancer stem cell-targeted efficacy of a new-generation taxoid, SBT-1214 and novel polyenolic zinc-binding curcuminoid, CMC2.24. PLoS ONE. 2013;8:e69884 pubmed 出版商
|
| El Karim E, Hagos E, Ghaleb A, Yu B, Yang V. Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts. Mol Cancer. 2013;12:89 pubmed 出版商
|
| Hazawa M, Yasuda T, Noshiro K, Saotome Nakamura A, Fukuzaki T, Michikawa Y, et al. Vitronectin improves cell survival after radiation injury in human umbilical vein endothelial cells. FEBS Open Bio. 2012;2:334-8 pubmed 出版商
|
| Al Dhaheri Y, Eid A, Abuqamar S, Attoub S, Khasawneh M, Aiche G, et al. Mitotic arrest and apoptosis in breast cancer cells induced by Origanum majorana extract: upregulation of TNF-? and downregulation of survivin and mutant p53. PLoS ONE. 2013;8:e56649 pubmed 出版商
|
| Loponen H, Ylikoski J, Albrecht J, Pirvola U. Restrictions in cell cycle progression of adult vestibular supporting cells in response to ectopic cyclin D1 expression. PLoS ONE. 2011;6:e27360 pubmed 出版商
|
| Braun F, Bertin Ciftci J, Gallouet A, Millour J, Juin P. Serum-nutrient starvation induces cell death mediated by Bax and Puma that is counteracted by p21 and unmasked by Bcl-x(L) inhibition. PLoS ONE. 2011;6:e23577 pubmed 出版商
|
| Viarisio D, Mueller Decker K, Kloz U, Aengeneyndt B, Kopp Schneider A, Grone H, et al. E6 and E7 from beta HPV38 cooperate with ultraviolet light in the development of actinic keratosis-like lesions and squamous cell carcinoma in mice. PLoS Pathog. 2011;7:e1002125 pubmed 出版商
|
| Hamouchene H, Arlt V, Giddings I, Phillips D. Influence of cell cycle on responses of MCF-7 cells to benzo[a]pyrene. BMC Genomics. 2011;12:333 pubmed 出版商
|
| Kovacic J, Gupta R, Lee A, Ma M, Fang F, Tolbert C, et al. Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice. J Clin Invest. 2010;120:303-14 pubmed 出版商
|
| Bossuyt W, Kazanjian A, De Geest N, Van Kelst S, De Hertogh G, Geboes K, et al. Atonal homolog 1 is a tumor suppressor gene. PLoS Biol. 2009;7:e39 pubmed 出版商
|
| Rousseau E, Kojima R, Hoffner G, Djian P, Bertolotti A. Misfolding of proteins with a polyglutamine expansion is facilitated by proteasomal chaperones. J Biol Chem. 2009;284:1917-29 pubmed 出版商
|