产品简要
公司名称 :
碧迪BD
其他品牌 :
Transduction Laboratories, PharMingen, Difco
产品类型 :
抗体
产品名称 :
Synuclein
目录 :
610786
规格 :
50微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
42/?-Synuclein
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 其他, 免疫印迹基因敲除验证, 免疫组化基因敲除验证, 免疫细胞化学基因敲除验证
更多信息或购买 :
文章摘录数: 54
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 大鼠; 图 2b
  • 免疫细胞化学; 人类; 图 2a
Ha T, Choi Y, Noh H, Cha S, Kim J, Park S. Age-related increase in caveolin-1 expression facilitates cell-to-cell transmission of α-synuclein in neurons. Mol Brain. 2021;14:122 pubmed 出版商
  • 免疫印迹; 人类; 图 s1h
Kara E, Crimi A, Wiedmer A, Emmenegger M, Manzoni C, Bandrés Ciga S, et al. An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein. Cell Rep. 2021;35:109189 pubmed 出版商
  • 免疫组化; 小鼠; 1:5000; 图 s2a
Polinski N, Martinez T, Gorodinsky A, Gareus R, Sasner M, Herberth M, et al. Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model. PLoS ONE. 2021;16:e0252325 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2a
Boutros S, Raber J, Unni V. Effects of Alpha-Synuclein Targeted Antisense Oligonucleotides on Lewy Body-Like Pathology and Behavioral Disturbances Induced by Injections of Pre-Formed Fibrils in the Mouse Motor Cortex. J Parkinsons Dis. 2021;11:1091-1115 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 5a
Grochowska M, Carreras Mascaro A, Boumeester V, Natale D, Breedveld G, Geut H, et al. LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson's disease and dementia with Lewy bodies. Acta Neuropathol. 2021;142:117-137 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:100; 图 1b
Fujita H, Kodama T, du Lac S. Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis. elife. 2020;9: pubmed 出版商
  • 免疫细胞化学; 人类; 1:250; 图 3f
  • 免疫印迹; 人类; 1:1000; 图 1b
Bozic M, Caus M, Rodrigues Díez R, Pedraza N, Ruiz Ortega M, Garí E, et al. Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis. Nat Commun. 2020;11:1943 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1
Ninkina N, Tarasova T, Chaprov K, Roman A, Kukharsky M, Kolik L, et al. Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice. Neurobiol Aging. 2020;91:76-87 pubmed 出版商
  • 免疫组化; 人类; 1:2000; 表 1
Yilmazer Hanke D, Mayer T, Müller H, Neugebauer H, Abaei A, Scheuerle A, et al. Histological correlates of postmortem ultra-high-resolution single-section MRI in cortical cerebral microinfarcts. Acta Neuropathol Commun. 2020;8:33 pubmed 出版商
  • 免疫细胞化学基因敲除验证; 人类; 1:500; 图 2a
  • 免疫印迹基因敲除验证; 人类; 图 2b1
Schaser A, Osterberg V, Dent S, Stackhouse T, Wakeham C, Boutros S, et al. Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders. Sci Rep. 2019;9:10919 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 1:1000; 图 7c
Carballo Carbajal I, Laguna A, Romero Gimenez J, Cuadros T, Bove J, Martinez Vicente M, et al. Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis. Nat Commun. 2019;10:973 pubmed 出版商
  • 免疫印迹; 人类; 图 5e
Fanning S, Haque A, Imberdis T, Baru V, Barrasa M, Nuber S, et al. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Mol Cell. 2019;73:1001-1014.e8 pubmed 出版商
  • 免疫沉淀; 小鼠; 图 3d
  • 免疫印迹; 小鼠; 图 3d
Deng Y, Jiang B, Rankin C, Toyo oka K, Richter M, Maupin Furlow J, et al. Methionine sulfoxide reductase A (MsrA) mediates the ubiquitination of 14-3-3 protein isotypes in brain. Free Radic Biol Med. 2018;129:600-607 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 7
Delic V, Chandra S, Abdelmotilib H, Maltbie T, Wang S, Kem D, et al. Sensitivity and specificity of phospho-Ser129 ?-synuclein monoclonal antibodies. J Comp Neurol. 2018;526:1978-1990 pubmed 出版商
  • 其他; 人类; 图 1a, 1b
  • 免疫印迹; 人类; 图 s2, s4, s5
Je G, Croop B, Basu S, Tang J, Han K, Kim Y. Endogenous Alpha-Synuclein Protein Analysis from Human Brain Tissues Using Single-Molecule Pull-Down Assay. Anal Chem. 2017;89:13044-13048 pubmed 出版商
  • 免疫印迹; 人类; 图 3e
Takahashi Y, Wu J, Suzuki K, Martínez Redondo P, Li M, Liao H, et al. Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells. Science. 2017;356:503-508 pubmed 出版商
  • 免疫印迹; 小鼠; 表 1
Cao M, Wu Y, Ashrafi G, McCartney A, Wheeler H, Bushong E, et al. Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons. Neuron. 2017;93:882-896.e5 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:500; 图 5c
  • 免疫印迹; 大鼠; 1:500; 图 5e
Menges S, Minakaki G, Schaefer P, Meixner H, Prots I, Schlötzer Schrehardt U, et al. Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress. Sci Rep. 2017;7:42942 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:300; 图 2c
Ettle B, Kuhbandner K, Jörg S, Hoffmann A, Winkler J, Linker R. α-Synuclein deficiency promotes neuroinflammation by increasing Th1 cell-mediated immune responses. J Neuroinflammation. 2016;13:201 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 5
  • 免疫组化基因敲除验证; 小鼠; 图 1
  • 免疫印迹基因敲除验证; 小鼠; 1:2000; 图 2
Baksi S, Tripathi A, Singh N. Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease. Free Radic Biol Med. 2016;97:292-306 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 4a
Barca E, Kleiner G, Tang G, Ziosi M, Tadesse S, Masliah E, et al. Decreased Coenzyme Q10 Levels in Multiple System Atrophy Cerebellum. J Neuropathol Exp Neurol. 2016;75:663-72 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 2
Kaufmann T, Harrison P, Richardson M, Pinheiro T, Wall M. Intracellular soluble α-synuclein oligomers reduce pyramidal cell excitability. J Physiol. 2016;594:2751-72 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:1000; 图 3
Ninkina N, Connor Robson N, Ustyugov A, Tarasova T, Shelkovnikova T, Buchman V. A novel resource for studying function and dysfunction of α-synuclein: mouse lines for modulation of endogenous Snca gene expression. Sci Rep. 2015;5:16615 pubmed 出版商
  • 免疫细胞化学; 人类; 图 7
  • 免疫印迹; 人类; 图 4
Xiong R, Zhou W, Siegel D, Kitson R, Freed C, Moody C, et al. A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity. Mol Pharmacol. 2015;88:1045-54 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:500
Kett L, Stiller B, Bernath M, Tasset I, Blesa J, Jackson Lewis V, et al. α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2. J Neurosci. 2015;35:5724-42 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Gispert S, Kurz A, Brehm N, Rau K, Walter M, Riess O, et al. Complexin-1 and Foxp1 Expression Changes Are Novel Brain Effects of Alpha-Synuclein Pathology. Mol Neurobiol. 2015;52:57-63 pubmed 出版商
  • 免疫组化-冰冻切片; 大鼠; 1:1000
  • 免疫印迹; 大鼠; 1:1000
Aldrin Kirk P, Davidsson M, Holmqvist S, Li J, Bjorklund T. Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons. PLoS ONE. 2014;9:e100869 pubmed 出版商
  • 免疫印迹; 小鼠
Tsika E, Glauser L, Moser R, Fiser A, Daniel G, Sheerin U, et al. Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration. Hum Mol Genet. 2014;23:4621-38 pubmed 出版商
  • 免疫印迹; 大鼠; 图 4a
Fan X, Jin W, Lu J, Wang J, Wang Y. Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation. Nat Neurosci. 2014;17:471-80 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5
Smith B, Santos M, Marshall M, Cantuti Castelvetri L, Lopez Rosas A, Li G, et al. Neuronal inclusions of ?-synuclein contribute to the pathogenesis of Krabbe disease. J Pathol. 2014;232:509-21 pubmed 出版商
  • 免疫印迹; 大鼠
Diao J, Burré J, Vivona S, Cipriano D, Sharma M, Kyoung M, et al. Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2. elife. 2013;2:e00592 pubmed 出版商
  • 免疫印迹; 大鼠; 1:2000
Scarr E, Dean B. Altered neuronal markers following treatment with mood stabilizer and antipsychotic drugs indicate an increased likelihood of neurotransmitter release. Clin Psychopharmacol Neurosci. 2012;10:25-33 pubmed 出版商
  • 免疫印迹; 人类
Burré J, Sharma M, Tsetsenis T, Buchman V, Etherton M, Südhof T. Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science. 2010;329:1663-7 pubmed 出版商
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
Martin L, Liu Z, Chen K, Price A, Pan Y, Swaby J, et al. Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death. J Comp Neurol. 2007;500:20-46 pubmed
Brekk O, Korecka J, Crapart C, Huebecker M, MacBain Z, Rosenthal S, et al. Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity. Acta Neuropathol Commun. 2020;8:127 pubmed 出版商
Yang X, Williams J, Yan R, Mouradian M, Baum J. Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity. Sci Rep. 2019;9:17579 pubmed 出版商
Yuan N, Cai C, Wu M, Zhu Q, Su H, Li M, et al. Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology. Front Pharmacol. 2019;10:16 pubmed 出版商
Abdelkarim H, Marshall M, Scesa G, Smith R, Rue E, Marshall J, et al. ?-Synuclein interacts directly but reversibly with psychosine: implications for ?-synucleinopathies. Sci Rep. 2018;8:12462 pubmed 出版商
Beauchamp L, Chan J, Hung L, Padman B, Vella L, Liu X, et al. Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease. Acta Neuropathol Commun. 2018;6:57 pubmed 出版商
Choi D, Yoo M, Kabaria S, Junn E. MicroRNA-7 facilitates the degradation of alpha-synuclein and its aggregates by promoting autophagy. Neurosci Lett. 2018;678:118-123 pubmed 出版商
Wang L, Hong J, Wu Y, Liu G, Yu W, Chen L. Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of ?-synuclein and neuroinflammation. Cell Death Dis. 2018;9:440 pubmed 出版商
Recasens A, Carballo Carbajal I, Parent A, Bove J, Gelpi E, Tolosa E, et al. Lack of pathogenic potential of peripheral ?-synuclein aggregates from Parkinson's disease patients. Acta Neuropathol Commun. 2018;6:8 pubmed 出版商
Íñigo Marco I, Valencia M, Larrea L, Bugallo R, Martínez Goikoetxea M, Zuriguel I, et al. E46K ?-synuclein pathological mutation causes cell-autonomous toxicity without altering protein turnover or aggregation. Proc Natl Acad Sci U S A. 2017;114:E8274-E8283 pubmed 出版商
Taguchi Y, Liu J, Ruan J, Pacheco J, Zhang X, Abbasi J, et al. Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease. J Neurosci. 2017;37:9617-9631 pubmed 出版商
Latina V, Caioli S, Zona C, Ciotti M, Amadoro G, Calissano P. Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons. Front Cell Neurosci. 2017;11:68 pubmed 出版商
Koch J, Bitow F, Haack J, D Hedouville Z, Zhang J, Tönges L, et al. Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons. Cell Death Dis. 2015;6:e1811 pubmed 出版商
Doorn K, Moors T, Drukarch B, van de Berg W, Lucassen P, van Dam A. Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients. Acta Neuropathol Commun. 2014;2:90 pubmed 出版商
Inoue K, Rispoli J, Kaphzan H, Klann E, Chen E, Kim J, et al. Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Mol Neurodegener. 2012;7:48 pubmed 出版商
Maarouf C, Daugs I, Kokjohn T, Walker D, Hunter J, Kruchowsky J, et al. Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging. PLoS ONE. 2011;6:e27291 pubmed 出版商
Martins M, Rosa A, Guedes L, Fonseca B, Gotovac K, Violante S, et al. Convergence of miRNA expression profiling, ?-synuclein interacton and GWAS in Parkinson's disease. PLoS ONE. 2011;6:e25443 pubmed 出版商
Vernon A, Crum W, Johansson S, Modo M. Evolution of extra-nigral damage predicts behavioural deficits in a rat proteasome inhibitor model of Parkinson's disease. PLoS ONE. 2011;6:e17269 pubmed 出版商
Thayanidhi N, Helm J, Nycz D, Bentley M, Liang Y, Hay J. Alpha-synuclein delays endoplasmic reticulum (ER)-to-Golgi transport in mammalian cells by antagonizing ER/Golgi SNAREs. Mol Biol Cell. 2010;21:1850-63 pubmed 出版商
Lou H, Montoya S, Alerte T, Wang J, Wu J, Peng X, et al. Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo. J Biol Chem. 2010;285:17648-61 pubmed 出版商
Vernon A, Johansson S, Modo M. Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson's disease. BMC Neurosci. 2010;11:1 pubmed 出版商
产品信息
Cat.# :
610786
品牌 :
BD Transduction Laboratories
名称 :
Synuclein
格式 :
纯化
克隆 :
42/α-Synuclein
抗体亚型 :
Ms IgG 1
反应 :
Hu , Ms , Rat
浓度 :
250微克/毫升
Apps :
IF, 免疫印迹
规格 :
50微克
状态 :
RUO
更多信息或购买 :
公司信息
碧迪BD
上海市南京西路1168号中信泰富广场30楼
http://www.bd.com/china
021-32104610