产品简要
公司名称 :
碧迪BD
其他品牌 :
Transduction Laboratories, PharMingen, Difco
产品类型 :
抗体
产品名称 :
HIF-1
目录 :
610959
规格 :
150微克
价格 :
415.00美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
54/HIF-1
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, ChIP-Seq, 其他
更多信息或购买 :
文章摘录数: 74
出版应用/物种/样品/稀释参考文献
  • 免疫细胞化学; 人类; 1:100; 图 5A
  • 免疫印迹; 人类; 1:1000; 图 1E
Miles A, Burr S, Grice G, Nathan J. The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1? prolyl hydroxylation by regulating cellular iron levels. elife. 2017;6: pubmed 出版商
  • 免疫印迹; 人类; 图 3b
Li J, Yakushi T, Parlati F, MacKinnon A, Pérez C, Ma Y, et al. Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol. 2017;13:486-493 pubmed 出版商
  • 免疫印迹; 人类; 图 2f
Kozlova N, Wottawa M, Katschinski D, Kristiansen G, Kietzmann T. Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer. Oncotarget. 2017;8:9885-9898 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Fulcher L, MacArtney T, Bozatzi P, Hornberger A, Rojas Fernandez A, Sapkota G. An affinity-directed protein missile system for targeted proteolysis. Open Biol. 2016;6: pubmed
  • 免疫印迹; 人类; 图 s2a
Pradhan S, Mahajan D, Kaur P, Pandey N, Sharma C, Srivastava T. Scriptaid overcomes hypoxia-induced cisplatin resistance in both wild-type and mutant p53 lung cancer cells. Oncotarget. 2016;7:71841-71855 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Masola V, Zaza G, Gambaro G, Onisto M, Bellin G, Vischini G, et al. Heparanase: A Potential New Factor Involved in the Renal Epithelial Mesenchymal Transition (EMT) Induced by Ischemia/Reperfusion (I/R) Injury. PLoS ONE. 2016;11:e0160074 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s11a
Bigot P, Colli L, Machiela M, Jessop L, Myers T, Carrouget J, et al. Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41. Nat Commun. 2016;7:12098 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3a
Mandl M, Lieberum M, Depping R. A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT. Cell Death Dis. 2016;7:e2284 pubmed 出版商
  • 免疫印迹; 人类; 图 4e
Salvi V, Vermi W, Gianello V, Lonardi S, Gagliostro V, Naldini A, et al. Dendritic cell-derived VEGF-A plays a role in inflammatory angiogenesis of human secondary lymphoid organs and is driven by the coordinated activation of multiple transcription factors. Oncotarget. 2016;7:39256-39269 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Lim S, Liu H, Madeira da Silva L, Arora R, Liu Z, Phillips J, et al. Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1?. Cancer Res. 2016;76:2231-42 pubmed 出版商
  • 其他; 人类; 图 st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Dai X, Zhuang L, Wang D, Zhou T, Chang L, Gai R, et al. Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells. Oncotarget. 2016;7:6933-47 pubmed 出版商
  • 免疫印迹; 人类; 图 4c
Azoitei N, Becher A, Steinestel K, Rouhi A, Diepold K, Genze F, et al. PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation. Mol Cancer. 2016;15:3 pubmed 出版商
  • 免疫印迹; 人类; 图  s1
de Bruin A, A Cornelissen P, Kirchmaier B, Mokry M, Iich E, Nirmala E, et al. Genome-wide analysis reveals NRP1 as a direct HIF1?-E2F7 target in the regulation of motorneuron guidance in vivo. Nucleic Acids Res. 2016;44:3549-66 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 2b
Weijer R, Broekgaarden M, Krekorian M, Alles L, van Wijk A, Mackaaij C, et al. Inhibition of hypoxia inducible factor 1 and topoisomerase with acriflavine sensitizes perihilar cholangiocarcinomas to photodynamic therapy. Oncotarget. 2016;7:3341-56 pubmed 出版商
  • 免疫印迹; 人类; 图 s10b
Bowser J, Blackburn M, Shipley G, Molina J, Dunner K, Broaddus R. Loss of CD73-mediated actin polymerization promotes endometrial tumor progression. J Clin Invest. 2016;126:220-38 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Adam M, Matt S, Christian S, Hess Stumpp H, Haegebarth A, Hofmann T, et al. SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status. Cell Cycle. 2015;14:3734-47 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2a
Mandl M, Lieberum M, Dunst J, Depping R. The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment. Radiat Oncol. 2015;10:229 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 9C
Konzack A, Jakupovic M, Kubaichuk K, Görlach A, Dombrowski F, Miinalainen I, et al. Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis. Antioxid Redox Signal. 2015;23:1059-75 pubmed 出版商
  • 免疫印迹; 人类; 图 3c
Högel H, Miikkulainen P, Bino L, Jaakkola P. Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27. Mol Cancer. 2015;14:143 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Lin A, Abbas S, Kim S, Ortega M, Bouamar H, Escobedo Y, et al. D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2. Nat Commun. 2015;6:7768 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Cimmino F, Pezone L, Avitabile M, Acierno G, Andolfo I, Capasso M, et al. Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells. Sci Rep. 2015;5:11158 pubmed 出版商
  • 免疫印迹; 人类; 1:250; 图 6a
Sotoodehnejadnematalahi F, Staples K, Chrysanthou E, Pearson H, Ziegler Heitbrock L, Burke B. Mechanisms of Hypoxic Up-Regulation of Versican Gene Expression in Macrophages. PLoS ONE. 2015;10:e0125799 pubmed 出版商
  • 免疫印迹; 人类; 图 1b
Choi H, Gillespie D, Berg S, Rice C, Couldwell S, Gu J, et al. Intermittent induction of HIF-1α produces lasting effects on malignant progression independent of its continued expression. PLoS ONE. 2015;10:e0125125 pubmed 出版商
  • 免疫沉淀; 人类; 图 1d
Alig S, Stampnik Y, Pircher J, Rotter R, Gaitzsch E, Ribeiro A, et al. The tyrosine phosphatase SHP-1 regulates hypoxia inducible factor-1α (HIF-1α) protein levels in endothelial cells under hypoxia. PLoS ONE. 2015;10:e0121113 pubmed 出版商
  • 免疫印迹; 人类; 图 s4
Staudacher J, Naarmann de Vries I, Ujvari S, Klinger B, Kasim M, Benko E, et al. Hypoxia-induced gene expression results from selective mRNA partitioning to the endoplasmic reticulum. Nucleic Acids Res. 2015;43:3219-36 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5,6
Hsiao H, Hsu T, Liu W, Hsieh W, Chou T, Wu Y, et al. Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo. Nat Commun. 2015;6:6353 pubmed 出版商
  • 免疫印迹; 人类; 1:500
He Z, Li B, Rankin G, Rojanasakul Y, Chen Y. Selecting bioactive phenolic compounds as potential agents to inhibit proliferation and VEGF expression in human ovarian cancer cells. Oncol Lett. 2015;9:1444-1450 pubmed
  • 免疫印迹; 人类
Singleton D, Rouhi P, Zois C, Haider S, Li J, Kessler B, et al. Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis. Oncogene. 2015;34:4713-22 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6
Olayanju A, Copple I, Bryan H, Edge G, Sison R, Wong M, et al. Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2. Free Radic Biol Med. 2015;78:202-12 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4
Lei Q, Qiang F, Chao D, Di W, Guoqian Z, Bo Y, et al. Amelioration of hypoxia and LPS-induced intestinal epithelial barrier dysfunction by emodin through the suppression of the NF-κB and HIF-1α signaling pathways. Int J Mol Med. 2014;34:1629-39 pubmed 出版商
  • 免疫印迹; 人类
Sena J, Wang L, Pawlus M, Hu C. HIFs enhance the transcriptional activation and splicing of adrenomedullin. Mol Cancer Res. 2014;12:728-41 pubmed 出版商
  • 免疫印迹; 人类
Avena P, Anselmo W, Whitaker Menezes D, Wang C, Pestell R, Lamb R, et al. Compartment-specific activation of PPAR? governs breast cancer tumor growth, via metabolic reprogramming and symbiosis. Cell Cycle. 2013;12:1360-70 pubmed 出版商
  • ChIP-Seq; 人类
  • 免疫印迹; 人类
Wu C, Tang S, Wang P, Lee H, Ko J. Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation. J Biol Chem. 2012;287:25292-302 pubmed 出版商
  • 免疫印迹; 人类
Chew E, Hagen T. Substrate-mediated regulation of cullin neddylation. J Biol Chem. 2007;282:17032-40 pubmed
Navarrete C, Carrillo Salinas F, Palomares B, Mecha M, Jiménez Jiménez C, Mestre L, et al. Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy. J Neuroinflammation. 2018;15:64 pubmed 出版商
Yao X, Tan J, Lim K, Koh J, Ooi W, Li Z, et al. VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma. Cancer Discov. 2017;7:1284-1305 pubmed 出版商
Voss D, Spina R, Carter D, Lim K, Jeffery C, Bar E. Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression. Sci Rep. 2017;7:4292 pubmed 出版商
Azimi I, Milevskiy M, Kaemmerer E, Turner D, Yapa K, Brown M, et al. TRPC1 is a differential regulator of hypoxia-mediated events and Akt signalling in PTEN-deficient breast cancer cells. J Cell Sci. 2017;130:2292-2305 pubmed 出版商
Takada M, Zhuang M, Inuzuka H, Zhang J, Zurlo G, Zhang J, et al. EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the FBW7 tumor suppressor. Oncotarget. 2017;8:6787-6795 pubmed 出版商
Thompson J, Nguyen Q, Singh M, Pavesic M, Nesterenko I, Nelson L, et al. Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma. Oncogene. 2017;36:1080-1089 pubmed 出版商
Chen T, Zhou Q, Tang H, Bozkanat M, Yuan J, Raj J, et al. miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation. J Am Heart Assoc. 2016;5: pubmed
Taylor S, Bagnall J, Mason D, Levy R, Fernig D, See V. Differential sub-nuclear distribution of hypoxia-inducible factors (HIF)-1 and -2 alpha impacts on their stability and mobility. Open Biol. 2016;6: pubmed
Wu Y, Meitzler J, Antony S, Juhasz A, Lu J, Jiang G, et al. Dual oxidase 2 and pancreatic adenocarcinoma: IFN-γ-mediated dual oxidase 2 overexpression results in H2O2-induced, ERK-associated up-regulation of HIF-1α and VEGF-A. Oncotarget. 2016;7:68412-68433 pubmed 出版商
de Wit R, Mujić Delić A, van Senten J, Fraile Ramos A, Siderius M, Smit M. Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1α/PKM2 axis in glioblastoma cells. Oncotarget. 2016;7:67966-67985 pubmed 出版商
Zhang C, Zhi W, Lu H, Samanta D, Chen I, Gabrielson E, et al. Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells. Oncotarget. 2016;7:64527-64542 pubmed 出版商
Yeom C, Zeng L, Goto Y, Morinibu A, Zhu Y, Shinomiya K, et al. LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis. Oncotarget. 2016;7:65837-65848 pubmed 出版商
Jou Y, Tsai Y, Lin C, Tung C, Shen C, Tsai H, et al. Foxp3 enhances HIF-1α target gene expression in human bladder cancer through decreasing its ubiquitin-proteasomal degradation. Oncotarget. 2016;7:65403-65417 pubmed 出版商
Simko V, Takacova M, Debreova M, Laposova K, Ondriskova Panisova E, Pastorekova S, et al. Dexamethasone downregulates expression of carbonic anhydrase IX via HIF-1? and NF-?B-dependent mechanisms. Int J Oncol. 2016;49:1277-88 pubmed 出版商
Ma J, Mi C, Wang K, Lee J, Jin X. Zinc finger protein 91 (ZFP91) activates HIF-1? via NF-?B/p65 to promote proliferation and tumorigenesis of colon cancer. Oncotarget. 2016;7:36551-36562 pubmed 出版商
Richards R, Jenkinson M, Haylock B, See V. Cell cycle progression in glioblastoma cells is unaffected by pathophysiological levels of hypoxia. Peerj. 2016;4:e1755 pubmed 出版商
Davies E, Dong M, Gutekunst M, Närhi K, van Zoggel H, Blom S, et al. Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices. Sci Rep. 2015;5:17187 pubmed 出版商
Sato M, Hirose K, Kashiwakura I, Aoki M, Kawaguchi H, Hatayama Y, et al. LW6, a hypoxia-inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells. Mol Med Rep. 2015;12:3462-3468 pubmed 出版商
Chen R, Xu M, Nagati J, Hogg R, Das A, Gerard R, et al. The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment. PLoS ONE. 2015;10:e0116515 pubmed 出版商
Asnaghi L, Lin M, Lim K, Lim K, Tripathy A, Wendeborn M, et al. Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation. PLoS ONE. 2014;9:e105372 pubmed 出版商
Hunter B, Eustace A, Irlam J, Valentine H, Denley H, Oguejiofor K, et al. Expression of hypoxia-inducible factor-1? predicts benefit from hypoxia modification in invasive bladder cancer. Br J Cancer. 2014;111:437-43 pubmed 出版商
Poulsen R, Knowles H, Carr A, Hulley P. Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposure. Cell Death Dis. 2014;5:e1074 pubmed 出版商
Camps C, Saini H, Mole D, Choudhry H, Reczko M, Guerra Assunção J, et al. Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia. Mol Cancer. 2014;13:28 pubmed 出版商
Kazi A, Gilani R, Schech A, Chumsri S, Sabnis G, Shah P, et al. Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer. Breast Cancer Res. 2014;16:R15 pubmed 出版商
Bagnall J, Leedale J, Taylor S, Spiller D, White M, Sharkey K, et al. Tight control of hypoxia-inducible factor-? transient dynamics is essential for cell survival in hypoxia. J Biol Chem. 2014;289:5549-64 pubmed 出版商
Liu X, Cai T, Zhu H, Cao J, Su Y, Hu Y, et al. Q6, a novel hypoxia-targeted drug, regulates hypoxia-inducible factor signaling via an autophagy-dependent mechanism in hepatocellular carcinoma. Autophagy. 2014;10:111-22 pubmed 出版商
Lai D, Tan C, Gunaratne J, Quek L, Nei W, Thierry F, et al. Localization of HPV-18 E2 at mitochondrial membranes induces ROS release and modulates host cell metabolism. PLoS ONE. 2013;8:e75625 pubmed 出版商
Yentrapalli R, Azimzadeh O, Sriharshan A, Malinowsky K, Merl J, Wojcik A, et al. The PI3K/Akt/mTOR pathway is implicated in the premature senescence of primary human endothelial cells exposed to chronic radiation. PLoS ONE. 2013;8:e70024 pubmed 出版商
Tan C, Hagen T. mTORC1 dependent regulation of REDD1 protein stability. PLoS ONE. 2013;8:e63970 pubmed 出版商
Chen J, Li Z, Chen A, Ye X, Luo H, Rankin G, et al. Inhibitory effect of baicalin and baicalein on ovarian cancer cells. Int J Mol Sci. 2013;14:6012-25 pubmed 出版商
Kelly C, Glover L, Campbell E, Kominsky D, Ehrentraut S, Bowers B, et al. Fundamental role for HIF-1? in constitutive expression of human ? defensin-1. Mucosal Immunol. 2013;6:1110-8 pubmed 出版商
Capparelli C, Whitaker Menezes D, Guido C, Balliet R, Pestell T, Howell A, et al. CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth. Cell Cycle. 2012;11:2272-84 pubmed 出版商
Doublier S, Belisario D, Polimeni M, Annaratone L, Riganti C, Allia E, et al. HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast. BMC Cancer. 2012;12:4 pubmed 出版商
Högel H, Rantanen K, Jokilehto T, Grenman R, Jaakkola P. Prolyl hydroxylase PHD3 enhances the hypoxic survival and G1 to S transition of carcinoma cells. PLoS ONE. 2011;6:e27112 pubmed 出版商
Wollenick K, Hu J, Kristiansen G, Schraml P, Rehrauer H, Berchner Pfannschmidt U, et al. Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling. Nucleic Acids Res. 2012;40:1928-43 pubmed 出版商
Chen A, Kleiboeker S, Qiu J. Productive parvovirus B19 infection of primary human erythroid progenitor cells at hypoxia is regulated by STAT5A and MEK signaling but not HIF?. PLoS Pathog. 2011;7:e1002088 pubmed 出版商
Pascal L, Ai J, Rigatti L, Lipton A, Xiao W, Gnarra J, et al. EAF2 loss enhances angiogenic effects of Von Hippel-Lindau heterozygosity on the murine liver and prostate. Angiogenesis. 2011;14:331-43 pubmed 出版商
Brockmeier U, Platzek C, Schneider K, Patak P, Bernardini A, Fandrey J, et al. The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9. PLoS ONE. 2011;6:e19151 pubmed 出版商
Bluff J, Menakuru S, Cross S, Higham S, Balasubramanian S, Brown N, et al. Angiogenesis is associated with the onset of hyperplasia in human ductal breast disease. Br J Cancer. 2009;101:666-72 pubmed 出版商
产品信息
Cat.# :
610959
品牌 :
BD Transduction Laboratories
名称 :
HIF-1
格式 :
纯化
克隆 :
54/HIF-1
抗体亚型 :
Ms IgG 1
反应 :
Hu
浓度 :
250微克/毫升
Apps :
IF, 免疫印迹
规格 :
150微克
状态 :
RUO
标价 :
415.00美元
更多信息或购买 :
公司信息
碧迪BD
上海市南京西路1168号中信泰富广场30楼
www.bd.com/china
021-32104610