产品简要
公司名称 :
Badrilla
产品类型 :
抗体
产品名称 :
Phospholamban Phospho Serine-16
目录 :
A010-12
规格 :
20微升
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹
更多信息或购买 :
Badrilla 产品网页
文章摘录数: 9
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 3d
Neumann J, Grobe J, Weisgut J, Schwelberger H, Fogel W, Marusakova M, et al. Histamine can be Formed and Degraded in the Human and Mouse Heart. Front Pharmacol. 2021;12:582916 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 5a
Dai W, Laforest B, Tyan L, Shen K, Nadadur R, Alvarado F, et al. A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 大鼠; 1:5000; 图 2c
Scotcher J, Prysyazhna O, Boguslavskyi A, Kistamás K, Hadgraft N, Martin E, et al. Disulfide-activated protein kinase G I? regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response. Nat Commun. 2016;7:13187 pubmed 出版商
  • 免疫印迹; 大鼠; 1:5000; 图 s1
Sadredini M, Danielsen T, Aronsen J, Manotheepan R, Hougen K, Sjaastad I, et al. Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure. PLoS ONE. 2016;11:e0153887 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7d
Mederle K, Gess B, Pluteanu F, Plackic J, Tiefenbach K, Grill A, et al. The angiotensin receptor-associated protein Atrap is a stimulator of the cardiac Ca2+-ATPase SERCA2a. Cardiovasc Res. 2016;110:359-70 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, et al. Heterozygous deletion of sarcolipin maintains normal cardiac function. Am J Physiol Heart Circ Physiol. 2016;310:H92-103 pubmed 出版商
Subramanian H, Froese A, Jonsson P, Schmidt H, Gorelik J, Nikolaev V. Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP. Nat Commun. 2018;9:2446 pubmed 出版商
Kusakari Y, Urashima T, Shimura D, Amemiya E, Miyasaka G, Yokota S, et al. Impairment of Excitation-Contraction Coupling in Right Ventricular Hypertrophied Muscle with Fibrosis Induced by Pulmonary Artery Banding. PLoS ONE. 2017;12:e0169564 pubmed 出版商
Helms A, Alvarado F, Yob J, Tang V, Pagani F, Russell M, et al. Genotype-Dependent and -Independent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy. Circulation. 2016;134:1738-1748 pubmed
产品信息
目录代码 :
A010-12
产品名称 :
Phospholamban Phospho Serine-16
宿主物种 :
兔
克隆性 :
多克隆
抗原修饰 :
磷酸化丝氨酸
产品类型 :
多克隆抗体
规格 :
20微升
基因编号 :
5350
产品等级 :
2
产品描述 :
 Rabbit polyclonal antibody to phospholamban phospho Serine-16.
物种摘要 :
All mammalian species, when phosphorylated on Ser-16.
背景 :
Phospholamban (PLB/PLN) is a small transmembrane protein which plays an important role in controlling the activity of the sarcoplasmic reticulum ATPase (SERCA2a) of cardiac muscle during calcium sequestration. Phospholamban is phosphorylated on separate amino acid residues by cAMP-dependent, and cGMP-dependent (Ser-16) and Ca2+/CaM-dependent (Thr-17) protein kinases in response to beta-adrenergic stimulation. Akt has also been shown to phosphorylate Thr-17. The result is an increased calcium pump activity which reduces the time course of the calcium transient, increases the calcium load in the sarcoplasmic reticulum, and consequently, produces a larger calcium transient at the next action potential. However, alteration in this homeostatic interaction has been shown to result in heart failure
免疫原 :
Phosphopeptide comprising residues 9-19-Y (residues R9SAIRRAS(PO3H2)TIE19Y) conjugated to KLH
特异性 :
All mammalian species, when phosphorylated on Ser-16.
纯度 :
Raw Serum
防腐剂 :
Lyophilised: Contains no preservatives.
包装 :
0.5 ml Cryovial
用途 :
免疫印迹, 酶联免疫吸附测定, 免疫组化
应用摘要 :
WB:(1:5000)
储存 :
Lyophilised antibody is stable at 4 °C when stored with desiccant. Reconstitute lyophilised powder in 20 ul of 18 MΩ H2O, aliquot and store frozen at -80 °C for 1 year. Avoid freese - thaw cycles
产品引用 :
Drago, G. A., and Colyer, J. (1994) J Biol Chem 269, 25073-25077
更多信息或购买 :
Badrilla 产品网页
公司信息
Badrilla
Leeds Innovation Centre
103 Clarendon Road
Leeds, LS2 9DF
info@badrilla.com
http://www.badrilla.com
44-7801-730618
公司总部: 英国
Badrilla Ltd.2003年成立于英国利兹，生产销售优秀的抗体产品、心血管蛋白及磷酸蛋白等。我们从学术带头人处搜寻优秀抗体，并严格验证。与杰出的研究者合作，我们开发能真正提升定量免疫印迹、生物标志物检测及诊断等性能的标准化免疫分析产品。我们的目标是提供加速研究进度并满足期待的高质量产品。