产品简要
公司名称 :
Badrilla
产品类型 :
抗体
产品名称 :
Phospholamban Phospho Threonine-17 Anti-Serum
目录 :
A010-13
规格 :
20微升
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
反应物种 :
人类, 小鼠, 大鼠, domestic rabbit
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
Badrilla 产品网页
文章摘录数: 8
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 3d
Neumann J, Grobe J, Weisgut J, Schwelberger H, Fogel W, Marusakova M, et al. Histamine can be Formed and Degraded in the Human and Mouse Heart. Front Pharmacol. 2021;12:582916 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 5a
Dai W, Laforest B, Tyan L, Shen K, Nadadur R, Alvarado F, et al. A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice. elife. 2019;8: pubmed 出版商
  • 免疫印迹; domestic rabbit; 1:5000; 图 5
Chang S, Chuang H, Chen Y, Kao Y, Lin Y, Yeh Y, et al. Heart failure modulates electropharmacological characteristics of sinoatrial nodes. Exp Ther Med. 2017;13:771-779 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6c
Kennedy T, Swiderski K, Murphy K, Gehrig S, Curl C, Chandramouli C, et al. BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle. Am J Pathol. 2016;186:3246-3260 pubmed 出版商
  • 免疫印迹; 大鼠; 1:5000; 图 s1
Sadredini M, Danielsen T, Aronsen J, Manotheepan R, Hougen K, Sjaastad I, et al. Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure. PLoS ONE. 2016;11:e0153887 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, et al. Heterozygous deletion of sarcolipin maintains normal cardiac function. Am J Physiol Heart Circ Physiol. 2016;310:H92-103 pubmed 出版商
Zhong P, Quan D, Huang Y, Huang H. CaMKII Activation Promotes Cardiac Electrical Remodeling and Increases the Susceptibility to Arrhythmia Induction in High-fat Diet-Fed Mice With Hyperlipidemia Conditions. J Cardiovasc Pharmacol. 2017;70:245-254 pubmed 出版商
Helms A, Alvarado F, Yob J, Tang V, Pagani F, Russell M, et al. Genotype-Dependent and -Independent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy. Circulation. 2016;134:1738-1748 pubmed
产品信息
目录代码 :
A010-13
产品名称 :
Phospholamban Phospho Threonine-17 Anti-Serum
宿主物种 :
兔
克隆性 :
多克隆
抗原修饰 :
磷酸化苏氨酸
产品类型 :
多克隆抗体
规格 :
20微升
基因编号 :
5350
产品等级 :
3
产品描述 :
Rabbit Polyclonal Anti-Serum specific to Thr-17 phosphorylated forms of Phospholamban.
物种摘要 :
All mammalian species, when phosphorylated on Thr-17
背景 :
Phospholamban (PLB/PLN) is a small transmembrane protein which plays an important role in controlling the activity of the sarcoplasmic reticulum ATPase (SERCA2a) of cardiac muscle during calcium sequestration. Phospholamban is phosphorylated on separate amino acid residues by cAMP-dependent, and cGMP-dependent (Ser-16) and Ca2+/CaM-dependent (Thr-17) protein kinases in response to beta-adrenergic stimulation. Akt has also been shown to phosphorylate Thr-17. The result is an increased calcium pump activity which reduces the time course of the calcium transient, increases the calcium load in the sarcoplasmic reticulum, and consequently, produces a larger calcium transient at the next action potential. However, alteration in this homeostatic interaction has been shown to result in heart failure.
免疫原 :
Phosphopeptide comprising residues 9-19-Y (residues R9SAIRRAST(PO3H2)IEY20) conjugated to KLH.
特异性 :
The antibody recognises mono and oligomeric phospholamban when phosphorylated on threonine-17. Binding of the antibody to its target epitope is blocked in the epitope. presence of a phosphopeptide containing the PLB Phospho Thr-17
纯度 :
Raw Serum
防腐剂 :
Lyophilised
包装 :
0.5 ml Cryovial
用途 :
免疫印迹, 酶联免疫吸附测定, 免疫组化
应用摘要 :
WB:(1:5000), IHC:(1:200)
储存 :
Lyophilised antibody is stable at 4 °C when stored with desiccant. Reconstitute lyophilised powder in 20 ul of 18 MΩ H2O, aliquot and store frozen at -80 °C for 1 year. Avoid freese - thaw cycles
产品引用 :
Drago, G. A., and Colyer, J. (1994) J Biol Chem 269, 25073-25077
更多信息或购买 :
Badrilla 产品网页
公司信息
Badrilla
Leeds Innovation Centre
103 Clarendon Road
Leeds, LS2 9DF
info@badrilla.com
http://www.badrilla.com
44-7801-730618
公司总部: 英国
Badrilla Ltd.2003年成立于英国利兹，生产销售优秀的抗体产品、心血管蛋白及磷酸蛋白等。我们从学术带头人处搜寻优秀抗体，并严格验证。与杰出的研究者合作，我们开发能真正提升定量免疫印迹、生物标志物检测及诊断等性能的标准化免疫分析产品。我们的目标是提供加速研究进度并满足期待的高质量产品。