产品简要
公司名称 :
Badrilla
产品类型 :
抗体
产品名称 :
斯里兰卡肉桂咸受体2磷酸化丝氨酸2808抗血清
目录 :
A010-30
规格 :
50微升
价格 :
GBP356.42
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
抗原修饰 :
磷酸化
反应物种 :
人类, 小鼠, 大鼠, 狗, 猪
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化
更多信息或购买 :
Badrilla 产品网页
文章摘录数: 9
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 大鼠; 1:5000; 图 s1
Sadredini M, Danielsen T, Aronsen J, Manotheepan R, Hougen K, Sjaastad I, et al. Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure. PLoS ONE. 2016;11:e0153887 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7f
Mederle K, Gess B, Pluteanu F, Plackic J, Tiefenbach K, Grill A, et al. The angiotensin receptor-associated protein Atrap is a stimulator of the cardiac Ca2+-ATPase SERCA2a. Cardiovasc Res. 2016;110:359-70 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Asensio López M, Soler F, Sánchez Más J, Pascual Figal D, Fernández Belda F, Lax A. Early oxidative damage induced by doxorubicin: Source of production, protection by GKT137831 and effect on Ca(2+) transporters in HL-1 cardiomyocytes. Arch Biochem Biophys. 2016;594:26-36 pubmed 出版商
  • 免疫印迹; 人类; 1:5000; 图 4
Rapti K, Stillitano F, Karakikes I, Nonnenmacher M, Weber T, Hulot J, et al. Effectiveness of gene delivery systems for pluripotent and differentiated cells. Mol Ther Methods Clin Dev. 2015;2:14067 pubmed 出版商
  • 免疫印迹; 猪
Lugenbiel P, Wenz F, Govorov K, Schweizer P, Katus H, Thomas D. Atrial fibrillation complicated by heart failure induces distinct remodeling of calcium cycling proteins. PLoS ONE. 2015;10:e0116395 pubmed 出版商
  • 免疫印迹; 小鼠
Yi T, Vick J, Vecchio M, Begin K, Bell S, Delay R, et al. Identifying cellular mechanisms of zinc-induced relaxation in isolated cardiomyocytes. Am J Physiol Heart Circ Physiol. 2013;305:H706-15 pubmed 出版商
Brandenburg S, Pawlowitz J, Fakuade F, Kownatzki Danger D, Kohl T, Mitronova G, et al. Axial Tubule Junctions Activate Atrial Ca2+ Release Across Species. Front Physiol. 2018;9:1227 pubmed 出版商
Wilder C, Pavlaki N, Dursun T, Gyimah P, Caldwell Dunn E, Ranieri A, et al. Facilitation of ischaemia-induced ventricular fibrillation by catecholamines is mediated by β1 and β2 agonism in the rat heart in vitro. Br J Pharmacol. 2018;175:1669-1690 pubmed 出版商
Besser J, Malan D, Wystub K, Bachmann A, Wietelmann A, Sasse P, et al. MiRNA-1/133a clusters regulate adrenergic control of cardiac repolarization. PLoS ONE. 2014;9:e113449 pubmed 出版商
产品信息
目录代码 :
A010-30
产品名称 :
斯里兰卡肉桂咸受体2磷酸化丝氨酸2808抗血清
宿主物种 :
兔
克隆性 :
多克隆
抗原修饰 :
磷酸化丝氨酸
产品类型 :
多克隆抗体
规格 :
50微升
标价 :
GBP356.42
基因编号 :
6262
产品描述 :
Rabbit Polyclonal anti-serum specific to RYR2 phospho-Ser2808
交叉活性 :
The antibody recognises phosphorylated Serine-2808 of the ryanodine peptide containing the Phospho Ser-2808 epitope.receptor and binding is blocked in the presence of a
物种摘要 :
人类, 大鼠, 小鼠, 兔, 狗, 狗和羊
背景 :
The ryanodine receptor (RyR2) is a Ca2+ channel of cardiac muscle that plays a central role in EC coupling. The binding of Ca2+  to RyR2 opens the channel and Ca2+ stored in the SR moves through the channel into the cytosol to initiate muscle contraction. Abnormal structure and function of ryanodine receptors has been reported in failing hearts, with Ser-2808 phosphorylation appearing elevated in clinical situations which may contribute to the abnormal Ca2+ handling characteristics of cardiac muscle in these conditions. Ser-2808 can be phosphorylated in vitro by PKA or CaMKII, which is coincident with significant change in RyR2 channel function typified by an increased open probability, the abrogation of the inhibitory effects of CaM, and Mg2+, dissociation of regulatory factors, expression of subconductance states and the expression of channel activity at diastolic Ca2+ concentrations. Serine-2808 in human RyR2 equates to Ser-2809 in rabbit RyR2.
免疫原 :
Synthetic peptide (YNRTRRIS(PO3H2)QT2810) conjugated to keyhole limpet haemocyanin
特异性 :
The antibody recognises phosphorylated Serine-2808 of the ryanodine peptide containing the Phospho Ser-2808 epitope.receptor and binding is blocked in the presence of a
纯度 :
Raw Serum
防腐剂 :
Lyophilised:
包装 :
0.5 ml Cryovial
用途 :
免疫印迹, 酶联免疫吸附测定, 免疫组化
应用摘要 :
免疫印迹(1:5000), 免疫组化(1:100), 酶联免疫吸附测定
储存 :
Lyophilised antibody is stable at 4 °C when stored with desiccant. Reconstitute lyophilised powder in 50 ul of 18 MΩ H2O, aliquot and store frozen at -80 °C for 1 year. Avoid freese - thaw cycles
产品引用 :
Carter, S., Colyer, J., & Sitsapesan, R. (2006) Circ. Res. 98, 1506-13
更多信息或购买 :
Badrilla 产品网页
公司信息
Badrilla
Leeds Innovation Centre
103 Clarendon Road
Leeds, LS2 9DF
info@badrilla.com
http://www.badrilla.com
44-7801-730618
公司总部: 英国
Badrilla Ltd.2003年成立于英国利兹，生产销售优秀的抗体产品、心血管蛋白及磷酸蛋白等。我们从学术带头人处搜寻优秀抗体，并严格验证。与杰出的研究者合作，我们开发能真正提升定量免疫印迹、生物标志物检测及诊断等性能的标准化免疫分析产品。我们的目标是提供加速研究进度并满足期待的高质量产品。