产品简要
公司名称 :
Badrilla
产品类型 :
抗体
产品名称 :
 RYR2 Phospho Ser-2814 Anti-Serum
目录 :
A010-31
规格 :
50微升
价格 :
GBP356.42
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
抗原修饰 :
磷酸化
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化-冰冻切片
更多信息或购买 :
Badrilla 产品网页
文章摘录数: 5
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 大鼠; 1:5000; 图 s1
Sadredini M, Danielsen T, Aronsen J, Manotheepan R, Hougen K, Sjaastad I, et al. Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure. PLoS ONE. 2016;11:e0153887 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Asensio López M, Soler F, Sánchez Más J, Pascual Figal D, Fernández Belda F, Lax A. Early oxidative damage induced by doxorubicin: Source of production, protection by GKT137831 and effect on Ca(2+) transporters in HL-1 cardiomyocytes. Arch Biochem Biophys. 2016;594:26-36 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:100
Kim E, Shekhar A, Lu J, Lin X, Liu F, Zhang J, et al. PCP4 regulates Purkinje cell excitability and cardiac rhythmicity. J Clin Invest. 2014;124:5027-36 pubmed 出版商
Zhong P, Quan D, Huang Y, Huang H. CaMKII Activation Promotes Cardiac Electrical Remodeling and Increases the Susceptibility to Arrhythmia Induction in High-fat Diet-Fed Mice With Hyperlipidemia Conditions. J Cardiovasc Pharmacol. 2017;70:245-254 pubmed 出版商
Besser J, Malan D, Wystub K, Bachmann A, Wietelmann A, Sasse P, et al. MiRNA-1/133a clusters regulate adrenergic control of cardiac repolarization. PLoS ONE. 2014;9:e113449 pubmed 出版商
产品信息
目录代码 :
A010-31
产品名称 :
 RYR2 Phospho Ser-2814 Anti-Serum
宿主物种 :
兔
克隆性 :
多克隆
抗原修饰 :
磷酸化丝氨酸
产品类型 :
多克隆抗体
规格 :
50微升
标价 :
GBP356.42
基因编号 :
6262
产品描述 :
Rabbit Polyclonal anti-Serum specific to Ser-2814 phosphorylated RYR2.
交叉活性 :
Recognises Ser-2814 phosphorylated RyR2 exclusively, and will not react with dephosphorylated RyR2 or RyR2 phosphorylated at other sites.
物种摘要 :
Peptide aligns with RyR2 from all mammalian species. Sequence antibody recognises both sequences.corresponds exactly in rabbit but differs at one residue (V2815I) in mouse and rat. However
背景 :
The ryanodine receptor (RyR2) is a Ca2+ channel of cardiac muscle that plays a central role in EC coupling. The binding of Ca2+ to RyR2 opens the channel and Ca2+ stored in the SR moves through the channel into the cytosol to initiate muscle contraction. CaMKII, was able to phosphorylate Ser-2814 of RYR2 enhancing Ca2+- sensitivity and increasing open probability. Excessive phosphorylation of Ser-2814 leads to atrial fibrillation, arrhythmias and sudden death.
免疫原 :
Synthetic peptide (TSQVS(PO3H2)VDAAH2819) corresponding to amino acids surrounding the phosphorylated serine residue at position 2814 of RyR2 (human) conjugated to KLH
特异性 :
Recognises Ser-2814 phosphorylated RyR2 exclusively, and will not react with dephosphorylated RyR2 or RyR2 phosphorylated at other sites.
纯度 :
Raw Serum
防腐剂 :
Lyophilised:
包装 :
0.5 ml Cryovial
用途 :
免疫印迹, 免疫组化
应用摘要 :
 Western blot (1:5000 dilution), IHC Microscopy (1:100 dilution)
储存 :
Lyophilised antibody is stable at 4 °C when stored with desiccant. Reconstitute lyophilised powder in 50 ul of 18 MΩ H2O, aliquot and store frozen at -80 °C for 1 year. Avoid freese - thaw cycles
产品引用 :
Bers, D. M. (2002) Nature 415, 198-205
更多信息或购买 :
Badrilla 产品网页
公司信息
Badrilla
Leeds Innovation Centre
103 Clarendon Road
Leeds, LS2 9DF
info@badrilla.com
http://www.badrilla.com
44-7801-730618
公司总部: 英国
Badrilla Ltd.2003年成立于英国利兹，生产销售优秀的抗体产品、心血管蛋白及磷酸蛋白等。我们从学术带头人处搜寻优秀抗体，并严格验证。与杰出的研究者合作，我们开发能真正提升定量免疫印迹、生物标志物检测及诊断等性能的标准化免疫分析产品。我们的目标是提供加速研究进度并满足期待的高质量产品。