| 出版应用/物种/样本/稀释 | 参考文献 |
|---|
| Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, et al. Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice. J Clin Invest. 2017;127:2235-2248 pubmed 出版商 |
| Bizzarro V, Belvedere R, Migliaro V, Romano E, Parente L, Petrella A. Hypoxia regulates ANXA1 expression to support prostate cancer cell invasion and aggressiveness. Cell Adh Migr. 2017;11:247-260 pubmed 出版商 |
- proximity ligation assay; 小鼠; 1:1000; 图 2a
| Chen W, Hill H, Christie A, Kim M, Holloman E, Pavía Jiménez A, et al. Targeting renal cell carcinoma with a HIF-2 antagonist. Nature. 2016;539:112-117 pubmed 出版商 |
| Jain I, Zazzeron L, Goli R, Alexa K, Schatzman Bone S, Dhillon H, et al. Hypoxia as a therapy for mitochondrial disease. Science. 2016;352:54-61 pubmed 出版商 |
- 免疫印迹; 小鼠; 1:1000; 图 2
- 染色质免疫沉淀
; 人类; 图 2
- 免疫印迹; 人类; 1:1000; 图 2
| Ding M, Bruick R, Yu Y. Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling. Nat Cell Biol. 2016;18:319-27 pubmed 出版商 |
| Murata Y, Uehara Y, Hosoi Y. Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6. Biochem Biophys Res Commun. 2015;468:684-90 pubmed 出版商 |
| Finger E, Cheng C, Williams T, Rankin E, Bedogni B, Tachiki L, et al. CTGF is a therapeutic target for metastatic melanoma. Oncogene. 2014;33:1093-100 pubmed 出版商 |
| Isaacs J, Antony L, Dalrymple S, Brennen W, Gerber S, Hammers H, et al. Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment. Cancer Res. 2013;73:1386-99 pubmed 出版商 |
| Romano E, Vllahu M, Bizzarro V, Belvedere R, Esposito R, Petrella A, et al. TFF1 Promotes EMT-Like Changes through an Auto-Induction Mechanism. Int J Mol Sci. 2018;19: pubmed 出版商 |
| Donzelli S, Milano E, Pruszko M, Sacconi A, Masciarelli S, Iosue I, et al. Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages. Breast Cancer Res. 2018;20:59 pubmed 出版商 |
| Bao L, Chen Y, Lai H, Wu S, Wang J, Hatanpaa K, et al. Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration. Nucleic Acids Res. 2018;46:6576-6591 pubmed 出版商 |
| Gagner J, Sarfraz Y, Ortenzi V, Alotaibi F, Chiriboga L, Tayyib A, et al. Multifaceted C-X-C Chemokine Receptor 4 (CXCR4) Inhibition Interferes with Anti-Vascular Endothelial Growth Factor Therapy-Induced Glioma Dissemination. Am J Pathol. 2017;187:2080-2094 pubmed 出版商 |
| Bruno T, Valerio M, Casadei L, De Nicola F, Goeman F, Pallocca M, et al. Che-1 sustains hypoxic response of colorectal cancer cells by affecting Hif-1α stabilization. J Exp Clin Cancer Res. 2017;36:32 pubmed 出版商 |
| Sorrentino C, Miele L, Porta A, Pinto A, Morello S. Activation of the A2B adenosine receptor in B16 melanomas induces CXCL12 expression in FAP-positive tumor stromal cells, enhancing tumor progression. Oncotarget. 2016;7:64274-64288 pubmed 出版商 |
| Wei K, Piecewicz S, McGinnis L, Taniguchi C, Wiegand S, Anderson K, et al. A liver Hif-2?-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nat Med. 2013;19:1331-1337 pubmed 出版商 |
| Aslam M, Schluter K, Rohrbach S, Rafiq A, Nazli S, Piper H, et al. Hypoxia-reoxygenation-induced endothelial barrier failure: role of RhoA, Rac1 and myosin light chain kinase. J Physiol. 2013;591:461-73 pubmed 出版商 |
| El Filali M, Ly L, Luyten G, Versluis M, Grossniklaus H, van der Velden P, et al. Bevacizumab and intraocular tumors: an intriguing paradox. Mol Vis. 2012;18:2454-67 pubmed |
| Hamidi T, Cano C, Grasso D, Garcia M, Sandi M, Calvo E, et al. Nupr1-aurora kinase A pathway provides protection against metabolic stress-mediated autophagic-associated cell death. Clin Cancer Res. 2012;18:5234-46 pubmed 出版商 |
| Ji K, Tsirka S. Inflammation modulates expression of laminin in the central nervous system following ischemic injury. J Neuroinflammation. 2012;9:159 pubmed 出版商 |
| Zhang L, Das P, Schmolke M, Manicassamy B, Wang Y, Deng X, et al. Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export. J Cell Biol. 2012;196:315-26 pubmed 出版商 |
| Hong S, Jin D, Buck D, Galiano R, Mustoe T. Impaired response of mature adipocytes of diabetic mice to hypoxia. Exp Cell Res. 2011;317:2299-307 pubmed 出版商 |
| Holmberg J, He X, Peredo I, Orrego A, Hesselager G, Ericsson C, et al. Activation of neural and pluripotent stem cell signatures correlates with increased malignancy in human glioma. PLoS ONE. 2011;6:e18454 pubmed 出版商 |
| Wolff N, Vega Rubin de Celis S, Xie X, Castrillon D, Kabbani W, Brugarolas J. Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia. Mol Cell Biol. 2011;31:1870-84 pubmed 出版商 |
| Xu D, Yao Y, Lu L, Costa M, Dai W. Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha. J Biol Chem. 2010;285:38944-50 pubmed 出版商 |
| Welford S, Dorie M, Li X, Haase V, Giaccia A. Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stress. Mol Cell Biol. 2010;30:4595-603 pubmed 出版商 |
| Mendez O, Zavadil J, Esencay M, Lukyanov Y, Santovasi D, Wang S, et al. Knock down of HIF-1alpha in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres. Mol Cancer. 2010;9:133 pubmed 出版商 |
| Lu Z, Shvartsman M, Lee A, Shao J, Murray M, Kladney R, et al. Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis. Cancer Res. 2010;70:3287-98 pubmed 出版商 |
| Costa B, Dettori D, Lorenzato A, Bardella C, Coltella N, Martino C, et al. Fumarase tumor suppressor gene and MET oncogene cooperate in upholding transformation and tumorigenesis. FASEB J. 2010;24:2680-8 pubmed 出版商 |
| El Filali M, Missotten G, Maat W, Ly L, Luyten G, van der Velden P, et al. Regulation of VEGF-A in uveal melanoma. Invest Ophthalmol Vis Sci. 2010;51:2329-37 pubmed 出版商 |
| Porcelli A, Ghelli A, Ceccarelli C, Lang M, Cenacchi G, Capristo M, et al. The genetic and metabolic signature of oncocytic transformation implicates HIF1alpha destabilization. Hum Mol Genet. 2010;19:1019-32 pubmed 出版商 |
| Loinard C, Ginouves A, Vilar J, Cochain C, Zouggari Y, Recalde A, et al. Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization. Circulation. 2009;120:50-9 pubmed 出版商 |
| Vasseur S, Afzal S, Tardivel Lacombe J, Park D, Iovanna J, Mak T. DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses. Proc Natl Acad Sci U S A. 2009;106:1111-6 pubmed 出版商 |
