产品简要
公司名称 :
伯乐（Bio-Rad）公司
其他品牌 :
Biogenesis, Serotec, AbD Serotec, Oxford Biotechnology
产品类型 :
抗体
产品名称 :
大鼠抗MOUSE CD45
目录 :
MCA1388
规格 :
0.25毫克
价格 :
372美元
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
IBL-3/16
反应物种 :
小鼠
应用 :
免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫组化-自由浮动切片
更多信息或购买 :
伯乐（Bio-Rad）公司 产品网页
文章摘录数: 27
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 小鼠; 1:100; 图 3a
Une H, Yamasaki R, Nagata S, Yamaguchi H, Nakamuta Y, Indiasari U, et al. Brain gray matter astroglia-specific connexin 43 ablation attenuates spinal cord inflammatory demyelination. J Neuroinflammation. 2021;18:126 pubmed 出版商
  • 免疫组化; 小鼠; 1:100; 图 5s1e
Ma W, Silverman S, Zhao L, Villasmil R, Campos M, Amaral J, et al. Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization. elife. 2019;8: pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 1a
Gardner P, Liyanage S, Cristante E, Sampson R, Dick A, Ali R, et al. Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye. Sci Rep. 2017;7:40830 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 1:250; 图 s1
Szalay G, Martinecz B, Lénárt N, Kornyei Z, Orsolits B, Judák L, et al. Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke. Nat Commun. 2016;7:11499 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 3a
Tzekov R, Dawson C, Orlando M, Mouzon B, Reed J, Evans J, et al. Sub-Chronic Neuropathological and Biochemical Changes in Mouse Visual System after Repetitive Mild Traumatic Brain Injury. PLoS ONE. 2016;11:e0153608 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:250
Crawford G, Boldison J, Copland D, Adamson P, Gale D, Brandt M, et al. The role of lipoprotein-associated phospholipase A2 in a murine model of experimental autoimmune uveoretinitis. PLoS ONE. 2015;10:e0122093 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 1:250
Lee S, Xu G, Jay T, Bhatta S, Kim K, Jung S, et al. Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway. J Neurosci. 2014;34:12538-46 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 2
Lambertsen K, Østergaard K, Clausen B, Hansen S, Stenvang J, Thorsen S, et al. No effect of ablation of surfactant protein-D on acute cerebral infarction in mice. J Neuroinflammation. 2014;11:123 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠
Hultman K, Cortes Canteli M, Bounoutas A, Richards A, Strickland S, Norris E. Plasmin deficiency leads to fibrin accumulation and a compromised inflammatory response in the mouse brain. J Thromb Haemost. 2014;12:701-12 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 1:250
Bhaskar K, Maphis N, Xu G, Varvel N, Kokiko Cochran O, Weick J, et al. Microglial derived tumor necrosis factor-? drives Alzheimer's disease-related neuronal cell cycle events. Neurobiol Dis. 2014;62:273-85 pubmed 出版商
Markova L, Umek N, Horvat S, Hadzic A, Kuroda M, Pintaric T, et al. Neurotoxicity of bupivacaine and liposome bupivacaine after sciatic nerve block in healthy and streptozotocin-induced diabetic mice. BMC Vet Res. 2020;16:247 pubmed 出版商
Boza Serrano A, Ruiz R, Sanchez Varo R, García Revilla J, Yang Y, Jimenez Ferrer I, et al. Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease. Acta Neuropathol. 2019;: pubmed 出版商
Sawicki C, Kim J, Weber M, Faw T, McKim D, Madalena K, et al. Microglia Promote Increased Pain Behavior through Enhanced Inflammation in the Spinal Cord during Repeated Social Defeat Stress. J Neurosci. 2019;39:1139-1149 pubmed 出版商
Bemiller S, Maphis N, Formica S, Wilson G, Miller C, Xu G, et al. Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy. J Neuroinflammation. 2018;15:278 pubmed 出版商
Liao F, Li A, Xiong M, Bien Ly N, Jiang H, Zhang Y, et al. Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation. J Clin Invest. 2018;128:2144-2155 pubmed 出版商
He P, Cheng X, Staufenbiel M, Li R, Shen Y. Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of ?-secretase in a mouse model of Alzheimer's disease. PLoS ONE. 2013;8:e55091 pubmed 出版商
Kou J, Song M, Pattanayak A, Lim J, Yang J, Cao D, et al. Combined treatment of A? immunization with statin in a mouse model of Alzheimer's disease. J Neuroimmunol. 2012;244:70-83 pubmed 出版商
Gruenenfelder F, Thomson G, Penderis J, Edgar J. Axon-glial interaction in the CNS: what we have learned from mouse models of Pelizaeus-Merzbacher disease. J Anat. 2011;219:33-43 pubmed 出版商
Lodygensky G, West T, Moravec M, Back S, Dikranian K, Holtzman D, et al. Diffusion characteristics associated with neuronal injury and glial activation following hypoxia-ischemia in the immature brain. Magn Reson Med. 2011;66:839-45 pubmed 出版商
Jørgensen L, Blain A, Greally E, Laval S, Blamire A, Davison B, et al. Long-term blocking of calcium channels in mdx mice results in differential effects on heart and skeletal muscle. Am J Pathol. 2011;178:273-83 pubmed 出版商
Santos A, Martín Oliva D, Ferrer Martín R, Tassi M, Calvente R, Sierra A, et al. Microglial response to light-induced photoreceptor degeneration in the mouse retina. J Comp Neurol. 2010;518:477-92 pubmed 出版商
Clausen B, Lambertsen K, Babcock A, Holm T, Dagnaes Hansen F, Finsen B. Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice. J Neuroinflammation. 2008;5:46 pubmed 出版商
Li L, Liu J, Suo W. GRK5 deficiency exaggerates inflammatory changes in TgAPPsw mice. J Neuroinflammation. 2008;5:24 pubmed 出版商
Sato E, Shick H, Ransohoff R, Hirose K. Repopulation of cochlear macrophages in murine hematopoietic progenitor cell chimeras: the role of CX3CR1. J Comp Neurol. 2008;506:930-42 pubmed
Santos A, Calvente R, Tassi M, Carrasco M, Martín Oliva D, Marín Teva J, et al. Embryonic and postnatal development of microglial cells in the mouse retina. J Comp Neurol. 2008;506:224-39 pubmed
He P, Zhong Z, Lindholm K, Berning L, Lee W, Lemere C, et al. Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice. J Cell Biol. 2007;178:829-41 pubmed
Yang Y, Varvel N, Lamb B, Herrup K. Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models. J Neurosci. 2006;26:775-84 pubmed
图像
图像 1 :
伯乐（Bio-Rad）公司 MCA1388 图像 1
Published customer image: . Rat anti Mouse CD45 antibody, clone IBL-3/16 used for the detection of mouse leukocytes by flow cytometry. Image caption: . Infiltration of GFP+ BM-cells in infarct and peri-infarct regions. (A-B) Dot plots of viable macrophages/granulocytes (CD11b+CD45high, top right quadrants) and microglia (CD11b+CD45dim, bottom right quadrants) in cortex from BM-chimeric unmanipulated mice and mice exposed to pMCAO. (C) Bar graph showing mean numbers of CD11b+CD45dim microglia and CD11b+CD45high macrophages/granulocytes in BM-chimeric mice 24 hours after pMCAO, subdivided based on expression of GFP (n = 5). Approximately 92% of of the CD45high population were GFP+ . (D) Estimation and comparison of mean numbers of CD11b+CD45dim microglia in non-chimeric (n = 10) versus BM-chimeric mice (n = 5) 24 hours after of pMCAO shows significantly fewer CD11b+CD45dim microglial cells in irradiated mice. (E) Overview, showing distribution of infiltrating GFP+ BM-derived cells into infarct (IF) and peri-infarct (P-IF) regions 24 hours after pMCAO. (E-G) By 24 hours, GFP+ single cells (F) and vessel-associated aggregates of GFP+ cells (arrows in G) were observed in infarct and peri-infarct regions. Some of the vessel-associated cells were round, leukocyte-like cells (arrows) while others were elongated cells lining the vasculature (arrow heads in G and in insert). (H) Bar graph showing mean numbers of single GFP+ cells and vessel-associated aggregates of GFP+ cells in ipsi- and contralateral cortex 24 hours after surgery (n = 10). (I-P) Immunohistochemical staining of CD45.1 (I, K), CD45.2 (J, L), IgG2a (M, O) and CD45 (N, P) in ischemic tissue in BM-chimeric (I, J, M, N) and non-chimeric mice (K, L, O, P) 24 hours after pMCAO. N.D, none detected. Scale bars: 200 μm (A), 10 μm (B, C). 50 μm (I-P) *P J Neuroinflammation. 2008 Oct 23;5:46.
产品信息
Entity Type :
单克隆抗体
Entity Category :
抗体
ProductCode :
MCA1388
描述 :
大鼠抗MOUSE CD45
特异性 :
CD45
目标物种 :
小鼠
宿主 :
大鼠
格式 :
纯化
Isotypes :
IgG1
应用 :
C*, F, IF, 免疫沉淀
ApplicationTypes :
Immunoprecipitation,Flow Cytometry,Immunohistology - Frozen,Immunofluorescence
克隆 :
IBL-3/16
规格 :
0.25毫克
Quantity Value :
0.25
规格类型 :
毫克
GO登录号 :
GO:0050732, GO:0050852, GO:0050853, GO:0050855, GO:0050857, GO:0051209, GO:0051607, GO:0030890, GO:0030183, GO:0034113, GO:0031953, GO:0042098, GO:0042100, GO:0043065, GO:0043395, GO:0045059, GO:0043410, GO:0045121, GO:0045060, GO:0045588, GO:0045577, GO:0046641, GO:0048304, GO:0005925, GO:0006470, GO:0006469, GO:0007159, GO:0008201, GO:0019901, GO:0009897, GO:0051726, GO:0002925, GO:0005887, GO:0004725, GO:0001960, GO:0001916, GO:0001915, GO:0000187
GOTerms :
activation of MAP kinase,activation of MAPK activity during sporulation,MAPK activation,down regulation of T cell mediated cytotoxicity,downregulation of T cell mediated cytotoxicity,down-regulation of T cell mediated cytotoxicity,inhibition of T cell mediated cytotoxicity,negative regulation of T cell mediated apoptosis,negative regulation of T cell mediated cell death,negative regulation of T cell mediated cell killing,negative regulation of T cell mediated cytolysis,negative regulation of T lymphocyte mediated cytotoxicity,negative regulation of T-cell mediated apoptosis,negative regulation of T-cell mediated cell death,negative regulation of T-cell mediated cell killing,negative regulation of T-cell mediated cytolysis,negative regulation of T-cell mediated cytotoxicity,negative regulation of T-lymphocyte mediated cytotoxicity,activation of T cell mediated cytotoxicity,positive regulation of T cell mediated apoptosis,positive regulation of T cell mediated cell death,positive regulation of T cell mediated cell killing,positive regulation of T cell mediated cytolysis,positive regulation of T lymphocyte mediated cytotoxicity,positive regulation of T-cell mediated apoptosis,positive regulation of T-cell mediated cell death,positive regulation of T-cell mediated cell killing,positive regulation of T-cell mediated cytolysis,positive regulation of T-cell mediated cytotoxicity,positive regulation of T-lymphocyte mediated cytotoxicity,stimulation of T cell mediated cytotoxicity,up regulation of T cell mediated cytotoxicity,upregulation of T cell mediated cytotoxicity,up-regulation of T cell mediated cytotoxicity,down regulation of cytokine mediated signaling pathway,downregulation of cytokine mediated signaling pathway,down-regulation of cytokine mediated signaling pathway,inhibition of cytokine mediated signaling pathway,negative regulation of cytokine and chemokine mediated signaling pathway,negative regulation of cytokine mediated signaling pathway,negative regulation of cytokine mediated signalling pathway,activation of humoral immune response mediated by circulating immunoglobulin,stimulation of humoral immune response mediated by circulating immunoglobulin,up regulation of humoral immune response mediated by circulating immunoglobulin,upregulation of humoral immune response mediated by circulating immunoglobulin,up-regulation of humoral immune response mediated by circulating immunoglobulin,cell cycle control,cell cycle modulation,cell cycle regulation,cell cycle regulator,control of cell cycle progression,GO:0000074,modulation of cell cycle progression,regulation of cell cycle progression,regulation of progression through cell cycle,tumor suppressor,[phosphotyrosine]protein phosphatase activity,phosphoprotein phosphatase (phosphotyrosine) activity,phosphotyrosine histone phosphatase activity,phosphotyrosine phosphatase activity,phosphotyrosine protein phosphatase activity,phosphotyrosylprotein phosphatase activity,PPT-phosphatase activity,protein phosphotyrosine phosphatase activity,protein-tyrosine-phosphatase activity,protein-tyrosine-phosphate phosphohydrolase activity,PTPase activity,PTP-phosphatase activity,tyrosine O-phosphate phosphatase activity,tyrosylprotein phosphatase activity,focal contact,GO:0008357,hemi-adherens junction,down regulation of protein kinase activity,downregulation of protein kinase activity,down-regulation of protein kinase activity,inhibition of protein kinase activity,protein amino acid dephosphorylation,leukocyte adhesion,leukocyte cell adhesion,heparan sulfate binding,juxtamembrane,outer surface of cytoplasmic membrane,B cell development,B lymphocyte differentiation,B-cell differentiation,B-lymphocyte differentiation,GO:0042115,activation of B cell proliferation,positive regulation of B lymphocyte proliferation,positive regulation of B-cell proliferation,positive regulation of B-lymphocyte proliferation,stimulation of B cell proliferation,up regulation of B cell proliferation,upregulation of B cell proliferation,up-regulation of B cell proliferation,down regulation of protein amino acid autophosphorylation,downregulation of protein amino acid autophosphorylation,down-regulation of protein amino acid autophosphorylation,inhibition of protein amino acid autophosphorylation,negative regulation of protein amino acid autophosphorylation,GO:0042111,T lymphocyte proliferation,T-cell proliferation,T-lymphocyte proliferation,B lymphocyte proliferation,B-cell proliferation,B-lymphocyte proliferation,GO:0042114,activation of apoptosis,stimulation of apoptosis,up regulation of apoptosis,upregulation of apoptosis,up-regulation of apoptosis,heparin proteoglycan binding,activation of MAPKKK cascade,positive regulation of MAP kinase kinase kinase cascade,positive regulation of mitogen activated protein kinase kinase kinase cascade,positive regulation of mitogen-activated protein kinase kinase kinase cascade,stimulation of MAPKKK cascade,up regulation of MAPKKK cascade,upregulation of MAPKKK cascade,up-regulation of MAPKKK cascade,positive thymic T lymphocyte selection,positive thymic T-cell selection,positive thymic T-lymphocyte selection,negative thymic T lymphocyte selection,negative thymic T-cell selection,negative thymic T-lymphocyte selection,GEM domain,glycolipid-enriched membrane domain,lipid raft,regulation of B cell development,regulation of B lymphocyte differentiation,regulation of B-cell differentiation,regulation of B-lymphocyte differentiation,activation of gamma-delta T cell differentiation,positive regulation of gamma-delta T cell development,positive regulation of gamma-delta T lymphocyte differentiation,positive regulation of gamma-delta T-cell differentiation,positive regulation of gamma-delta T-lymphocyte differentiation,stimulation of gamma-delta T cell differentiation,up regulation of gamma-delta T cell differentiation,up-regulation of gamma-delta T cell differentiation,upregulation of gamma-delta T cell differentiation,activation of alpha-beta T cell proliferation,positive regulation of alpha-beta T lymphocyte proliferation,positive regulation of alpha-beta T-cell proliferation,positive regulation of alpha-beta T-lymphocyte proliferation,stimulation of alpha-beta T cell proliferation,up regulation of alpha-beta T cell proliferation,up-regulation of alpha-beta T cell proliferation,upregulation of alpha-beta T cell proliferation,activation of isotype switching to IgG isotypes,positive regulation of class switch recombination to IgG isotypes,positive regulation of class switching to IgG isotypes,positive regulation of isotype switch recombination to IgG isotypes,stimulation of isotype switching to IgG isotypes,up regulation of isotype switching to IgG isotypes,upregulation of isotype switching to IgG isotypes,up-regulation of isotype switching to IgG isotypes,down regulation of peptidyl-tyrosine phosphorylation,down-regulation of peptidyl-tyrosine phosphorylation,downregulation of peptidyl-tyrosine phosphorylation,inhibition of peptidyl-tyrosine phosphorylation,T lymphocyte receptor signaling pathway,T lymphocyte receptor signalling pathway,T-cell receptor signaling pathway,T-cell receptor signalling pathway,TCR signaling pathway,T-lymphocyte receptor signaling pathway,T-lymphocyte receptor signalling pathway,B cell receptor signalling pathway,B lymphocyte receptor signaling pathway,B lymphocyte receptor signalling pathway,B-cell receptor signaling pathway,B-cell receptor signalling pathway,B-lymphocyte receptor signaling pathway,B-lymphocyte receptor signalling pathway,regulation of B cell receptor signalling pathway,regulation of B lymphocyte receptor signaling pathway,regulation of B lymphocyte receptor signalling pathway,regulation of B-cell receptor signaling pathway,regulation of B-cell receptor signalling pathway,regulation of B-lymphocyte receptor signaling pathway,regulation of B-lymphocyte receptor signalling pathway,activation of antigen receptor-mediated signaling pathway,positive regulation of antigen receptor mediated signalling pathway,stimulation of antigen receptor-mediated signaling pathway,up regulation of antigen receptor-mediated signaling pathway,up-regulation of antigen receptor-mediated signaling pathway,upregulation of antigen receptor-mediated signaling pathway,calcium ion (Ca2+) mobilization,calcium mobilization,cytoplasmic release of sequestered calcium ion (Ca2+),cytoplasmic release of stored calcium ion (Ca2+),cytosolic release of sequestered calcium ion (Ca2+),cytosolic release of stored calcium ion (Ca2+),release of sequestered calcium ion (Ca2+),release of sequestered calcium ion into cytoplasm,release of stored calcium ion (Ca2+),release of stored calcium ion (Ca2+) into cytoplasm,release of stored calcium ion (Ca2+) into cytosol,antiviral response,defence response to virus,defense response to viruses
UniProt数据库登录号 :
P06800
基因 :
蛋白酪氨酸磷酸酶受体C
GeneID网址 :
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=19264
出版同义词 :
LCA
Entity Formats :
纯化
UNSPSC :
41116161
浓度 :
IgG浓度0.5毫克/毫升
产品形式 :
纯化IgG-液体
PriceGBP :
266
PriceEUR :
372
PriceUSD :
372美元
PriceCHF :
405
PriceSEK :
4055
PriceNOK :
4075
PriceDKK :
2774
更多信息或购买 :
伯乐（Bio-Rad）公司 产品网页
公司信息
伯乐（Bio-Rad）公司
Endeavour House, Langford Business Park
Langford Lane, Kidlington
OXON, OX5 1GE
antibody_sales_uk@bio-rad.com
https://www.bio-rad-antibodies.com
44-1865-852-700
公司总部: 英国
伯乐（Bio-Rad）公司是世界领先的抗体生产商之一。通过其原名为AbD Serotec公司的专业抗体业务团队，提供超过12,000种抗体及相关试剂，专注于免疫学、肿瘤、兽医研究及细胞生物学等领域。
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