产品简要
公司名称 :
Bio X Cell
产品类型 :
抗体
产品名称 :
InVivoMAb抗小鼠CD4
目录 :
BE0003-1毫克
规格 :
5毫克
价格 :
390.00美元
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
GK1.5
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 流式细胞仪, 抑制或激活实验, 其他
更多信息或购买 :
文章摘录数: 49
出版应用/物种/样本/稀释参考文献
  • 抑制或激活实验; 小鼠; ; 图 7b
Fan P, Qiang H, Liu Z, Zhao Q, Wang Y, Liu T, et al. Effective low-dose Anlotinib induces long-term tumor vascular normalization and improves anti-PD-1 therapy. Front Immunol. 2022;13:937924 pubmed 出版商
  • 抑制或激活实验; 小鼠; ; 图 2d
Aiken T, Erbe A, Zebertavage L, Komjathy D, Feils A, Rodriguez M, et al. Mechanism of effective combination radio-immunotherapy against 9464D-GD2, an immunologically cold murine neuroblastoma. J Immunother Cancer. 2022;10: pubmed 出版商
  • 抑制或激活实验; 小鼠; ; 图 3a
Maruyama J, Reyna R, Kishimoto Urata M, Urata S, Manning J, Harsell N, et al. CD4 T-cell depletion prevents Lassa fever associated hearing loss in the mouse model. PLoS Pathog. 2022;18:e1010557 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 2e
Yokomizo K, Waki K, Ozawa M, Yamamoto K, Ogasawara S, Yano H, et al. Knockout of high-mobility group box 1 in B16F10 melanoma cells induced host immunity-mediated suppression of in vivo tumor growth. Med Oncol. 2022;39:58 pubmed 出版商
  • 其他; 小鼠; 图 s6i
  • 免疫组化; 小鼠; 图 1
  • 免疫组化; 人类; 图 1
Pasciuto E, Burton O, Roca C, Lagou V, Rajan W, Theys T, et al. Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition. Cell. 2020;182:625-640.e24 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3e
Zhou T, Damsky W, Weizman O, McGeary M, Hartmann K, Rosen C, et al. IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy. Nature. 2020;583:609-614 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 4g
  • 流式细胞仪; 小鼠; 图 1a
Chen H, Cong X, Wu C, Wu X, Wang J, Mao K, et al. Intratumoral delivery of CCL25 enhances immunotherapy against triple-negative breast cancer by recruiting CCR9+ T cells. Sci Adv. 2020;6:eaax4690 pubmed 出版商
  • 其他; 小鼠
Lee J, Stone M, Porrett P, Thomas S, Komar C, Li J, et al. Hepatocytes direct the formation of a pro-metastatic niche in the liver. Nature. 2019;567:249-252 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 s8
Ruscetti M, Leibold J, Bott M, Fennell M, Kulick A, Salgado N, et al. NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Science. 2018;362:1416-1422 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 2a
Sato Y, Bolzenius J, Eteleeb A, Su X, Maher C, Sehn J, et al. CD4+ T cells induce rejection of urothelial tumors after immune checkpoint blockade. JCI Insight. 2018;3: pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 s3a
Dong S, Harrington B, Hu E, Greene J, Lehman A, Tran M, et al. PI3K p110δ inactivation antagonizes chronic lymphocytic leukemia and reverses T cell immune suppression. J Clin Invest. 2019;129:122-136 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 7a
Kortlever R, Sodir N, Wilson C, Burkhart D, Pellegrinet L, Brown Swigart L, et al. Myc Cooperates with Ras by Programming Inflammation and Immune Suppression. Cell. 2017;171:1301-1315.e14 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 3d
Singh M, Vianden C, Cantwell M, Dai Z, Xiao Z, Sharma M, et al. Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain. Nat Commun. 2017;8:1447 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 10
Earl P, Americo J, Moss B. Insufficient Innate Immunity Contributes to the Susceptibility of the Castaneous Mouse to Orthopoxvirus Infection. J Virol. 2017;91: pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 s6a
Billerbeck E, Wolfisberg R, Fahnøe U, Xiao J, Quirk C, Luna J, et al. Mouse models of acute and chronic hepacivirus infection. Science. 2017;357:204-208 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 6a
Kwan B, Zhu E, Tzeng A, Sugito H, Eltahir A, Ma B, et al. Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses. J Exp Med. 2017;214:1679-1690 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 7h
Daley D, Mani V, Mohan N, Akkad N, Pandian G, Savadkar S, et al. NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma. J Exp Med. 2017;214:1711-1724 pubmed 出版商
  • 抑制或激活实验; 小鼠
  • 流式细胞仪; 小鼠; 图 s2c
Tian L, Goldstein A, Wang H, Ching Lo H, Sun Kim I, Welte T, et al. Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming. Nature. 2017;544:250-254 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 6a
Klein J, Moses K, Zelinskyy G, Sody S, Buer J, Lang S, et al. Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth. Nat Commun. 2017;8:14600 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5b
Yanagita T, Murata Y, Tanaka D, Motegi S, Arai E, Daniwijaya E, et al. Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy. JCI Insight. 2017;2:e89140 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 5a
Rowe A, Yun H, Treat B, Kinchington P, Hendricks R. Subclinical Herpes Simplex Virus Type 1 Infections Provide Site-Specific Resistance to an Unrelated Pathogen. J Immunol. 2017;198:1706-1717 pubmed 出版商
  • 抑制或激活实验; 小鼠
Aguilera T, Rafat M, Castellini L, Shehade H, Kariolis M, Hui A, et al. Reprogramming the immunological microenvironment through radiation and targeting Axl. Nat Commun. 2016;7:13898 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 3a
Swanson P, Hart G, Russo M, Nayak D, Yazew T, Pena M, et al. CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature. PLoS Pathog. 2016;12:e1006022 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 2f
Wang S, Campos J, Gallotta M, Gong M, Crain C, Naik E, et al. Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8+ T cells. Proc Natl Acad Sci U S A. 2016;113:E7240-E7249 pubmed
  • 抑制或激活实验; 小鼠
Pauken K, Sammons M, Odorizzi P, Manne S, Godec J, Khan O, et al. Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade. Science. 2016;354:1160-1165 pubmed
  • 抑制或激活实验; 小鼠; 图 s9b
Hirai Yuki A, Hensley L, McGivern D, Gonzalez Lopez O, Das A, Feng H, et al. MAVS-dependent host species range and pathogenicity of human hepatitis A virus. Science. 2016;353:1541-1545 pubmed
  • 抑制或激活实验; 小鼠; 图 s8
Larocca R, Abbink P, Peron J, Zanotto P, Iampietro M, Badamchi Zadeh A, et al. Vaccine protection against Zika virus from Brazil. Nature. 2016;536:474-8 pubmed
  • 抑制或激活实验; 小鼠; 图 3
Azpilikueta A, Agorreta J, Labiano S, Pérez Gracia J, Sánchez Paulete A, Aznar M, et al. Successful Immunotherapy against a Transplantable Mouse Squamous Lung Carcinoma with Anti-PD-1 and Anti-CD137 Monoclonal Antibodies. J Thorac Oncol. 2016;11:524-36 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 8E
Bouchery T, Kyle R, Camberis M, Shepherd A, Filbey K, Smith A, et al. ILC2s and T cells cooperate to ensure maintenance of M2 macrophages for lung immunity against hookworms. Nat Commun. 2015;6:6970 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s1
Becker A, Walcheck B, Bhattacharya D. ADAM17 limits the expression of CSF1R on murine hematopoietic progenitors. Exp Hematol. 2015;43:44-52.e1-3 pubmed 出版商
Balogh K, Templeton D, Cross J. Macrophage Migration Inhibitory Factor protects cancer cells from immunogenic cell death and impairs anti-tumor immune responses. PLoS ONE. 2018;13:e0197702 pubmed 出版商
Budda S, Zenewicz L. IL-22 deficiency increases CD4 T cell responses to mucosal immunization. Vaccine. 2018;36:3694-3700 pubmed 出版商
Zeppa J, Kasper K, Mohorovic I, Mazzuca D, Haeryfar S, McCormick J. Nasopharyngeal infection by Streptococcus pyogenes requires superantigen-responsive V?-specific T cells. Proc Natl Acad Sci U S A. 2017;: pubmed 出版商
Moynihan K, Opel C, Szeto G, Tzeng A, Zhu E, Engreitz J, et al. Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses. Nat Med. 2016;22:1402-1410 pubmed 出版商
Guo L, Huang Y, Chen X, Hu Li J, Urban J, Paul W. Innate immunological function of TH2 cells in vivo. Nat Immunol. 2015;16:1051-9 pubmed 出版商
Kim J, Jeong Ryu S, Oh K, Ju J, Yeong Jeon J, Nam G, et al. Memory programming in CD8(+) T-cell differentiation is intrinsic and is not determined by CD4 help. Nat Commun. 2015;6:7994 pubmed 出版商
Liu G, Xu J, Wu H, Sun D, Zhang X, Zhu X, et al. IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4+ T Cells and IFN-γ. PLoS Pathog. 2015;11:e1005065 pubmed 出版商
Zander R, Obeng Adjei N, Guthmiller J, Kulu D, Li J, Ongoiba A, et al. PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity. Cell Host Microbe. 2015;17:628-41 pubmed 出版商
Vanpouille Box C, Diamond J, Pilones K, Zavadil J, Babb J, Formenti S, et al. TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity. Cancer Res. 2015;75:2232-42 pubmed 出版商
Evans E, Jonason A, Bussler H, Torno S, Veeraraghavan J, Reilly C, et al. Antibody Blockade of Semaphorin 4D Promotes Immune Infiltration into Tumor and Enhances Response to Other Immunomodulatory Therapies. Cancer Immunol Res. 2015;3:689-701 pubmed 出版商
Christensen A, Skov S, Kvist P, Haase C. Depletion of regulatory T cells in a hapten-induced inflammation model results in prolonged and increased inflammation driven by T cells. Clin Exp Immunol. 2015;179:485-99 pubmed 出版商
Xin L, Jiang T, Chaturvedi V, Kinder J, Ertelt J, Rowe J, et al. Commensal microbes drive intestinal inflammation by IL-17-producing CD4+ T cells through ICOSL and OX40L costimulation in the absence of B7-1 and B7-2. Proc Natl Acad Sci U S A. 2014;111:10672-7 pubmed 出版商
Krupnick A, Lin X, Li W, Higashikubo R, Zinselmeyer B, Hartzler H, et al. Central memory CD8+ T lymphocytes mediate lung allograft acceptance. J Clin Invest. 2014;124:1130-43 pubmed 出版商
Uddin M, Zhang Y, Harton J, MacNamara K, Avram D. TNF-?-dependent hematopoiesis following Bcl11b deletion in T cells restricts metastatic melanoma. J Immunol. 2014;192:1946-53 pubmed 出版商
Church S, Jensen S, Antony P, Restifo N, Fox B. Tumor-specific CD4+ T cells maintain effector and memory tumor-specific CD8+ T cells. Eur J Immunol. 2014;44:69-79 pubmed 出版商
Dai M, Wei H, Yip Y, Feng Q, He K, Popov V, et al. Long-lasting complete regression of established mouse tumors by counteracting Th2 inflammation. J Immunother. 2013;36:248-57 pubmed 出版商
Hervieu A, Rébé C, Vegran F, Chalmin F, Bruchard M, Vabres P, et al. Dacarbazine-mediated upregulation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth. J Invest Dermatol. 2013;133:499-508 pubmed 出版商
Butler N, Moebius J, Pewe L, Traore B, Doumbo O, Tygrett L, et al. Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection. Nat Immunol. 2011;13:188-95 pubmed 出版商
Krieg C, Létourneau S, Pantaleo G, Boyman O. Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells. Proc Natl Acad Sci U S A. 2010;107:11906-11 pubmed 出版商
产品信息
目录号 :
BE0003-1毫克
产品名称 :
InVivoMAb抗小鼠CD4
宿主 :
大鼠
克隆性 :
单克隆
标记/共轭 :
No
抗原修饰 :
No
类别 :
抗体
规格 :
5毫克
Regular Price :
$600.00
Academic Price :
390.00美元
克隆名称 :
GK1.5
抗体亚型 :
GK1.5
免疫原 :
小鼠CTL克隆V4
反应物种 :
小鼠
浓度/数量 :
Lot specific,typically between 4-11 mg/ml
Reported Applications :
in vivo CD4+ T cell depletion, Flow cytometry, Western blot
Recommended Storage Conditions :
The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
更多信息或购买 :
公司信息
Bio X Cell
10 Technology Dr., Suite 2B
Lebanon, NH 03784-1671
customerservice@bxcell.com
http://bxcell.com
1-866-787-3444
公司总部: 美国