产品简要
公司名称 :
BioLegend
其他品牌 :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
产品类型 :
抗体
产品名称 :
亮紫色785™抗小鼠CD4
目录 :
100453
规格 :
50微克
价格 :
273美元
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
亮紫色785
克隆名称 :
GK1.5
反应物种 :
小鼠
应用 :
免疫印迹, 免疫组化, 流式细胞仪, 抑制或激活实验
更多信息或购买 :
文章摘录数: 54
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 1:200; 图 6h
Smith K, Minns D, McHugh B, Holloway R, O CONNOR R, Williams A, et al. The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation. PLoS Biol. 2022;20:e3001554 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:200; 图 1a, 4d
Minns D, Smith K, Alessandrini V, Hardisty G, Melrose L, Jackson Jones L, et al. The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation. Nat Commun. 2021;12:1285 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:100; 图 2g
Sanchez Felipe L, Vercruysse T, Sharma S, Ma J, Lemmens V, Van Looveren D, et al. A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate. Nature. 2021;590:320-325 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 e10
Majer O, Liu B, Kreuk L, Krogan N, Barton G. UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity. Nature. 2019;575:366-370 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:200; 图 s5a, s6a
Ansaldo E, Slayden L, Ching K, Koch M, Wolf N, Plichta D, et al. Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis. Science. 2019;364:1179-1184 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 6e
Obeid S, Wankell M, Charrez B, Sternberg J, Kreuter R, Esmaili S, et al. Adiponectin confers protection from acute colitis and restricts a B cell immune response. J Biol Chem. 2017;292:6569-6582 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 4d
Zan H, Tat C, Qiu Z, Taylor J, Guerrero J, Shen T, et al. Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination. Nat Commun. 2017;8:14244 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2b
Kinosada H, Yasunaga J, Shimura K, Miyazato P, Onishi C, Iyoda T, et al. HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors. PLoS Pathog. 2017;13:e1006120 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3c
Wei Y, Lu C, Chen J, Cui G, Wang L, Yu T, et al. High salt diet stimulates gut Th17 response and exacerbates TNBS-induced colitis in mice. Oncotarget. 2017;8:70-82 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 4b
Kirschbaum K, Sonner J, Zeller M, Deumelandt K, Bode J, Sharma R, et al. In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis. Proc Natl Acad Sci U S A. 2016;113:13227-13232 pubmed
  • 流式细胞仪; 小鼠; 图 2
Huang M, Zhang W, Guo J, Wei X, Phiwpan K, Zhang J, et al. Improved Transgenic Mouse Model for Studying HLA Class I Antigen Presentation. Sci Rep. 2016;6:33612 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 S2
Uhde A, Herder V, Akram Khan M, Ciurkiewicz M, Schaudien D, Teich R, et al. Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice. PLoS ONE. 2016;11:e0161883 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2a
Hoegl S, Ehrentraut H, Brodsky K, Victorino F, Golden Mason L, Eltzschig H, et al. NK cells regulate CXCR2+ neutrophil recruitment during acute lung injury. J Leukoc Biol. 2017;101:471-480 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:200
Lu X, Chen Q, Rong Y, Yang G, Li C, Xu N, et al. LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells. Nat Commun. 2016;7:12719 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5a
Parsa R, Lund H, Georgoudaki A, Zhang X, Ortlieb Guerreiro Cacais A, Grommisch D, et al. BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis. J Exp Med. 2016;213:1537-53 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1f
Ibiza S, García Cassani B, Ribeiro H, Carvalho T, Almeida L, Marques R, et al. Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence. Nature. 2016;535:440-443 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:300; 图 4e
Riedel A, Shorthouse D, Haas L, Hall B, Shields J. Tumor-induced stromal reprogramming drives lymph node transformation. Nat Immunol. 2016;17:1118-27 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2a
Contreras F, Prado C, Gonzalez H, Franz D, Osorio Barrios F, Osorio F, et al. Dopamine Receptor D3 Signaling on CD4+ T Cells Favors Th1- and Th17-Mediated Immunity. J Immunol. 2016;196:4143-9 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5
Li Y, Nishikawa T, Kaneda Y. Platelet-cytokine Complex Suppresses Tumour Growth by Exploiting Intratumoural Thrombin-dependent Platelet Aggregation. Sci Rep. 2016;6:25077 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:200; 图 1a
O Leary C, Riling C, Spruce L, Ding H, Kumar S, Deng G, et al. Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells. Nat Commun. 2016;7:11226 pubmed 出版商
  • 免疫组化; 小鼠; 1:100; 图 1
Chen W, Cao Z, Sugaya S, Lopez M, Sendra V, Laver N, et al. Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3. Nat Commun. 2016;7:11302 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s3
Yang Y, Xu J, Chen H, Fei X, Tang Y, Yan Y, et al. MiR-128-2 inhibits common lymphoid progenitors from developing into progenitor B cells. Oncotarget. 2016;7:17520-31 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 6
Apostolidis S, Rodríguez Rodríguez N, Suárez Fueyo A, Dioufa N, Ozcan E, Crispín J, et al. Phosphatase PP2A is requisite for the function of regulatory T cells. Nat Immunol. 2016;17:556-64 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 7d
McFarland B, Marks M, Rowse A, Fehling S, Gerigk M, Qin H, et al. Loss of SOCS3 in myeloid cells prolongs survival in a syngeneic model of glioma. Oncotarget. 2016;7:20621-35 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2a
Yang Y, Poe J, Yang L, Fedoriw A, Desai S, Magnuson T, et al. Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo. Nucleic Acids Res. 2016;44:4174-88 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1
Haque M, Song J, Fino K, Sandhu P, Song X, Lei F, et al. Stem cell-derived tissue-associated regulatory T cells ameliorate the development of autoimmunity. Sci Rep. 2016;6:20588 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Kuipers H, Rieck M, Gurevich I, Nagy N, Butte M, Negrin R, et al. Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization. Proc Natl Acad Sci U S A. 2016;113:1339-44 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3
Lasigliè D, Boero S, Bauer I, Morando S, Damonte P, Cea M, et al. Sirt6 regulates dendritic cell differentiation, maturation, and function. Aging (Albany NY). 2016;8:34-49 pubmed
  • 流式细胞仪; 小鼠; 图 1
  • 免疫组化; 小鼠; 图 1
Adachi T, Kobayashi T, Sugihara E, Yamada T, Ikuta K, Pittaluga S, et al. Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma. Nat Med. 2015;21:1272-9 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5
Venkatasubramanian S, Tripathi D, Tucker T, Paidipally P, Cheekatla S, Welch E, et al. Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection. Eur J Immunol. 2016;46:464-79 pubmed 出版商
  • 流式细胞仪; 小鼠
Jones D, Wilmore J, Allman D. Cellular Dynamics of Memory B Cell Populations: IgM+ and IgG+ Memory B Cells Persist Indefinitely as Quiescent Cells. J Immunol. 2015;195:4753-9 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s3
Murayama M, Kakuta S, Inoue A, Umeda N, Yonezawa T, Maruhashi T, et al. CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis. Nat Commun. 2015;6:8483 pubmed 出版商
  • 流式细胞仪; 小鼠; 10 ug/ml; 图 7a
Sasaki K, Takada K, Ohte Y, Kondo H, Sorimachi H, Tanaka K, et al. Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells. Nat Commun. 2015;6:7484 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Durrans A, Gao D, Gupta R, Fischer K, Choi H, El Rayes T, et al. Identification of Reprogrammed Myeloid Cell Transcriptomes in NSCLC. PLoS ONE. 2015;10:e0129123 pubmed 出版商
  • 抑制或激活实验; 小鼠
Rao E, Zhang Y, Zhu G, Hao J, Persson X, Egilmez N, et al. Deficiency of AMPK in CD8+ T cells suppresses their anti-tumor function by inducing protein phosphatase-mediated cell death. Oncotarget. 2015;6:7944-58 pubmed
  • 免疫印迹; 小鼠; 1:100; 图 5,6
Hsiao H, Hsu T, Liu W, Hsieh W, Chou T, Wu Y, et al. Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo. Nat Commun. 2015;6:6353 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:200
Kanayama M, Inoue M, Danzaki K, Hammer G, He Y, Shinohara M. Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. Nat Commun. 2015;6:5779 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 8f
Minkah N, Macaluso M, Oldenburg D, Paden C, White D, McBride K, et al. Absence of the uracil DNA glycosylase of murine gammaherpesvirus 68 impairs replication and delays the establishment of latency in vivo. J Virol. 2015;89:3366-79 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1
Nguyen L, Pan J, Dinh T, Hadeiba H, O Hara E, Ebtikar A, et al. Role and species-specific expression of colon T cell homing receptor GPR15 in colitis. Nat Immunol. 2015;16:207-213 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1e
Li Q, Zou J, Wang M, Ding X, Chepelev I, Zhou X, et al. Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation. Nat Commun. 2014;5:5780 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 4
Kawai Y, Ouchida R, Yamasaki S, Dragone L, Tsubata T, Wang J. LAPTM5 promotes lysosomal degradation of intracellular CD3? but not of cell surface CD3?. Immunol Cell Biol. 2014;92:527-34 pubmed 出版商
  • 流式细胞仪; 小鼠
Vanoaica L, Richman L, Jaworski M, Darshan D, Luther S, Kühn L. Conditional deletion of ferritin h in mice reduces B and T lymphocyte populations. PLoS ONE. 2014;9:e89270 pubmed 出版商
  • 流式细胞仪; 小鼠
McGuire D, Rowse A, Li H, Peng B, Sestero C, Cashman K, et al. CD5 enhances Th17-cell differentiation by regulating IFN-? response and ROR?t localization. Eur J Immunol. 2014;44:1137-42 pubmed 出版商
Mastandrea I, Sher D, Magod P, Friedmann Morvinski D. Isolation and characterization of the immune cell fraction from murine brain tumor microenvironment. STAR Protoc. 2022;3:101106 pubmed 出版商
Becker W, Alrafas H, Busbee P, Walla M, Wilson K, Miranda K, et al. Cannabinoid Receptor Activation on Haematopoietic Cells and Enterocytes Protects against Colitis. J Crohns Colitis. 2021;15:1032-1048 pubmed 出版商
Wanner Seleznik G, Reding T, Chen R, Gupta A, Lenggenhager D, Browning J, et al. Amelioration of Murine Autoimmune Pancreatitis by Targeted LTβR Inhibition and Anti-CD20 Treatment. Immunohorizons. 2020;4:688-700 pubmed 出版商
Cassidy B, Zhang M, Sonntag W, Drevets D. Neuroinvasive Listeria monocytogenes infection triggers accumulation of brain CD8+ tissue-resident memory T cells in a miR-155-dependent fashion. J Neuroinflammation. 2020;17:259 pubmed 出版商
Ni J, Wang X, Stojanovic A, Zhang Q, Wincher M, Bühler L, et al. Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity. Immunity. 2020;52:1075-1087.e8 pubmed 出版商
Kurniawan H, Franchina D, Guerra L, Bonetti L, Baguet L, Grusdat M, et al. Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function. Cell Metab. 2020;31:920-936.e7 pubmed 出版商
Moufarrij S, Srivastava A, Gomez S, Hadley M, Palmer E, Austin P, et al. Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer. Sci Rep. 2020;10:3470 pubmed 出版商
Zhang H, Christensen C, Dries R, Oser M, Deng J, Diskin B, et al. CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer. Cancer Cell. 2019;: pubmed 出版商
Eremenko E, Mittal K, Berner O, Kamenetsky N, Nemirovsky A, Elyahu Y, et al. BDNF-producing, amyloid β-specific CD4 T cells as targeted drug-delivery vehicles in Alzheimer's disease. EBioMedicine. 2019;43:424-434 pubmed 出版商
Nagai Y, Ji M, Zhu F, Xiao Y, Tanaka Y, Kambayashi T, et al. PRMT5 Associates With the FOXP3 Homomer and When Disabled Enhances Targeted p185erbB2/neu Tumor Immunotherapy. Front Immunol. 2019;10:174 pubmed 出版商
Lorentsen K, Cho J, Luo X, Zuniga A, Urban J, Zhou L, et al. Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma. Nat Commun. 2018;9:1679 pubmed 出版商
产品信息
抗原 :
CD4
Apps. Abbrev. :
流式细胞仪
目录 :
100453
克隆 :
GK1.5
产品 :
亮紫色785™抗小鼠CD4
抗体亚型 :
Rat IgG2b, κ
其他名称 :
L3T4, T4
规格 :
50微克
价格(美元) :
273美元
反应物种 :
小鼠
克隆性 :
单克隆
宿主 :
大鼠
共轭标签/标签/标记 :
BV785
免疫原 :
小鼠CTL克隆V4
应用注释 :
Additional reported applications (for the relevant formats) include: blocking of CD4 + T cell activation 1,4,11 , thymocyte costimulation 3 , in vitro and in vivo depletion 2,5-8 , blocking of egg-sperm cell adhesion 1,4 , immunohistochemical staining of acetone-fixed frozen sections 9,10 , immunoprecipitation 1,2 , and spatial biology (IBEX) 12,13 . The GK1.5 antibody is able to block CD4 mediated cell adhesion and T cell activation. Binding of GK1.5 antibody to CD4 T cells can be blocked by RM4-5 antibody, but not RM4-4 antibody. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF purified antibody (Cat. No. 100442) with a lower endotoxin limit than standard LEAF purified antibodies (Endotoxin 0.01 EU/ug).
更多信息或购买 :
公司信息
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
1-858-455-9588
公司总部: 美国
Biolegend公司为生物医学研究提供顶级的抗体及试剂产品,旨在加速生命科学领域的研发工作。