产品简要
公司名称 :
BioLegend
其他品牌 :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
产品类型 :
抗体
产品名称 :
异硫氰酸荧光素抗小鼠CD4
目录 :
100510
规格 :
500微克
价格 :
99美元
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
异硫氰酸荧光素
克隆名称 :
RM4-5
反应物种 :
小鼠
应用 :
免疫组化, 流式细胞仪
更多信息或购买 :
文章摘录数: 84
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 1:200
James O, Vandereyken M, Marchingo J, Singh F, Bray S, Wilson J, et al. IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes. Nat Commun. 2021;12:4290 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 6f
Xia X, Li R, Zhou P, Xing Z, Lu C, Long Z, et al. Decreased NSG3 enhances PD-L1 expression by Erk1/2 pathway to promote pancreatic cancer progress. Am J Cancer Res. 2021;11:916-929 pubmed
  • 流式细胞仪; 小鼠; 1:250; 图 4g
  • 免疫组化; 小鼠; 图 2a
Bhaskar A, Kumar S, Khan M, Singh A, Dwivedi V, Nandicoori V. Host sirtuin 2 as an immunotherapeutic target against tuberculosis. elife. 2020;9: pubmed 出版商
  • 流式细胞仪; 小鼠; 1:200; 图 3a
Terashima Y, Toda E, Itakura M, Otsuji M, Yoshinaga S, Okumura K, et al. Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties. Nat Commun. 2020;11:609 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s16a
Schafflick D, Xu C, Hartlehnert M, Cole M, Schulte Mecklenbeck A, Lautwein T, et al. Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis. Nat Commun. 2020;11:247 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2c
Schanoski A, Le T, Kaiserman D, Rowe C, Prow N, Barboza D, et al. Granzyme A in Chikungunya and Other Arboviral Infections. Front Immunol. 2019;10:3083 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:100; 图 s2o
Lee J, Stone M, Porrett P, Thomas S, Komar C, Li J, et al. Hepatocytes direct the formation of a pro-metastatic niche in the liver. Nature. 2019;567:249-252 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:50; 图 s3d
Wheeler M, Jaronen M, Covacu R, Zandee S, Scalisi G, Rothhammer V, et al. Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation. Cell. 2019;176:581-596.e18 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 4a
Garić D, Tao S, Ahmed E, Youssef M, Kanagaratham C, Shah J, et al. Depletion of BAFF cytokine exacerbates infection in Pseudomonas aeruginosa infected mice. J Cyst Fibros. 2019;18:349-356 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s10e
Zhang J, Bu X, Wang H, Zhu Y, Geng Y, Nihira N, et al. Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. Nature. 2018;553:91-95 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s3b
Tripathi D, Venkatasubramanian S, Cheekatla S, Paidipally P, Welch E, Tvinnereim A, et al. A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice. Nat Commun. 2016;7:13896 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1a
Moodley D, Yoshida H, Mostafavi S, Asinovski N, Ortiz Lopez A, Symanowicz P, et al. Network pharmacology of JAK inhibitors. Proc Natl Acad Sci U S A. 2016;113:9852-7 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Qi X, Gurung P, Malireddi R, Karmaus P, Sharma D, Vogel P, et al. Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis. Mucosal Immunol. 2017;10:128-138 pubmed 出版商
  • 流式细胞仪; 小鼠
Ackerknecht M, Hauser M, Legler D, Stein J. In vivo TCR Signaling in CD4(+) T Cells Imprints a Cell-Intrinsic, Transient Low-Motility Pattern Independent of Chemokine Receptor Expression Levels, or Microtubular Network, Integrin, and Protein Kinase C Activity. Front Immunol. 2015;6:297 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s1
Suzuki H, Watari A, Hashimoto E, Yonemitsu M, Kiyono H, Yagi K, et al. C-Terminal Clostridium perfringens Enterotoxin-Mediated Antigen Delivery for Nasal Pneumococcal Vaccine. PLoS ONE. 2015;10:e0126352 pubmed 出版商
  • 流式细胞仪; 小鼠
Olguín J, Fernández J, Salinas N, Juárez I, Rodriguez Sosa M, Campuzano J, et al. Adoptive transfer of CD4(+)Foxp3(+) regulatory T cells to C57BL/6J mice during acute infection with Toxoplasma gondii down modulates the exacerbated Th1 immune response. Microbes Infect. 2015;17:586-95 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3
Chaimowitz N, Falanga Y, Ryan J, Conrad D. Fyn kinase is required for optimal humoral responses. PLoS ONE. 2013;8:e60640 pubmed 出版商
Chen L, Zhou C, Chen Q, Shang J, Liu Z, Guo Y, et al. Oncolytic Zika virus promotes intratumoral T cell infiltration and improves immunotherapy efficacy in glioblastoma. Mol Ther Oncolytics. 2022;24:522-534 pubmed 出版商
Repáraz D, Ruiz M, Llopiz D, Silva L, Vercher E, Aparicio B, et al. Neoantigens as potential vaccines in hepatocellular carcinoma. J Immunother Cancer. 2022;10: pubmed 出版商
Shiozawa S, Tsumiyama K, Miyazaki Y, Uto K, Sakurai K, Nakashima T, et al. DOCK8-expressing T follicular helper cells newly generated beyond self-organized criticality cause systemic lupus erythematosus. iScience. 2022;25:103537 pubmed 出版商
Li Y, Zhang N, Ma C, Xu W, Jin G, Zheng Y, et al. The overexpression of Tipe2 in CRC cells suppresses survival while endogenous Tipe2 accelerates AOM/DSS induced-tumor initiation. Cell Death Dis. 2021;12:1001 pubmed 出版商
Forni M, Domínguez Amorocho O, de Assis L, Kinker G, Moraes M, Castrucci A, et al. An Immunometabolic Shift Modulates Cytotoxic Lymphocyte Activation During Melanoma Progression in TRPA1 Channel Null Mice. Front Oncol. 2021;11:667715 pubmed 出版商
Christian L, Wang L, Lim B, Deng D, Wu H, Wang X, et al. Resident memory T cells in tumor-distant tissues fortify against metastasis formation. Cell Rep. 2021;35:109118 pubmed 出版商
Yi W, Zhang Y, Liu B, Zhou Y, Liao D, Qiao X, et al. Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration. Cell Rep. 2021;34:108922 pubmed 出版商
Delacher M, Simon M, Sanderink L, Hotz Wagenblatt A, Wuttke M, Schambeck K, et al. Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells. Immunity. 2021;54:702-720.e17 pubmed 出版商
Gonzalez Figueroa P, Roco J, Papa I, Núñez Villacís L, Stanley M, Linterman M, et al. Follicular regulatory T cells produce neuritin to regulate B cells. Cell. 2021;184:1775-1789.e19 pubmed 出版商
Zheng H, Zhang Y, Li L, Zhang R, Luo Z, Yang Z, et al. Depletion of Toll-Like Receptor-9 Attenuates Renal Tubulointerstitial Fibrosis After Ischemia-Reperfusion Injury. Front Cell Dev Biol. 2021;9:641527 pubmed 出版商
Yi M, Zhang J, Li A, Niu M, Yan Y, Jiao Y, et al. The construction, expression, and enhanced anti-tumor activity of YM101: a bispecific antibody simultaneously targeting TGF-β and PD-L1. J Hematol Oncol. 2021;14:27 pubmed 出版商
Zhou X, Zhu X, Li C, Li Y, Ye Z, Shapiro V, et al. Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity. Cell Rep. 2021;34:108601 pubmed 出版商
Zhang Y, Dong X, Bai L, Shang X, Zeng Y. MUC1-induced immunosuppression in colon cancer can be reversed by blocking the PD1/PDL1 signaling pathway. Oncol Lett. 2020;20:317 pubmed 出版商
Gong N, Zhang Y, Teng X, Wang Y, Huo S, Qing G, et al. Proton-driven transformable nanovaccine for cancer immunotherapy. Nat Nanotechnol. 2020;15:1053-1064 pubmed 出版商
Yang W, Yu T, Huang X, Bilotta A, Xu L, Lu Y, et al. Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity. Nat Commun. 2020;11:4457 pubmed 出版商
Helfricht A, Thijssen P, Rother M, Shah R, Du L, Takada S, et al. Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome. J Exp Med. 2020;217: pubmed 出版商
Van Den Eeckhout B, Van Hoecke L, Burg E, Van Lint S, Peelman F, Kley N, et al. Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant. NPJ Vaccines. 2020;5:64 pubmed 出版商
Lin H, Wang Q, Liu L, Chen Z, Das R, Zhao Y, et al. Colonization of Mice With Amoxicillin-Associated Klebsiella variicola Drives Inflammation via Th1 Induction and Treg Inhibition. Front Microbiol. 2020;11:1256 pubmed 出版商
Zhang Y, Chen C, Deng C, Zhang C, Li N, Wang Z, et al. A novel rabies vaccine based on infectious propagating particles derived from hybrid VEEV-Rabies replicon. EBioMedicine. 2020;56:102819 pubmed 出版商
Bao Z, Li J, Zhang P, Pan Q, Liu B, Zhu J, et al. Toll-Like Receptor 3 Activator Preconditioning Enhances Modulatory Function of Adipose‑Derived Mesenchymal Stem Cells in a Fully MHC-Mismatched Murine Model of Heterotopic Heart Transplantation. Ann Transplant. 2020;25:e921287 pubmed 出版商
Krotova K, Day A, Aslanidi G. An Engineered AAV6-Based Vaccine Induces High Cytolytic Anti-Tumor Activity by Directly Targeting DCs and Improves Ag Presentation. Mol Ther Oncolytics. 2019;15:166-177 pubmed 出版商
Jackstadt R, van Hooff S, Leach J, Cortés Lavaud X, Lohuis J, Ridgway R, et al. Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis. Cancer Cell. 2019;36:319-336.e7 pubmed 出版商
Misumi I, Cook K, Mitchell J, Lund M, Vick S, Lee R, et al. Identification of a Locus in Mice that Regulates the Collateral Damage and Lethality of Virus Infection. Cell Rep. 2019;27:1387-1396.e5 pubmed 出版商
Fachi J, Felipe J, Pral L, da Silva B, Corrêa R, de Andrade M, et al. Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism. Cell Rep. 2019;27:750-761.e7 pubmed 出版商
Srivastava S, Salter A, Liggitt D, Yechan Gunja S, Sarvothama M, Cooper K, et al. Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting. Cancer Cell. 2019;35:489-503.e8 pubmed 出版商
Zhou J, Peng H, Li K, Qu K, Wang B, Wu Y, et al. Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD-1-PD-L1 Axis. Immunity. 2019;50:403-417.e4 pubmed 出版商
Cantor D, King B, Blumenberg L, Dimauro T, Aifantis I, Koralov S, et al. Impaired Expression of Rearranged Immunoglobulin Genes and Premature p53 Activation Block B Cell Development in BMI1 Null Mice. Cell Rep. 2019;26:108-118.e4 pubmed 出版商
Zegarra Ruiz D, El Beidaq A, Iñiguez A, Lubrano Di Ricco M, Manfredo Vieira S, Ruff W, et al. A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity. Cell Host Microbe. 2019;25:113-127.e6 pubmed 出版商
Jin X, Ding D, Yan Y, Li H, Wang B, Ma L, et al. Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression. Mol Cell. 2019;73:22-35.e6 pubmed 出版商
Kyburz A, Fallegger A, Zhang X, Altobelli A, Artola Borán M, Borbet T, et al. Transmaternal Helicobacter pylori exposure reduces allergic airway inflammation in offspring through regulatory T cells. J Allergy Clin Immunol. 2019;143:1496-1512.e11 pubmed 出版商
Ogawa M, Inomata T, Shiang T, Tsubota K, Murakami A. Method for selective quantification of immune and inflammatory cells in the cornea using flow cytometry. J Biol Methods. 2018;5:e102 pubmed 出版商
Uchimura T, Oyama Y, Deng M, Guo H, Wilson J, Rampanelli E, et al. The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity. Immunity. 2018;49:1049-1061.e6 pubmed 出版商
Gilleron J, Bouget G, Ivanov S, Méziat C, Ceppo F, Vergoni B, et al. Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance. Cell Rep. 2018;25:3329-3341.e5 pubmed 出版商
Graham D, Luo C, O Connell D, Lefkovith A, Brown E, Yassour M, et al. Antigen discovery and specification of immunodominance hierarchies for MHCII-restricted epitopes. Nat Med. 2018;24:1762-1772 pubmed 出版商
Wan X, Zinselmeyer B, Zakharov P, Vomund A, Taniguchi R, Santambrogio L, et al. Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides. Nature. 2018;560:107-111 pubmed 出版商
Kim M, Galan C, Hill A, Wu W, Fehlner Peach H, Song H, et al. Critical Role for the Microbiota in CX3CR1+ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses. Immunity. 2018;49:151-163.e5 pubmed 出版商
Barry K, Hsu J, Broz M, Cueto F, Binnewies M, Combes A, et al. A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments. Nat Med. 2018;24:1178-1191 pubmed 出版商
Kagoya Y, Nakatsugawa M, Saso K, Guo T, Anczurowski M, Wang C, et al. DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models. Nat Commun. 2018;9:1915 pubmed 出版商
Uribe Herranz M, Bittinger K, Rafail S, Guedan S, Pierini S, Tanes C, et al. Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12. JCI Insight. 2018;3: pubmed 出版商
Wang L, Du F, Wang H, Xie C. Cooperation of CD4+ T cells and CD8+ T cells and release of IFN-γ are critical for antileukemia responses of recipient mice treated by microtransplantation. Exp Ther Med. 2018;15:1532-1537 pubmed 出版商
Burton O, Tamayo J, Stranks A, Miller S, Koleoglou K, Weinberg E, et al. IgE promotes type 2 innate lymphoid cells in murine food allergy. Clin Exp Allergy. 2017;: pubmed 出版商
Yuan X, Yang B, Dong Y, Yamamura A, Fu W. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells. elife. 2017;6: pubmed 出版商
Liao T, Xue Y, Zhao D, Li S, Liu M, Chen J, et al. In Vivo Attenuation of Antibody-Mediated Acute Renal Allograft Rejection by Ex Vivo TGF-?-Induced CD4+Foxp3+ Regulatory T Cells. Front Immunol. 2017;8:1334 pubmed 出版商
Yeon S, Halim L, Chandele A, Perry C, Kim S, Kim S, et al. IL-7 plays a critical role for the homeostasis of allergen-specific memory CD4 T cells in the lung and airways. Sci Rep. 2017;7:11155 pubmed 出版商
Kyburz A, Urban S, Altobelli A, Floess S, Huehn J, Cover T, et al. Helicobacter pylori and its secreted immunomodulator VacA protect against anaphylaxis in experimental models of food allergy. Clin Exp Allergy. 2017;47:1331-1341 pubmed 出版商
Papa I, Saliba D, Ponzoni M, Bustamante S, Canete P, Gonzalez Figueroa P, et al. TFH-derived dopamine accelerates productive synapses in germinal centres. Nature. 2017;547:318-323 pubmed 出版商
Xu C, Ruan B, Jiang Y, Xue T, Wang Z, Lu H, et al. Antibiotics-induced gut microbiota dysbiosis promotes tumor initiation via affecting APC-Th1 development in mice. Biochem Biophys Res Commun. 2017;488:418-424 pubmed 出版商
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产品信息
抗原 :
CD4
Apps. Abbrev. :
流式细胞仪
目录 :
100510
克隆 :
RM4-5
产品 :
异硫氰酸荧光素抗小鼠CD4
抗体亚型 :
Rat IgG2a, κ
其他名称 :
L3T4, T4
规格 :
500微克
价格(美元) :
99美元
反应物种 :
小鼠
克隆性 :
单克隆
宿主 :
大鼠
共轭标签/标签/标记 :
异硫氰酸荧光素
免疫原 :
BALB/c mouse thymocytes
应用注释 :
The RM4-5 antibody blocks the binding of GK1.5 antibody and H129.19 antibody to CD4 + T cells, but not RM4-4 antibody. Additional reported applications (for the relevant formats) include: blocking of ligand binding, in vivo depletion of CD4 + cells 1 , and immunohistochemistry of acetone-fixed frozen tissue sections 2,3,11 and paraffin-embedded sections 11 . Clone RM4-5 is not recommended for immunohistochemistry of formalin-fixed paraffin sections. Instead, acetone frozen or zinc-fixed paraffin sections are recommended. The Ultra-LEAF™ Purified antibody (Endotoxin 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 100575 and 100576 ).
更多信息或购买 :
公司信息
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
1-858-455-9588
公司总部: 美国
Biolegend公司为生物医学研究提供顶级的抗体及试剂产品,旨在加速生命科学领域的研发工作。