产品简要
公司名称 :
BioLegend
其他品牌 :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
产品类型 :
抗体
产品名称 :
异硫氰酸荧光素抗小鼠CD8a
目录 :
100705
规格 :
50微克
价格 :
30美元
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
异硫氰酸荧光素
克隆名称 :
53-6.7
反应物种 :
人类, 小鼠
应用 :
流式细胞仪
更多信息或购买 :
文章摘录数: 153
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 图 3
Kumagai Y, Futoh Y, Miyato H, Ohzawa H, Yamaguchi H, Saito S, et al. Effect of Systemic or Intraperitoneal Administration of Anti-PD-1 Antibody for Peritoneal Metastases from Gastric Cancer. In Vivo. 2022;36:1126-1135 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 6a
Xu P, Xiong W, Lin Y, Fan L, Pan H, Li Y. Histone deacetylase 2 knockout suppresses immune escape of triple-negative breast cancer cells via downregulating PD-L1 expression. Cell Death Dis. 2021;12:779 pubmed 出版商
  • 流式细胞仪; 小鼠
Winn N, Wolf E, Cottam M, Bhanot M, Hasty A. Myeloid-specific deletion of ferroportin impairs macrophage bioenergetics but is disconnected from systemic insulin action in adult mice. Am J Physiol Endocrinol Metab. 2021;321:E376-E391 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:200
Van De Velde L, Allen E, Crawford J, Wilson T, Guy C, Russier M, et al. Neuroblastoma Formation Requires Unconventional CD4 T Cells and Arginase-1-Dependent Myeloid Cells. Cancer Res. 2021;81:5047-5059 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3g
Zheng D, Gao F, Cheng Q, Bao P, Dong X, Fan J, et al. A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy. Nat Commun. 2020;11:1985 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s16d
Schafflick D, Xu C, Hartlehnert M, Cole M, Schulte Mecklenbeck A, Lautwein T, et al. Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis. Nat Commun. 2020;11:247 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 e2a, e5h
Strickley J, Messerschmidt J, Awad M, Li T, Hasegawa T, Ha D, et al. Immunity to commensal papillomaviruses protects against skin cancer. Nature. 2019;: pubmed 出版商
  • 流式细胞仪; 小鼠; 1:100; 图 e7b
Dulken B, Buckley M, Navarro Negredo P, Saligrama N, Cayrol R, Leeman D, et al. Single-cell analysis reveals T cell infiltration in old neurogenic niches. Nature. 2019;571:205-210 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s2a
Martins J, Andoniou C, Fleming P, Kuns R, Schuster I, Voigt V, et al. Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation. Science. 2019;363:288-293 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2a
Ishizuka J, Manguso R, Cheruiyot C, Bi K, Panda A, Iracheta Vellve A, et al. Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade. Nature. 2019;565:43-48 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s1a
Han Y, Liu Q, Hou J, Gu Y, Zhang Y, Chen Z, et al. Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression. Cell. 2018;173:634-648.e12 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1b
Hu Y, Kim J, He K, Wan Q, Kim J, Flach M, et al. Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion. J Exp Med. 2016;213:2759-2772 pubmed
  • 流式细胞仪; 小鼠; 1:400; 图 2a
Starobinets H, Ye J, Broz M, Barry K, Goldsmith J, Marsh T, et al. Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment. J Clin Invest. 2016;126:4417-4429 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Huang M, Zhang W, Guo J, Wei X, Phiwpan K, Zhang J, et al. Improved Transgenic Mouse Model for Studying HLA Class I Antigen Presentation. Sci Rep. 2016;6:33612 pubmed 出版商
  • 流式细胞仪; 人类; 1:100
Lu X, Chen Q, Rong Y, Yang G, Li C, Xu N, et al. LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells. Nat Commun. 2016;7:12719 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5
Li Y, Nishikawa T, Kaneda Y. Platelet-cytokine Complex Suppresses Tumour Growth by Exploiting Intratumoural Thrombin-dependent Platelet Aggregation. Sci Rep. 2016;6:25077 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 4
Yasuma K, Yasunaga J, Takemoto K, Sugata K, Mitobe Y, Takenouchi N, et al. HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT). PLoS Pathog. 2016;12:e1005372 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5
Venkatasubramanian S, Tripathi D, Tucker T, Paidipally P, Cheekatla S, Welch E, et al. Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection. Eur J Immunol. 2016;46:464-79 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:5000; 图 4
Matsuda T, Yanase S, Takaoka A, Maruyama M. The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation. Immun Ageing. 2015;12:1 pubmed 出版商
  • 流式细胞仪; 小鼠
Drees J, Mertensotto M, Liu G, Panyam J, Leonard A, Augustin L, et al. Attenuated Salmonella enterica Typhimurium reduces tumor burden in an autochthonous breast cancer model. Anticancer Res. 2015;35:843-9 pubmed
  • 流式细胞仪; 小鼠; 1:200
Maneva Radicheva L, Amatya C, Parker C, Ellefson J, Radichev I, Raghavan A, et al. Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1. PLoS ONE. 2014;9:e107213 pubmed 出版商
  • 流式细胞仪; 小鼠
Kitagawa K, Shibata K, Matsumoto A, Matsumoto M, Ohhata T, Nakayama K, et al. Fbw7 targets GATA3 through cyclin-dependent kinase 2-dependent proteolysis and contributes to regulation of T-cell development. Mol Cell Biol. 2014;34:2732-44 pubmed
Leary N, Walser S, He Y, Cousin N, Pereira P, Gallo A, et al. Melanoma-derived extracellular vesicles mediate lymphatic remodelling and impair tumour immunity in draining lymph nodes. J Extracell Vesicles. 2022;11:e12197 pubmed 出版商
Wang Y, Wei B, Wang D, Wu J, Gao J, Zhong H, et al. DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis. Acta Pharm Sin B. 2022;12:262-273 pubmed 出版商
Sun C, Fujisawa M, Ohara T, Liu Q, Cao C, Yang X, et al. Spred2 controls the severity of Concanavalin A-induced liver damage by limiting interferon-gamma production by CD4+ and CD8+ T cells. J Adv Res. 2022;35:71-86 pubmed 出版商
Song X, Li N, Liu Y, Wang Z, Wang T, Tan S, et al. CD169-positive macrophages enhance abscopal effect of radiofrequency ablation therapy in liver cancer. Transl Oncol. 2022;15:101306 pubmed 出版商
Dodagatta Marri E, Ma H, Liang B, Li J, Meyer D, Chen S, et al. Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy. Cell Rep. 2021;36:109309 pubmed 出版商
Volberding P, Xin G, Kasmani M, Khatun A, Brown A, Nguyen C, et al. Suppressive neutrophils require PIM1 for metabolic fitness and survival during chronic viral infection. Cell Rep. 2021;35:109160 pubmed 出版商
Altshuler A, Amitai Lange A, Tarazi N, Dey S, Strinkovsky L, Hadad Porat S, et al. Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing. Cell Stem Cell. 2021;28:1248-1261.e8 pubmed 出版商
Vaena S, Chakraborty P, Lee H, Janneh A, Kassir M, Beeson G, et al. Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response. Cell Rep. 2021;35:109076 pubmed 出版商
Lutes L, Steier Z, McIntyre L, Pandey S, Kaminski J, Hoover A, et al. T cell self-reactivity during thymic development dictates the timing of positive selection. elife. 2021;10: pubmed 出版商
Mitchell J, Lund M, Starmer J, Ge K, Magnuson T, Shpargel K, et al. UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability. Cell Rep. 2021;35:108966 pubmed 出版商
Tacconi C, Commerford C, Dieterich L, Schwager S, He Y, Ikenberg K, et al. CD169+ lymph node macrophages have protective functions in mouse breast cancer metastasis. Cell Rep. 2021;35:108993 pubmed 出版商
Yi W, Zhang Y, Liu B, Zhou Y, Liao D, Qiao X, et al. Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration. Cell Rep. 2021;34:108922 pubmed 出版商
Delacher M, Simon M, Sanderink L, Hotz Wagenblatt A, Wuttke M, Schambeck K, et al. Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells. Immunity. 2021;54:702-720.e17 pubmed 出版商
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Chen R, Okeyo Owuor T, Patel R, Casey E, Cluster A, Yang W, et al. Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy. Cell Rep. 2021;34:108751 pubmed 出版商
Trefzer A, Kadam P, Wang S, Pennavaria S, Lober B, Akçabozan B, et al. Dynamic adoption of anergy by antigen-exhausted CD4+ T cells. Cell Rep. 2021;34:108748 pubmed 出版商
Shen J, Qiu Z, Wu Q, Finlay D, Garcia G, Sun D, et al. FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells. Cell. 2021;184:352-369.e23 pubmed 出版商
Lv H, Lv G, Chen C, Zong Q, Jiang G, Ye D, et al. NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion. Cell Metab. 2021;33:110-127.e5 pubmed 出版商
Li X, Zhang M, Huang X, Liang W, Li G, Lu X, et al. Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners. Nat Commun. 2020;11:6364 pubmed 出版商
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León Letelier R, Castro Medina D, Badillo Godinez O, Tepale Segura A, Huanosta Murillo E, Aguilar Flores C, et al. Induction of Progenitor Exhausted Tissue-Resident Memory CD8+ T Cells Upon Salmonella Typhi Porins Adjuvant Immunization Correlates With Melanoma Control and Anti-PD-1 Immunotherapy Cooperation. Front Immunol. 2020;11:583382 pubmed 出版商
Zhang Y, Dong X, Bai L, Shang X, Zeng Y. MUC1-induced immunosuppression in colon cancer can be reversed by blocking the PD1/PDL1 signaling pathway. Oncol Lett. 2020;20:317 pubmed 出版商
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Xie Z, Peng M, Lu R, Meng X, Liang W, Li Z, et al. Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy. Light Sci Appl. 2020;9:161 pubmed 出版商
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Liu W, Dai E, Liu Z, Ma C, Guo Z, Bartlett D. In Situ Therapeutic Cancer Vaccination with an Oncolytic Virus Expressing Membrane-Tethered IL-2. Mol Ther Oncolytics. 2020;17:350-360 pubmed 出版商
Zhi Y, Lin S, Ahn K, Ji H, Guo H, Ryu S, et al. ptsI gene in the phosphotransfer system is a potential target for developing a live attenuated Salmonella vaccine. Int J Mol Med. 2020;45:1327-1340 pubmed 出版商
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Lee H, Lee Y, Harenda Q, Pietrzak S, Oktay H, Schreiber S, et al. Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes. Cell Metab. 2020;31:822-836.e5 pubmed 出版商
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Fu S, He K, Tian C, Sun H, Zhu C, Bai S, et al. Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells. Nat Commun. 2020;11:438 pubmed 出版商
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Raju S, Verbaro D, Egawa T. PD-1 Signaling Promotes Control of Chronic Viral Infection by Restricting Type-I-Interferon-Mediated Tissue Damage. Cell Rep. 2019;29:2556-2564.e3 pubmed 出版商
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Sivapatham S, Ficht X, Barreto de Albuquerque J, Page N, Merkler D, Stein J. Initial Viral Inoculum Determines Kinapse-and Synapse-Like T Cell Motility in Reactive Lymph Nodes. Front Immunol. 2019;10:2086 pubmed 出版商
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Kim J, Lim I, Joo H, Park C, Choi S, Jeong H, et al. Fimasartan reduces neointimal formation and inflammation after carotid arterial injury in apolipoprotein E knockout mice. Mol Med. 2019;25:33 pubmed 出版商
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Royzman D, Andreev D, Stich L, Rauh M, Bauerle T, Ellmann S, et al. Soluble CD83 Triggers Resolution of Arthritis and Sustained Inflammation Control in IDO Dependent Manner. Front Immunol. 2019;10:633 pubmed 出版商
Fleskens V, Minutti C, Wu X, Wei P, Pals C, McCrae J, et al. Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells. Cell Rep. 2019;26:3600-3612.e6 pubmed 出版商
Srivastava S, Salter A, Liggitt D, Yechan Gunja S, Sarvothama M, Cooper K, et al. Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting. Cancer Cell. 2019;35:489-503.e8 pubmed 出版商
Yang H, Xie T, Li D, Du X, Wang T, Li C, et al. Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-κB/TNF-α pathway. Mol Metab. 2019;23:24-36 pubmed 出版商
Denny J, Powers J, Castro H, Zhang J, Joshi Barve S, Campagna S, et al. Differential Sensitivity to Plasmodium yoelii Infection in C57BL/6 Mice Impacts Gut-Liver Axis Homeostasis. Sci Rep. 2019;9:3472 pubmed 出版商
Liu J, Zhang X, Chen K, Cheng Y, Liu S, Xia M, et al. CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis. Immunity. 2019;50:600-615.e15 pubmed 出版商
Zhang F, Li R, Yang Y, Shi C, Shen Y, Lu C, et al. Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses. Immunity. 2019;50:738-750.e7 pubmed 出版商
Treger R, Pope S, Kong Y, Tokuyama M, Taura M, Iwasaki A. The Lupus Susceptibility Locus Sgp3 Encodes the Suppressor of Endogenous Retrovirus Expression SNERV. Immunity. 2019;50:334-347.e9 pubmed 出版商
Xiao P, Zhang H, Zhang Y, Zheng M, Liu R, Zhao Y, et al. Phosphatase Shp2 exacerbates intestinal inflammation by disrupting macrophage responsiveness to interleukin-10. J Exp Med. 2019;216:337-349 pubmed 出版商
Ren S, Chen X, Huang R, Zhou G, Yuan Z. SOCS4 expressed by recombinant HSV protects against cytokine storm in a mouse model. Oncol Rep. 2019;41:1509-1520 pubmed 出版商
Uchimura T, Oyama Y, Deng M, Guo H, Wilson J, Rampanelli E, et al. The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity. Immunity. 2018;49:1049-1061.e6 pubmed 出版商
Ibrahim M, Klement J, Lu C, Redd P, Xiao W, Yang D, et al. Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis. Cell Rep. 2018;25:3036-3046.e6 pubmed 出版商
Wu B, Zhang S, Guo Z, Wang G, Zhang G, Xie L, et al. RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T-Helper-2-Cell-Biased Programs. Immunity. 2018;49:886-898.e5 pubmed 出版商
Gotoh K, Morisaki T, Setoyama D, Sasaki K, Yagi M, Igami K, et al. Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation. Cell Rep. 2018;25:1800-1815.e4 pubmed 出版商
Edgar L, Kawasaki N, Nycholat C, Paulson J. Targeted Delivery of Antigen to Activated CD169+ Macrophages Induces Bias for Expansion of CD8+ T Cells. Cell Chem Biol. 2019;26:131-136.e4 pubmed 出版商
Sade Feldman M, Yizhak K, Bjorgaard S, Ray J, de Boer C, Jenkins R, et al. Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma. Cell. 2018;175:998-1013.e20 pubmed 出版商
Tao Z, McCall N, Wiedemann N, Vuagniaux G, Yuan Z, Lu B. SMAC Mimetic Debio 1143 and Ablative Radiation Therapy Synergize to Enhance Antitumor Immunity against Lung Cancer. Clin Cancer Res. 2019;25:1113-1124 pubmed 出版商
Bartolacci C, Andreani C, Curcio C, Occhipinti S, Massaccesi L, Giovarelli M, et al. Phage-Based Anti-HER2 Vaccination Can Circumvent Immune Tolerance against Breast Cancer. Cancer Immunol Res. 2018;6:1486-1498 pubmed 出版商
Du J, Ding X, Zhang X, Zhao X, Shan H, Wang F. Berberine attenuate staphylococcal enterotoxin B-mediated acute liver injury via regulating HDAC expression. AMB Express. 2018;8:158 pubmed 出版商
Xia Y, Xie Y, Yu Z, Xiao H, Jiang G, Zhou X, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018;175:1059-1073.e21 pubmed 出版商
Golan K, Kumari A, Kollet O, Khatib Massalha E, Subramaniam M, Ferreira Z, et al. Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance. Cell Stem Cell. 2018;23:572-585.e7 pubmed 出版商
Urata S, Kenyon E, Nayak D, Cubitt B, Kurosaki Y, Yasuda J, et al. BST-2 controls T cell proliferation and exhaustion by shaping the early distribution of a persistent viral infection. PLoS Pathog. 2018;14:e1007172 pubmed 出版商
Wan X, Zinselmeyer B, Zakharov P, Vomund A, Taniguchi R, Santambrogio L, et al. Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides. Nature. 2018;560:107-111 pubmed 出版商
Webster P, Dawes J, Dewchand H, Takacs K, Iadarola B, Bolt B, et al. Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates. Nat Commun. 2018;9:2649 pubmed 出版商
Kim Y, Son A, Kim J, Kwon S, Kim M, Kim P, et al. Chaperna-Mediated Assembly of Ferritin-Based Middle East Respiratory Syndrome-Coronavirus Nanoparticles. Front Immunol. 2018;9:1093 pubmed 出版商
Porrello A, Leslie P, Harrison E, Gorentla B, Kattula S, Ghosh S, et al. Factor XIIIA-expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking. Nat Commun. 2018;9:1988 pubmed 出版商
Smith L, Boukhaled G, Condotta S, Mazouz S, Guthmiller J, Vijay R, et al. Interleukin-10 Directly Inhibits CD8+ T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity. Immunity. 2018;48:299-312.e5 pubmed 出版商
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产品信息
抗原 :
CD8a
Apps. Abbrev. :
流式细胞仪
目录 :
100705
克隆 :
53-6.7
产品 :
异硫氰酸荧光素抗小鼠CD8a
抗体亚型 :
Rat IgG2a, κ
其他名称 :
T8, Lyt2, Ly-2
规格 :
50微克
价格(美元) :
30美元
反应物种 :
小鼠
克隆性 :
单克隆
宿主 :
大鼠
共轭标签/标签/标记 :
异硫氰酸荧光素
免疫原 :
小鼠胸腺或脾脏
应用注释 :
Clone 53-6.7 antibody competes with clone 5H10-1 antibody for binding to thymocytes 3 . The 53-6.7 antibody has been reported to block antigen presentation via MHC class I and inhibit T cell responses to IL-2. This antibody has also been used for depletion of CD8a + cells. Additional reported applications (for the relevant formats) include: immunoprecipitation 1,3 , in vivo and in vitro cell depletion 2,10,15 , inhibition of CD8 T cell proliferation 3 , blocking of cytotoxicity 3,4 , immunohistochemical staining 5,6 of acetone-fixed frozen sections and zinc-fixed paraffin-embedded sections, and spatial biology (IBEX) 29,30 . Clone 53-6.7 is not recommended for immunohistochemistry of formalin-fixed paraffin sections. The Ultra-LEAF purified antibody (Endotoxin 0.01 EU/ug, Azide-Free, 0.2 um filtered) is recommended for functional assays or in vivo studies (Cat No. 100746).
更多信息或购买 :
公司信息
BioLegend
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San Diego, CA 92121
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https://www.biolegend.com
1-858-455-9588
公司总部: 美国
Biolegend公司为生物医学研究提供顶级的抗体及试剂产品,旨在加速生命科学领域的研发工作。