产品简要
公司名称 :
BioLegend
其他品牌 :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
产品类型 :
抗体
产品名称 :
纯化抗小鼠CD28
目录 :
102101
规格 :
50微克
价格 :
45美元
克隆性 :
单克隆
宿主 :
Syrian golden hamster
共轭标签 :
未共轭
克隆名称 :
37.51
反应物种 :
人类, 小鼠
应用 :
酶联免疫吸附测定, 中和反应, 免疫沉淀, 流式细胞仪, 免疫组化-冰冻切片, 抑制或激活实验
更多信息或购买 :
文章摘录数: 72
出版应用/物种/样本/稀释参考文献
  • 抑制或激活实验; 小鼠; 1 ug/ml; 图 1h
Chen H, Cong X, Wu C, Wu X, Wang J, Mao K, et al. Intratumoral delivery of CCL25 enhances immunotherapy against triple-negative breast cancer by recruiting CCR9+ T cells. Sci Adv. 2020;6:eaax4690 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1b
Humeniuk P, Geiselhart S, Battin C, Webb T, Steinberger P, Paster W, et al. Generation of a Jurkat-based fluorescent reporter cell line to evaluate lipid antigen interaction with the human iNKT cell receptor. Sci Rep. 2019;9:7426 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 s8a
Singh A, Khare P, Obaid A, Conlon K, Basrur V, Depinho R, et al. SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2. Nat Commun. 2018;9:4515 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 5a
Fu G, Xu Q, Qiu Y, Jin X, Xu T, Dong S, et al. Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. J Exp Med. 2017;214:1453-1469 pubmed 出版商
  • 抑制或激活实验; 小鼠; 2 ug/ml; 图 3b
González Pérez G, Lamousé Smith E. Gastrointestinal Microbiome Dysbiosis in Infant Mice Alters Peripheral CD8+ T Cell Receptor Signaling. Front Immunol. 2017;8:265 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 5c
Klein J, Moses K, Zelinskyy G, Sody S, Buer J, Lang S, et al. Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth. Nat Commun. 2017;8:14600 pubmed 出版商
  • 流式细胞仪; 小鼠; 5 ug/ml; 图 4A
Troegeler A, Mercier I, Cougoule C, Pietretti D, Colom A, Duval C, et al. C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells. Proc Natl Acad Sci U S A. 2017;114:E540-E549 pubmed 出版商
  • 抑制或激活实验; 小鼠; 5 ug/ml
Bieber K, Witte M, Sun S, Hundt J, Kalies K, Dräger S, et al. T cells mediate autoantibody-induced cutaneous inflammation and blistering in epidermolysis bullosa acquisita. Sci Rep. 2016;6:38357 pubmed 出版商
  • 酶联免疫吸附测定; 小鼠
Cecchinato V, Bernasconi E, Speck R, Proietti M, Sauermann U, D Agostino G, et al. Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization. J Immunol. 2017;198:184-195 pubmed
  • 抑制或激活实验; 小鼠; 图 5a
Ishikura S, Tsunoda T, Nakabayashi K, Doi K, Koyanagi M, Hayashi K, et al. Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein Zfat in T cells. Biochim Biophys Acta. 2016;1859:1398-1410 pubmed 出版商
  • 抑制或激活实验; 小鼠; 2 ug/ml; 图 2a
Contreras F, Prado C, Gonzalez H, Franz D, Osorio Barrios F, Osorio F, et al. Dopamine Receptor D3 Signaling on CD4+ T Cells Favors Th1- and Th17-Mediated Immunity. J Immunol. 2016;196:4143-9 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 3
Apostolidis S, Rodríguez Rodríguez N, Suárez Fueyo A, Dioufa N, Ozcan E, Crispín J, et al. Phosphatase PP2A is requisite for the function of regulatory T cells. Nat Immunol. 2016;17:556-64 pubmed 出版商
  • 抑制或激活实验; 小鼠
Hwang S, Jang S, Kim M, Kim L, Kim B, Kim H, et al. YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity. Nat Commun. 2016;7:10789 pubmed 出版商
  • 抑制或激活实验; 人类; 图 1
McCully M, Collins P, Hughes T, Thomas C, Billen J, O Donnell V, et al. Skin Metabolites Define a New Paradigm in the Localization of Skin Tropic Memory T Cells. J Immunol. 2015;195:96-104 pubmed 出版商
  • 免疫沉淀; 小鼠
Richardson E, Shukla S, Sweet D, Wearsch P, Tsichlis P, Boom W, et al. Toll-like receptor 2-dependent extracellular signal-regulated kinase signaling in Mycobacterium tuberculosis-infected macrophages drives anti-inflammatory responses and inhibits Th1 polarization of responding T cells. Infect Immun. 2015;83:2242-54 pubmed 出版商
  • 抑制或激活实验; 小鼠; 2 ug/ml
Rao E, Zhang Y, Zhu G, Hao J, Persson X, Egilmez N, et al. Deficiency of AMPK in CD8+ T cells suppresses their anti-tumor function by inducing protein phosphatase-mediated cell death. Oncotarget. 2015;6:7944-58 pubmed
  • 抑制或激活实验; 小鼠; 20 ug/ml; 图 1
Fos C, Bécart S, Canonigo Balancio A, Boehning D, Altman A. Association of the EF-hand and PH domains of the guanine nucleotide exchange factor SLAT with IP₃ receptor 1 promotes Ca²⁺ signaling in T cells. Sci Signal. 2014;7:ra93 pubmed 出版商
  • 抑制或激活实验; 小鼠
Nancy P, Tagliani E, Tay C, Asp P, Levy D, Erlebacher A. Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface. Science. 2012;336:1317-21 pubmed 出版商
Khan K, Ponce de León J, Benguigui M, Xu P, Chow A, Cruz Munoz W, et al. Immunostimulatory and anti-tumor metronomic cyclophosphamide regimens assessed in primary orthotopic and metastatic murine breast cancer. NPJ Breast Cancer. 2020;6:29 pubmed 出版商
Rosenberg J, Cao G, Borja Prieto F, Huang J. Lattice Light-Sheet Microscopy Multi-dimensional Analyses (LaMDA) of T-Cell Receptor Dynamics Predict T-Cell Signaling States. Cell Syst. 2020;10:433-444.e5 pubmed 出版商
Rao T, Kumar S, Pulikkottil A, Oliveri F, Hendriks R, Beckel F, et al. Novel, Non-Gene-Destructive Knock-In Reporter Mice Refute the Concept of Monoallelic Gata3 Expression. J Immunol. 2020;204:2600-2611 pubmed 出版商
Cohen M, Zhang S, Sengupta S, Ma H, Bell G, Horton B, et al. Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras. Cell Stem Cell. 2020;26:579-592.e6 pubmed 出版商
Thumkeo D, Katsura Y, Nishimura Y, Kanchanawong P, Tohyama K, Ishizaki T, et al. mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse. Sci Adv. 2020;6:eaay2432 pubmed 出版商
Hawse W, Cattley R, Wendell S. Cutting Edge: TCR Signal Strength Regulates Acetyl-CoA Metabolism via AKT. J Immunol. 2019;203:2771-2775 pubmed 出版商
Krovi S, Kappler J, Marrack P, Gapin L. Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules. Proc Natl Acad Sci U S A. 2019;116:22252-22261 pubmed 出版商
Rasoulouniriana D, Santana Magal N, Gutwillig A, Farhat Younis L, Wine Y, Saperia C, et al. A distinct subset of FcγRI-expressing Th1 cells exert antibody-mediated cytotoxic activity. J Clin Invest. 2019;129:4151-4164 pubmed 出版商
Akiyama C, Tsumiyama K, Uchimura C, Honda E, Miyazaki Y, Sakurai K, et al. Conditional Upregulation of IFN-α Alone Is Sufficient to Induce Systemic Lupus Erythematosus. J Immunol. 2019;203:835-843 pubmed 出版商
Katagiri T, Yamazaki S, Fukui Y, Aoki K, Yagita H, Nishina T, et al. JunB plays a crucial role in development of regulatory T cells by promoting IL-2 signaling. Mucosal Immunol. 2019;12:1104-1117 pubmed 出版商
Niven J, Madelon N, Page N, Caruso A, Harlé G, Lemeille S, et al. Macroautophagy in Dendritic Cells Controls the Homeostasis and Stability of Regulatory T Cells. Cell Rep. 2019;28:21-29.e6 pubmed 出版商
Oghumu S, Varikuti S, Stock J, Volpedo G, Saljoughian N, Terrazas C, et al. Cutting Edge: CXCR3 Escapes X Chromosome Inactivation in T Cells during Infection: Potential Implications for Sex Differences in Immune Responses. J Immunol. 2019;203:789-794 pubmed 出版商
Racioppi L, Nelson E, Huang W, Mukherjee D, Lawrence S, Lento W, et al. CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer. Nat Commun. 2019;10:2450 pubmed 出版商
Komuczki J, Tuzlak S, Friebel E, Hartwig T, Spath S, Rosenstiel P, et al. Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β. Immunity. 2019;: pubmed 出版商
Cross E, Blain T, Mathew D, Kedl R. Anti-CD8 monoclonal antibody-mediated depletion alters the phenotype and behavior of surviving CD8+ T cells. PLoS ONE. 2019;14:e0211446 pubmed 出版商
Miret J, Kirschmeier P, Koyama S, Zhu M, Li Y, Naito Y, et al. Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity. J Immunother Cancer. 2019;7:32 pubmed 出版商
Hanoteau A, Newton J, Krupar R, Huang C, Liu H, Gaspero A, et al. Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy. J Immunother Cancer. 2019;7:10 pubmed 出版商
Yamada T, Nabe S, Toriyama K, Suzuki J, Inoue K, Imai Y, et al. Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8+ T Cells. J Immunol. 2019;202:1088-1098 pubmed 出版商
Patterson A, Bolcas P, Lampe K, Cantrell R, Ruff B, Lewkowich I, et al. Loss of GTPase of immunity-associated protein 5 (Gimap5) promotes pathogenic CD4+ T-cell development and allergic airway disease. J Allergy Clin Immunol. 2019;143:245-257.e6 pubmed 出版商
Sanctuary M, Huang R, Jones A, Luck M, Aherne C, Jedlicka P, et al. miR-106a deficiency attenuates inflammation in murine IBD models. Mucosal Immunol. 2019;12:200-211 pubmed 出版商
Simula L, Pacella I, Colamatteo A, Procaccini C, Cancila V, Bordi M, et al. Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming. Cell Rep. 2018;25:3059-3073.e10 pubmed 出版商
Sekiya T, Hibino S, Saeki K, Kanamori M, Takaki S, Yoshimura A. Nr4a Receptors Regulate Development and Death of Labile Treg Precursors to Prevent Generation of Pathogenic Self-Reactive Cells. Cell Rep. 2018;24:1627-1638.e6 pubmed 出版商
Hao Y, Wang Y, Liu X, Yang X, Wang P, Tian Q, et al. The Kinase Complex mTOR Complex 2 Promotes the Follicular Migration and Functional Maturation of Differentiated Follicular Helper CD4+ T Cells During Viral Infection. Front Immunol. 2018;9:1127 pubmed 出版商
Stelekati E, Chen Z, Manne S, Kurachi M, Ali M, Lewy K, et al. Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155. Cell Rep. 2018;23:2142-2156 pubmed 出版商
Lee J, Kim J, Yi J, Kim D, Kim H, Han D, et al. Phenotypic and Functional Changes of Peripheral Ly6C+ T Regulatory Cells Driven by Conventional Effector T Cells. Front Immunol. 2018;9:437 pubmed 出版商
Doorduijn E, Sluijter M, Querido B, Seidel U, Oliveira C, van der Burg S, et al. T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1b with TAP-Independent Peptides Are Semi-Invariant Lymphocytes. Front Immunol. 2018;9:60 pubmed 出版商
Tritama E, Riani C, Rudiansyah I, Hidayat A, Kharisnaeni S, Retnoningrum D. Evaluation of alum-based adjuvant on the immunogenicity of salmonella enterica serovar typhi conjugates vaccines. Hum Vaccin Immunother. 2018;14:1524-1529 pubmed 出版商
Kitamura T, Doughty Shenton D, Cassetta L, Fragkogianni S, Brownlie D, Kato Y, et al. Monocytes Differentiate to Immune Suppressive Precursors of Metastasis-Associated Macrophages in Mouse Models of Metastatic Breast Cancer. Front Immunol. 2017;8:2004 pubmed 出版商
Palazon A, Tyrakis P, Macías D, Veliça P, Rundqvist H, Fitzpatrick S, et al. An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression. Cancer Cell. 2017;32:669-683.e5 pubmed 出版商
Abe Y, Nambu A, Yamaguchi S, Takamori A, Suto H, Hirose S, et al. Role of interleukin-25 in development of spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice. Biochem Biophys Rep. 2017;12:62-65 pubmed 出版商
Xu L, Huang Q, Wang H, Hao Y, Bai Q, Hu J, et al. The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells. Immunity. 2017;47:538-551.e5 pubmed 出版商
Oh H, Grinberg Bleyer Y, Liao W, Maloney D, Wang P, Wu Z, et al. An NF-?B Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function. Immunity. 2017;47:450-465.e5 pubmed 出版商
Grinberg Bleyer Y, Oh H, Desrichard A, Bhatt D, Caron R, Chan T, et al. NF-?B c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. 2017;170:1096-1108.e13 pubmed 出版商
Link M, Lücke K, Schmid J, Schumacher V, Eden T, Rose John S, et al. The role of ADAM17 in the T-cell response against bacterial pathogens. PLoS ONE. 2017;12:e0184320 pubmed 出版商
Scholz T, Weigert A, Brüne B, Sadik C, Böhm B, Burkhardt H. GM-CSF in murine psoriasiform dermatitis: Redundant and pathogenic roles uncovered by antibody-induced neutralization and genetic deficiency. PLoS ONE. 2017;12:e0182646 pubmed 出版商
Liang J, Lyu J, Zhao M, Li D, Zheng M, Fang Y, et al. Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors. Nat Commun. 2017;8:15732 pubmed 出版商
Shimokawa C, Kanaya T, Hachisuka M, Ishiwata K, Hisaeda H, Kurashima Y, et al. Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections. Immunity. 2017;46:863-874.e4 pubmed 出版商
Majchrzak K, Nelson M, Bowers J, Bailey S, Wyatt M, Wrangle J, et al. β-catenin and PI3Kδ inhibition expands precursor Th17 cells with heightened stemness and antitumor activity. JCI Insight. 2017;2: pubmed 出版商
Schiering C, Wincent E, Metidji A, Iseppon A, Li Y, Potocnik A, et al. Feedback control of AHR signalling regulates intestinal immunity. Nature. 2017;542:242-245 pubmed 出版商
Tuzlak S, Schenk R, Vasanthakumar A, Preston S, Haschka M, Zotos D, et al. The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection. Cell Death Differ. 2017;24:523-533 pubmed 出版商
Plaza Sirvent C, Schuster M, Neumann Y, Heise U, Pils M, Schulze Osthoff K, et al. c-FLIP Expression in Foxp3-Expressing Cells Is Essential for Survival of Regulatory T Cells and Prevention of Autoimmunity. Cell Rep. 2017;18:12-22 pubmed 出版商
Hollmann C, Werner S, Avota E, Reuter D, Japtok L, Kleuser B, et al. Inhibition of Acid Sphingomyelinase Allows for Selective Targeting of CD4+ Conventional versus Foxp3+ Regulatory T Cells. J Immunol. 2016;197:3130-3141 pubmed
Kim K, Kim N, Lee G. Transcription Factors Oct-1 and GATA-3 Cooperatively Regulate Th2 Cytokine Gene Expression via the RHS5 within the Th2 Locus Control Region. PLoS ONE. 2016;11:e0148576 pubmed 出版商
Endo Y, Asou H, Matsugae N, Hirahara K, Shinoda K, Tumes D, et al. Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1. Cell Rep. 2015;12:1042-55 pubmed 出版商
Blankenhaus B, Reitz M, Brenz Y, Eschbach M, Hartmann W, Haben I, et al. Foxp3? regulatory T cells delay expulsion of intestinal nematodes by suppression of IL-9-driven mast cell activation in BALB/c but not in C57BL/6 mice. PLoS Pathog. 2014;10:e1003913 pubmed 出版商
Li C, Mueller E, Bradley L. Islet antigen-specific Th17 cells can induce TNF-?-dependent autoimmune diabetes. J Immunol. 2014;192:1425-32 pubmed 出版商
Crispin J, Apostolidis S, Rosetti F, Keszei M, Wang N, Terhorst C, et al. Cutting edge: protein phosphatase 2A confers susceptibility to autoimmune disease through an IL-17-dependent mechanism. J Immunol. 2012;188:3567-71 pubmed 出版商
Cunningham N, Hinchcliff E, Kutyavin V, Beck T, Reid W, Punt J. GSK3-mediated instability of tubulin polymers is responsible for the failure of immature CD4+CD8+ thymocytes to polarize their MTOC in response to TCR stimulation. Int Immunol. 2011;23:693-700 pubmed 出版商
Milpied P, Massot B, Renand A, Diem S, Herbelin A, Leite de Moraes M, et al. IL-17-producing invariant NKT cells in lymphoid organs are recent thymic emigrants identified by neuropilin-1 expression. Blood. 2011;118:2993-3002 pubmed 出版商
Rosenberger C, Clark A, Treuting P, Johnson C, Aderem A. ATF3 regulates MCMV infection in mice by modulating IFN-gamma expression in natural killer cells. Proc Natl Acad Sci U S A. 2008;105:2544-9 pubmed 出版商
Perchonock C, Pajerowski A, Nguyen C, Shapiro M, Shapiro V. The related adaptors, adaptor in lymphocytes of unknown function X and Rlk/Itk-binding protein, have nonredundant functions in lymphocytes. J Immunol. 2007;179:1768-75 pubmed
Perchonock C, Fernando M, Quinn W, Nguyen C, Sun J, Shapiro M, et al. Negative regulation of interleukin-2 and p38 mitogen-activated protein kinase during T-cell activation by the adaptor ALX. Mol Cell Biol. 2006;26:6005-15 pubmed
Zhang N, He Y. An essential role for c-FLIP in the efficient development of mature T lymphocytes. J Exp Med. 2005;202:395-404 pubmed
Zhang N, He Y. The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes. J Immunol. 2005;174:6967-73 pubmed
产品信息
抗原 :
CD28
Apps. Abbrev. :
Flow Cytometry, IP, IHC-F, Costim, Block
目录 :
102101
克隆 :
37.51
产品 :
纯化抗小鼠CD28
抗体亚型 :
Syrian Hamster IgG
其他名称 :
Tp44, T44
规格 :
50微克
价格(美元) :
45美元
反应物种 :
小鼠
克隆性 :
单克隆
宿主 :
Syrian Hamster
共轭标签/标签/标记 :
PURE
免疫原 :
C57BL/6小鼠t细胞淋巴瘤EL-4
应用注释 :
Additional reported applications (for the relevant formats) include: immunoprecipitation 1 , in vitro costimulation of T and NK cells 1 , in vitro blocking of allogeneic mixed leukocyte response and inhibition of MHC-unrestricted CTL cytotoxicity 3,4 , in vitro induction of thymocyte differentiation 2,5-9,11 , and immunohistochemical staining of acetone-fixed frozen sections. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Endotoxin 0.01 EU/µg, Azide-Free, 0.2 µm filtered) (Cat. No. 102116).
更多信息或购买 :
公司信息
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
1-858-455-9588
公司总部: 美国
Biolegend公司为生物医学研究提供顶级的抗体及试剂产品,旨在加速生命科学领域的研发工作。