产品简要
公司名称 :
BioLegend
其他品牌 :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
产品类型 :
抗体
产品名称 :
Alexa Fluor系列荧光染料®488抗人类FOXP3
目录 :
320212
规格 :
100试验
价格 :
370美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
AF488
克隆名称 :
259D
反应物种 :
人类, 小鼠
应用 :
流式细胞仪
更多信息或购买 :
文章摘录数: 39
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 s8c
Wen Z, Jin K, Shen Y, Yang Z, Li Y, Wu B, et al. N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation. Nat Immunol. 2019;20:313-325 pubmed 出版商
  • 流式细胞仪; 人类; 图 5a
Richardson J, Armbruster N, Günter M, Henes J, Autenrieth S. Staphylococcus aureus PSM Peptides Modulate Human Monocyte-Derived Dendritic Cells to Prime Regulatory T Cells. Front Immunol. 2018;9:2603 pubmed 出版商
  • 流式细胞仪; 人类; 1:10; 图 2a
Wagner D, Amini L, Wendering D, Burkhardt L, Akyüz L, Reinke P, et al. High prevalence of Streptococcus pyogenes Cas9-reactive T cells within the adult human population. Nat Med. 2019;25:242-248 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 8
Valle A, Barbagiovanni G, Jofra T, Stabilini A, Pérol L, Baeyens A, et al. Heterogeneous CD3 expression levels in differing T cell subsets correlate with the in vivo anti-CD3-mediated T cell modulation. J Immunol. 2015;194:2117-27 pubmed 出版商
Farhat A, Weiner A, Posner C, Kim Z, Orcutt Jahns B, Carlson S, et al. Modeling cell-specific dynamics and regulation of the common gamma chain cytokines. Cell Rep. 2021;35:109044 pubmed 出版商
Sivanandham R, Kleinman A, Sette P, Brocca Cofano E, Kilapandal Venkatraman S, Policicchio B, et al. Nonhuman Primate Testing of the Impact of Different Regulatory T Cell Depletion Strategies on Reactivation and Clearance of Latent Simian Immunodeficiency Virus. J Virol. 2020;94: pubmed 出版商
Woolsey C, Jankeel A, Matassov D, Geisbert J, Agans K, Borisevich V, et al. Immune correlates of postexposure vaccine protection against Marburg virus. Sci Rep. 2020;10:3071 pubmed 出版商
Burbano Y, Paz A, Caldon C, Constain J, Gonzáles G, Hernández J, et al. Low Frequency Of Regulatory B-Cells And Increased CD4+ and CD8+ Interferon-γ-producing cells in patients with tropical spastic paraparesis associated with human T-cell lymphotropic virus type. Rev Soc Bras Med Trop. 2019;52:e20190101 pubmed 出版商
Hu M, Eviston D, Hsu P, Marino E, Chidgey A, Santner Nanan B, et al. Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia. Nat Commun. 2019;10:3031 pubmed 出版商
Huijts C, Lougheed S, Bodalal Z, van Herpen C, Hamberg P, Tascilar M, et al. The effect of everolimus and low-dose cyclophosphamide on immune cell subsets in patients with metastatic renal cell carcinoma: results from a phase I clinical trial. Cancer Immunol Immunother. 2019;68:503-515 pubmed 出版商
Kim C, Lee C, Jung J, Ghosh A, Hasan S, Hwang S, et al. The Transcription Factor Ets1 Suppresses T Follicular Helper Type 2 Cell Differentiation to Halt the Onset of Systemic Lupus Erythematosus. Immunity. 2018;49:1034-1048.e8 pubmed 出版商
Bamidele A, Svingen P, Sagstetter M, Sarmento O, González M, Braga Neto M, et al. Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation. Cell Mol Gastroenterol Hepatol. 2019;7:55-71 pubmed 出版商
Detry O, Vandermeulen M, Delbouille M, Somja J, Blétard N, Briquet A, et al. Infusion of mesenchymal stromal cells after deceased liver transplantation: A phase I-II, open-label, clinical study. J Hepatol. 2017;67:47-55 pubmed 出版商
Huijts C, Santegoets S, Quiles Del Rey M, de Haas R, Verheul H, de Gruijl T, et al. Differential effects of inhibitors of the PI3K/mTOR pathway on the expansion and functionality of regulatory T cells. Clin Immunol. 2016;168:47-54 pubmed 出版商
Boularan C, Hwang I, Kamenyeva O, Park C, Harrison K, Huang Z, et al. B Lymphocyte-Specific Loss of Ric-8A Results in a Gα Protein Deficit and Severe Humoral Immunodeficiency. J Immunol. 2015;195:2090-102 pubmed 出版商
He T, Brocca Cofano E, Gillespie D, Xu C, Stock J, Ma D, et al. Critical Role for the Adenosine Pathway in Controlling Simian Immunodeficiency Virus-Related Immune Activation and Inflammation in Gut Mucosal Tissues. J Virol. 2015;89:9616-30 pubmed 出版商
Dupont G, Demaret J, Venet F, Malergue F, Malcus C, Poitevin Later F, et al. Comparative dose-responses of recombinant human IL-2 and IL-7 on STAT5 phosphorylation in CD4+FOXP3- cells versus regulatory T cells: a whole blood perspective. Cytokine. 2014;69:146-9 pubmed 出版商
Vudattu N, Waldron Lynch F, Truman L, Deng S, Preston Hurlburt P, Torres R, et al. Humanized mice as a model for aberrant responses in human T cell immunotherapy. J Immunol. 2014;193:587-96 pubmed 出版商
Ferraro A, D Alise A, Raj T, Asinovski N, Phillips R, Ergun A, et al. Interindividual variation in human T regulatory cells. Proc Natl Acad Sci U S A. 2014;111:E1111-20 pubmed 出版商
Sutavani R, Bradley R, Ramage J, Jackson A, Durrant L, Spendlove I. CD55 costimulation induces differentiation of a discrete T regulatory type 1 cell population with a stable phenotype. J Immunol. 2013;191:5895-903 pubmed 出版商
Giovannetti A, Maselli A, Colasanti T, Rosato E, Salsano F, Pisarri S, et al. Autoantibodies to estrogen receptor ? in systemic sclerosis (SSc) as pathogenetic determinants and markers of progression. PLoS ONE. 2013;8:e74332 pubmed 出版商
Faustman D, Wang L, Okubo Y, Burger D, Ban L, Man G, et al. Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes. PLoS ONE. 2012;7:e41756 pubmed 出版商
Rech A, Mick R, Martin S, Recio A, Aqui N, Powell D, et al. CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients. Sci Transl Med. 2012;4:134ra62 pubmed 出版商
Tresoldi E, Dell albani I, Stabilini A, Jofra T, Valle A, Gagliani N, et al. Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells. Haematologica. 2011;96:1357-65 pubmed 出版商
Rapoport A, Aqui N, Stadtmauer E, Vogl D, Fang H, Cai L, et al. Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma. Blood. 2011;117:788-97 pubmed 出版商
Geller M, Cooley S, Judson P, Ghebre R, Carson L, Argenta P, et al. A phase II study of allogeneic natural killer cell therapy to treat patients with recurrent ovarian and breast cancer. Cytotherapy. 2011;13:98-107 pubmed 出版商
Vonderheide R, LoRusso P, Khalil M, Gartner E, Khaira D, Soulieres D, et al. Tremelimumab in combination with exemestane in patients with advanced breast cancer and treatment-associated modulation of inducible costimulator expression on patient T cells. Clin Cancer Res. 2010;16:3485-94 pubmed 出版商
Cassani B, Poliani P, Moratto D, Sobacchi C, Marrella V, Imperatori L, et al. Defect of regulatory T cells in patients with Omenn syndrome. J Allergy Clin Immunol. 2010;125:209-16 pubmed 出版商
Long S, Cerosaletti K, Bollyky P, Tatum M, Shilling H, Zhang S, et al. Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects. Diabetes. 2010;59:407-15 pubmed 出版商
Torgerson T, Genin A, Chen C, Zhang M, Zhou B, Anover Sombke S, et al. FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression. J Immunol. 2009;183:907-15 pubmed 出版商
Long S, Walker M, Rieck M, James E, Kwok W, Sanda S, et al. Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects. Eur J Immunol. 2009;39:612-20 pubmed 出版商
Gong G, Shao L, Wang Y, Chen C, Huang D, Yao S, et al. Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4+CD25+Foxp3+ T regulatory cells in mycobacterial infection. Blood. 2009;113:837-45 pubmed 出版商
Monti P, Scirpoli M, Maffi P, Piemonti L, Secchi A, Bonifacio E, et al. Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells. Diabetes. 2008;57:2341-7 pubmed 出版商
Fox B, Bignone P, Brown P, Banham A. Defense of the clone: antibody 259D effectively labels human FOXP3 in a variety of applications. Blood. 2008;111:3897-9 pubmed 出版商
Long S, Buckner J. Combination of rapamycin and IL-2 increases de novo induction of human CD4(+)CD25(+)FOXP3(+) T cells. J Autoimmun. 2008;30:293-302 pubmed 出版商
Tran D, Ramsey H, Shevach E. Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. Blood. 2007;110:2983-90 pubmed
Groh V, Smythe K, Dai Z, Spies T. Fas-ligand-mediated paracrine T cell regulation by the receptor NKG2D in tumor immunity. Nat Immunol. 2006;7:755-62 pubmed
Gavin M, Torgerson T, Houston E, deRoos P, Ho W, Stray Pedersen A, et al. Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc Natl Acad Sci U S A. 2006;103:6659-64 pubmed
Yang Z, Novak A, Stenson M, Witzig T, Ansell S. Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma. Blood. 2006;107:3639-46 pubmed
产品信息
抗原 :
FOXP3
Apps. Abbrev. :
流式细胞仪细胞内染色
目录 :
320212
克隆 :
259D
产品 :
Alexa Fluor系列荧光染料®488抗人类FOXP3
抗体亚型 :
Mouse IgG1, κ
其他名称 :
Forkhead box protein P3, Scurfin, JM2, IPEX, Zinc finger protein JM2
规格 :
100试验
价格(美元) :
370美元
反应物种 :
人类
克隆性 :
单克隆
宿主 :
小鼠
共轭标签/标签/标记 :
A488
免疫原 :
全长FOXP3蛋白
应用注释 :
Additional reported applications (for the relevant formats) include: Western blotting 1 , and immunohistochemical staining 1 of acetone-fixed frozen sections and formalin-fixed paraffin-embedded sections. The 259D antibody gives strong positivity on paraffin and frozen sections and the antibody stains some epithelial cells. The binding of 206D to FOXP3 can be partially blocked by 259D, but 206D does not show significant blocking effect on 259D binding. NOTE : For flow cytometric staining with this clone, True-Nuclear Transcription Factor Buffer Set (Cat. No. 424401 ) offers improved staining and is highly recommended.
更多信息或购买 :
公司信息
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
1-858-455-9588
公司总部: 美国
Biolegend公司为生物医学研究提供顶级的抗体及试剂产品,旨在加速生命科学领域的研发工作。