产品简要
公司名称 :
BioLegend
其他品牌 :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
产品类型 :
抗体
产品名称 :
Ultra-LEAF™ Purified anti-mouse IL-4
目录 :
504121
规格 :
100微克
价格 :
118美元
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
11B11
反应物种 :
人类, 小鼠
应用 :
酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 中和反应, 免疫沉淀, 流式细胞仪, 抑制或激活实验
更多信息或购买 :
文章摘录数: 57
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 图 4d
Lin X, Twelkmeyer T, Zhu D, Zhang L, Zhao Y, Zhang C, et al. Homeostatic regulation of T follicular helper and antibody response to particle antigens by IL-1Ra of medullary sinus macrophage origin. Proc Natl Acad Sci U S A. 2021;118: pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1a
Hang S, Paik D, Yao L, Kim E, Jamma T, Lu J, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019;576:143-148 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 6c
Qian L, Bajana S, Georgescu C, Peng V, Wang H, Adrianto I, et al. Suppression of ILC2 differentiation from committed T cell precursors by E protein transcription factors. J Exp Med. 2019;216:884-899 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1f
Burton O, Tamayo J, Stranks A, Koleoglou K, Oettgen H. Allergen-specific IgG antibody signaling through FcγRIIb promotes food tolerance. J Allergy Clin Immunol. 2018;141:189-201.e3 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3e
Fu G, Xu Q, Qiu Y, Jin X, Xu T, Dong S, et al. Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. J Exp Med. 2017;214:1453-1469 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s2a
Beyaz S, Kim J, Pinello L, Xifaras M, Hu Y, Huang J, et al. The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells. Nat Immunol. 2017;18:184-195 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 7a
Janssen E, Tohme M, Hedayat M, Leick M, Kumari S, Ramesh N, et al. A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. J Clin Invest. 2016;126:3837-3851 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5a
Contreras F, Prado C, Gonzalez H, Franz D, Osorio Barrios F, Osorio F, et al. Dopamine Receptor D3 Signaling on CD4+ T Cells Favors Th1- and Th17-Mediated Immunity. J Immunol. 2016;196:4143-9 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Apostolidis S, Rodríguez Rodríguez N, Suárez Fueyo A, Dioufa N, Ozcan E, Crispín J, et al. Phosphatase PP2A is requisite for the function of regulatory T cells. Nat Immunol. 2016;17:556-64 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1c
Smith R, Reyes N, Khandelwal P, Schlereth S, Lee H, Masli S, et al. Secondary allergic T cell responses are regulated by dendritic cell-derived thrombospondin-1 in the setting of allergic eye disease. J Leukoc Biol. 2016;100:371-80 pubmed 出版商
  • 免疫沉淀; 小鼠
Richardson E, Shukla S, Sweet D, Wearsch P, Tsichlis P, Boom W, et al. Toll-like receptor 2-dependent extracellular signal-regulated kinase signaling in Mycobacterium tuberculosis-infected macrophages drives anti-inflammatory responses and inhibits Th1 polarization of responding T cells. Infect Immun. 2015;83:2242-54 pubmed 出版商
  • 流式细胞仪; 小鼠
Sakala I, Chaudhri G, Eldi P, Buller R, Karupiah G. Deficiency in Th2 cytokine responses exacerbate orthopoxvirus infection. PLoS ONE. 2015;10:e0118685 pubmed 出版商
  • 免疫细胞化学; 人类
Koga T, Hedrich C, Mizui M, Yoshida N, Otomo K, Lieberman L, et al. CaMK4-dependent activation of AKT/mTOR and CREM-? underlies autoimmunity-associated Th17 imbalance. J Clin Invest. 2014;124:2234-45 pubmed 出版商
Andreas N, Müller S, Templin N, Jordan P, Schuhwerk H, Muller M, et al. Incidence and severity of G6PI-induced arthritis are not increased in genetically distinct mouse strains upon aging. Arthritis Res Ther. 2021;23:222 pubmed 出版商
Montes De Oca M, de Labastida Rivera F, Winterford C, Frame T, Ng S, Amante F, et al. IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection. PLoS Pathog. 2020;16:e1008994 pubmed 出版商
Xia X, Cao G, Sun G, Zhu L, Tian Y, Song Y, et al. GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis. J Clin Invest. 2020;130:5180-5196 pubmed 出版商
Imanishi T, Unno M, Kobayashi W, Yoneda N, Akira S, Saito T. mTORC1 Signaling Controls TLR2-Mediated T-Cell Activation by Inducing TIRAP Expression. Cell Rep. 2020;32:107911 pubmed 出版商
Price C, Jones S, Mihelcic M, Santic M, Abu Kwaik Y. Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector. Cell Host Microbe. 2020;27:571-584.e7 pubmed 出版商
Williams G, Marmion D, Schonhoff A, Jurkuvenaite A, Won W, Standaert D, et al. T cell infiltration in both human multiple system atrophy and a novel mouse model of the disease. Acta Neuropathol. 2020;139:855-874 pubmed 出版商
Wang L, Shen E, Luo L, Rabe H, Wang Q, Yin J, et al. Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor. Cell Rep. 2019;29:1848-1861.e6 pubmed 出版商
Clancy Thompson E, Chen G, LaMarche N, Ali L, Jeong H, Crowley S, et al. Transnuclear mice reveal Peyer's patch iNKT cells that regulate B-cell class switching to IgG1. EMBO J. 2019;38:e101260 pubmed 出版商
Amir M, Chaudhari S, Wang R, Campbell S, Mosure S, Chopp L, et al. REV-ERBα Regulates TH17 Cell Development and Autoimmunity. Cell Rep. 2018;25:3733-3749.e8 pubmed 出版商
He Z, Zhang J, Huang Z, Du Q, Li N, Zhang Q, et al. Sumoylation of RORγt regulates TH17 differentiation and thymocyte development. Nat Commun. 2018;9:4870 pubmed 出版商
Wu B, Zhang S, Guo Z, Wang G, Zhang G, Xie L, et al. RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T-Helper-2-Cell-Biased Programs. Immunity. 2018;49:886-898.e5 pubmed 出版商
Rolot M, Dougall A, Chetty A, Javaux J, Chen T, Xiao X, et al. Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection. Nat Commun. 2018;9:4516 pubmed 出版商
Singh A, Khare P, Obaid A, Conlon K, Basrur V, Depinho R, et al. SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2. Nat Commun. 2018;9:4515 pubmed 出版商
Shimada K, Porritt R, Markman J, O Rourke J, Wakita D, Noval Rivas M, et al. T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation. Immunity. 2018;49:873-885.e7 pubmed 出版商
Obata Ninomiya K, Ishiwata K, Nakano H, Endo Y, Ichikawa T, Onodera A, et al. CXCR6+ST2+ memory T helper 2 cells induced the expression of major basic protein in eosinophils to reduce the fecundity of helminth. Proc Natl Acad Sci U S A. 2018;115:E9849-E9858 pubmed 出版商
Fang D, Cui K, Mao K, Hu G, Li R, Zheng M, et al. Transient T-bet expression functionally specifies a distinct T follicular helper subset. J Exp Med. 2018;215:2705-2714 pubmed 出版商
Deason K, Troutman T, Jain A, Challa D, Mandraju R, Brewer T, et al. BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation. J Exp Med. 2018;215:2413-2428 pubmed 出版商
Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt F, Liniany L, Knight D, et al. PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells. Immunity. 2018;49:247-263.e7 pubmed 出版商
Miller M, Shehat M, Alcedo K, Spinel L, SOULAKOVA J, Tigno Aranjuez J. Frontline Science: RIP2 promotes house dust mite-induced allergic airway inflammation. J Leukoc Biol. 2018;104:447-459 pubmed 出版商
Rogers M, Lamens K, Shafagati N, Johnson M, Oury T, Joyce S, et al. CD4+ Regulatory T Cells Exert Differential Functions during Early and Late Stages of the Immune Response to Respiratory Viruses. J Immunol. 2018;201:1253-1266 pubmed 出版商
Arnold I, Artola Borán M, Tallón de Lara P, Kyburz A, Taube C, OTTEMANN K, et al. Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation. J Exp Med. 2018;215:2055-2072 pubmed 出版商
Langenhorst D, Haack S, Göb S, Uri A, Luhder F, Vanhove B, et al. CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo. Front Immunol. 2018;9:1060 pubmed 出版商
Sen S, He Z, Ghosh S, DERY K, Yang L, Zhang J, et al. PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5. J Immunol. 2018;201:440-450 pubmed 出版商
Tanaka S, Pfleger C, Lai J, Roan F, Sun S, Ziegler S. KAP1 Regulates Regulatory T Cell Function and Proliferation in Both Foxp3-Dependent and -Independent Manners. Cell Rep. 2018;23:796-807 pubmed 出版商
Zhang J, He Z, Sen S, Wang F, Zhang Q, Sun Z. TCF-1 Inhibits IL-17 Gene Expression To Restrain Th17 Immunity in a Stage-Specific Manner. J Immunol. 2018;200:3397-3406 pubmed 出版商
Kling J, Jordan M, Pitt L, Meiners J, Thanh Tran T, Tran L, et al. Temporal Regulation of Natural Killer T Cell Interferon Gamma Responses by β-Catenin-Dependent and -Independent Wnt Signaling. Front Immunol. 2018;9:483 pubmed 出版商
May S, Owen H, Phesse T, Greenow K, Jones G, Blackwood A, et al. Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation. J Pathol. 2018;245:270-282 pubmed 出版商
Chyuan I, Tsai H, Wu C, Sung C, Hsu P. TRAIL-Mediated Suppression of T Cell Receptor Signaling Inhibits T Cell Activation and Inflammation in Experimental Autoimmune Encephalomyelitis. Front Immunol. 2018;9:15 pubmed 出版商
Xiao X, Fan Y, Li J, Zhang X, Lou X, Dou Y, et al. Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation. J Exp Med. 2018;215:559-574 pubmed 出版商
Maseda D, Johnson E, Nyhoff L, Baron B, Kojima F, Wilhelm A, et al. mPGES1-Dependent Prostaglandin E2 (PGE2) Controls Antigen-Specific Th17 and Th1 Responses by Regulating T Autocrine and Paracrine PGE2 Production. J Immunol. 2018;200:725-736 pubmed 出版商
Shi B, Geng J, Wang Y, Wei H, Walters B, Li W, et al. Foxp1 Negatively Regulates T Follicular Helper Cell Differentiation and Germinal Center Responses by Controlling Cell Migration and CTLA-4. J Immunol. 2018;200:586-594 pubmed 出版商
Ibrahim M, Scozzi D, Toth K, Ponti D, Kreisel D, Menna C, et al. Naive CD4+ T Cells Carrying a TLR2 Agonist Overcome TGF-β-Mediated Tumor Immune Evasion. J Immunol. 2018;200:847-856 pubmed 出版商
Li B, Wang X, Choi I, Wang Y, Liu S, Pham A, et al. miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity. J Clin Invest. 2017;127:3702-3716 pubmed 出版商
Read K, Powell M, Baker C, Sreekumar B, Ringel Scaia V, Bachus H, et al. Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4+ Th Cells. J Immunol. 2017;199:2377-2387 pubmed 出版商
Clancy Thompson E, Chen G, Tyler P, Servos M, Barisa M, Brennan P, et al. Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets. J Immunol. 2017;199:159-171 pubmed 出版商
Suzuki T, Murakami S, Biswal S, Sakaguchi S, Harigae H, Yamamoto M, et al. Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice. Mol Cell Biol. 2017;37: pubmed 出版商
Tian L, Goldstein A, Wang H, Ching Lo H, Sun Kim I, Welte T, et al. Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming. Nature. 2017;544:250-254 pubmed 出版商
Jiang J, Liu C, Liu M, Shen Y, Hu X, Wang Q, et al. OX40 signaling is involved in the autoactivation of CD4+CD28- T cells and contributes to the pathogenesis of autoimmune arthritis. Arthritis Res Ther. 2017;19:67 pubmed 出版商
Ulrich B, Verdan F, McKenzie A, Kaplan M, Olson M. STAT3 Activation Impairs the Stability of Th9 Cells. J Immunol. 2017;198:2302-2309 pubmed 出版商
Levine A, Hemmers S, Baptista A, Schizas M, Faire M, Moltedo B, et al. Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity. J Exp Med. 2017;214:609-622 pubmed 出版商
Reynolds L, Harcus Y, Smith K, Webb L, Hewitson J, Ross E, et al. MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus. J Immunol. 2014;193:2984-93 pubmed 出版商
Charles N, Hardwick D, Daugas E, Illei G, Rivera J. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med. 2010;16:701-7 pubmed 出版商
Ohnmacht C, Voehringer D. Basophil effector function and homeostasis during helminth infection. Blood. 2009;113:2816-25 pubmed 出版商
Xu G, Liu D, Fan Y, Yang X, Korner H, Fu Y, et al. Lymphotoxin alpha beta 2 (membrane lymphotoxin) is critically important for resistance to Leishmania major infection in mice. J Immunol. 2007;179:5358-66 pubmed
产品信息
抗原 :
IL-4
Apps. Abbrev. :
ELISA Capture, CyTOF®, ELISPOT Capture, Neut, ICC, IP, IHC
目录 :
504121
克隆 :
11B11
产品 :
Ultra-LEAF™ Purified anti-mouse IL-4
抗体亚型 :
Rat IgG1, κ
其他名称 :
Interleukin-4, Ia inducing factor (IaIF), B cell stimulating factor-1 (BSF-1), Hodgkin's cell growth factor (HCGF), Mast cell growth factor-2 (MCGF-2), Macrophage fusion factor (MFF), T cell growth factor-2 (TCGF-2)
规格 :
100微克
价格(美元) :
118美元
反应物种 :
小鼠
克隆性 :
单克隆
宿主 :
大鼠
共轭标签/标签/标记 :
ULEAF
免疫原 :
Partially purified native mouse IL-4
应用注释 :
ELISA 1,2,10,13 or ELISPOT 5 Capture: The purified 11B11 antibody is useful as the capture antibody in a sandwich ELISA or ELISPOT assay, when used in conjunction with the biotinylated BVD6-24G2 antibody (Cat. No. 504202) as the detecting antibody and recombinant mouse IL-4 (Cat. No. 575609) as the standard. The LEAF™ purified antibody is suggested for ELISPOT capture. Neutralization 1-2,9,12 : The 11B11 antibody can neutralize the bioactivity of natural or recombinant IL-4. The LEAF™ purified antibody (Endotoxin 0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for neutralization of mouse IL-4 bioactivity in vivo and in vitro (Cat. No. 504108). Additional reported applications (for the relevant formats) include: immunoprecipitation 16 , immunohistochemical staining of formalin-fixed paraffin-embedded tissue sections 8 and paraformaldehyde-fixed, saponin-treated frozen tissue sections 6,7 , and immunocytochemistry 4 . Note: For testing mouse IL-4 in serum, plasma or supernatant, BioLegend s ELISA Max™ Sets (Cat. No. 431101 to 431106) are specially developed and recommended.
更多信息或购买 :
公司信息
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
1-858-455-9588
公司总部: 美国
Biolegend公司为生物医学研究提供顶级的抗体及试剂产品,旨在加速生命科学领域的研发工作。